Diarrhea caused by Shigella flexneri in patients with primary HIV infection

Abstract

Acute bacterial diarrhea due to Shigella spp. infection is a common disease in low-income settings. In developed countries, these are usually cases of patients with recent travel history to tropical countries. In recent years, there has been a noticeable increase of cases of Shigella infection amongst men having sex with men in developed countries with no recent travel history. We present a report of two cases of patients hospitalized due to diarrhea of Shigella flexneri origin. During hospitalization, both of them were diagnosed also with primary HIV infection and one patient also had acute hepatitis A. The course of the disease was complicated in both cases and symptoms were severe. In both cases, Shigella was most likely transmitted through sexual contact. Shigella infection should also be considered as one of the sexually transmitted infections.

Repurposing of Synthetic Acetaminophen Derivatives Containing Benzothiazole Scaffold as Alternative Therapy for Infectious Diarrhea Caused by Drug-Resistant Shigella Species

“…The solid precipitate was collected on a filter and crystallized from methanol to give the title compound. (9), 1453 (9), 1428 (17), 1404 (17), 1379 (15), 1353 (18), 1323 (16), 1293 (11), 1238 (17), 955 (32) (11), 429 (11), 409 (42), 385 (10), 316 (100), 300 (22), 281 (19), 216 (70), 202 (14), 192 (21), 150 (70); Anal. Calcd.…”

“…Most of the breakouts of shigellosis have been ascribed to S. flexneri [10]. Clinical cases of diarrhea caused by Shigella flexneri have also been reported among patients with primary HIV infection [11,12]. Shigella species are primarily spread through the faeco-oral route, whereas the housefly Musca domestica act as a vector for their transmission [13].…”

Repurposing Synthetic Acetaminophen Derivatives Containing a Benzothiazole Scaffold as an Alternative Therapy for Infectious Diarrhea Caused by Drug-Resistant Shigella Species

“…N-(2-(6-ethoxy-5- ); 161.7 (C-5 iv ); 161.4 (C-5 v ); 158.5 (C-5 vi ); 157.2 (C-3a v ); 156.9 (C-3a vi ); 152.0 (C-3a and C-3a ′′ ); 151.0 (C-3a ′′′ ); 150.1 (C-3a iv ); 143.6 (C-2 ′ ); 141.8 (C-3 ′ ); 141.5 (C-4 ′ ); 141.1 (C-6 v ); 140.9 (C-6 vi ); 137.4 (C-4a); 137.3 (C-4a ′′ ); 136.9 (C-5 ′ ); 133.1 (C-1 ′ ); 130.4 (C-4a ′′′ and C-6 ′ ); 128.7 (C-4a iv ); 128.0 (C-4a v ); 127.8 (C-4a vi ); 123.9 (C-7); 123.8 (C-7 ′′ ); 123.5 (C-6 iv ); 122.1 (C-6); 121.7 (C-6 ′′ ); 121.4 (C-6 ′′′ ); 120.9 (C-7 ′′′ ); 120.7 (C-7 iv ); 117. (9), 1453 (9), 1428 (17), 1404 (17), 1379 (15), 1353 (18), 1323 (16), 1293 (11), 1238 (17), 955 (32) (11), 429 (11), 409 (42), 385 (10), 316 (100), 300 (22), 281 (19), 216 (70), 202 (14), 192 (21), 150 (70); Anal. Calcd.…”

“…Most of the breakouts of shigellosis have been ascribed to S. flexneri [10]. Clinical cases of diarrhea caused by Shigella flexneri have also been reported among patients with primary HIV infection [11,12]. Shigella species are primarily spread through the fecaloral route, whereas the housefly Musca domestica acts as a vector for their transmission [13].…”

Euphorbia hirta Linn (Euphorbiaceae), une espèce végétale prometteuse pour combattre les dysenteries bacillaires: Expérimentations in vitro en Côte d’Ivoire

“…Les espèces bactériennes responsables des gastro-entérites dont celles du genre Shigella nécessitent généralement un traitement antibiotique. La plupart des pays où la shigellose est endémique et/ou épidémique sont également et fortement touchés par le VIH/sida (Katarzyna et al, 2019). Les traitements classiques jusqu'alors recommandés sont soit une aminopénicilline soit le cotrimoxazole.…”