Anti-inflammatory activity of naturally occuring diarylheptanoids – A review

Abstract

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, if it becomes uncontrolled, inflammation may result in autoimmune or auto inflammatory disorders, neurodegenerative diseases or cancers. The currently available anti-inflammatory drug therapy is often not successful or induces severe side effects. Thus, the search of new therapeutic options for the treatment of inflammation is highly required. Medicinal plants have been an interesting source for obtaining new active compounds. Diarylheptanoids characterized by a 1, 7-diphenylheptane structural skeleton, are a class of secondary plant metabolites that have gained increasing interest over the last few decades due to a wide variety of biological activities. This review covers 182 natural linear or macrocyclic diarylheptanoids described in the period of 1982 to 2020 with anti-inflammatory activities evaluated using quantified in vitro and/or in vivo assays. All of these data highlight the pharmacological potential of these natural compounds to act as anti-inflammatory drugs.

Metabolomics and Transcriptomics Reveal that Diarylheptanoids Vary in Amomum tsao-ko Fruit Development

“…Diarylheptanoids are characteristic nonvolatile metabolite constituents in Amomum . Previous studies have isolated and identified about 90 diarylheptanoids, , which are mainly divided into linear- and epoxy diarylheptanoids. In our investigation, 82 diarylheptanoids (Supporting Table 1) were detected and tentatively identified based on the fragment ions and molecular ions from high-resolution mass spectra and databases.…”

“…Since 1815, Vogel first reported the major pigment in turmeric (Curcuma longa). About 500 such compounds have been isolated and determined, mainly distributed in Zingiberaceae, Betulaceae, Myricaceae, Aceraceae, Burseraceae, and Juglandaceae plants. , Diarylheptanoids have attracted considerable attention due to their various biological functions and pharmacological activities . For instance, curcumin can be used as anticancer and antimutagenic agents and has been classified as a third-generation cancer chemopreventive drug by the National Cancer Institute. , …”

“…Since 1815, Vogel first reported the major pigment in turmeric (Curcuma longa). About 500 such compounds have been isolated and determined, 18 mainly distributed in Zingiberaceae, Betulaceae, Myricaceae, Aceraceae, Burseraceae, and Juglandaceae plants. 18,19 Diarylheptanoids have attracted considerable attention due to their various biological functions and pharmacological activities.…”

Screening of Antioxidant, Antibacterial, Anti-Adipogenic, and Anti-Inflammatory Activities of Five Selected Medicinal Plants of Nepal

“…Recent studies have shown that this plant contains diarylheptanoids with anti-inflammatory and antifilarial activity. 48 , 49 These diarylheptanoids, especially platyphylloside, inhibited the production of pro-inflammatory cytokines (mainly TNF-α and IL-6). Similar affirmative activity of this compound was observed in an in-vivo model of mice.…”

An integrated approach of homogenization‐ultrasound‐assisted extraction followed by high‐speed countercurrent chromatography for rapidly preparative separation naphthoquinones and diarylheptanes from Juglands mandshurica Maxim. exocarp

“…F I G U R E 1 High-performance liquid chromatography (HPLC) chromatograms (280 nm) of standards mixture (A) and sample extract (B). Regiolone (1), juglone (2), myricatomento-genin (3), galleon (4), 2-oxatrycyclo [13.2.2.13,7]eicosa-3,5,7 (20),15,17,18-hexaen-10-16-diol (5), and juglanin A (6). roots, and bark can all be utilized in that capacity [4].…”