Diaporone A, a new antibacterial secondary metabolite from the plant endophytic fungus Diaporthe sp.

Guo, Longfang; Niu, Shubin; Chen, Shuanglin; Liu, Ling

doi:10.1038/s41429-019-0251-3

Cited by 27 publications

(17 citation statements)

References 15 publications

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“…Guo et al isolated a new antibacterial secondary metabolite (Diaporone A) from the plant endophytic fungus Diaporthe sp. [ 29 ]. Seven previously unreported cyclonerane derivatives were isolated from the culture of Trichoderma asperellum A-YMD-9-2, an endophytic fungus obtained from the marine red alga Gracilaria verrucosa [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Diversity and Antimicrobial Activity of Endophytic Fungi Isolated from Chloranthus japonicus Sieb in Qinling Mountains, China

Shi

et al. 2020

IJMS

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The plant Chloranthus japonicus Sieb is known for its anticancer properties and mainly distributed in China, Japan, and Korea. In this study, we firstly investigated the diversity and antimicrobial activity of the culturable endophytic fungi from C. japonicus. A total of 332 fungal colonies were successfully isolated from 555 tissue segments of the medicinal plant C. japonicus collected from Qinling Mountains, China. One hundred and thirty representative morphotype strains were identified according to ITS rDNA sequence analyses and were grouped into three phyla (Ascomycota, Basidiomycota, Mucoromycota), five classes (Dothideomycetes, Sordariomycetes, Eurotiomycetes, Agaricomycetes, Mucoromycetes), and at least 30 genera. Colletotrichum (RA, 60.54%) was the most abundant genus, followed by Aspergillus (RA, 11.75%) and Diaporthe (RA, 9.34%). The Species Richness Index (S, 56) and the Shannon-Wiener Index (H′, 2.7076) indicated that C. japonicus harbored abundant fungal resources. Thirteen out of 130 endophytic fungal ethyl acetate extracts exhibited inhibitory activities against at least one pathogenic bacterium or fungus. Among of these, F8158, which was identified as Trichoderma cf. harzianum, exhibited good antagonistic capacities (the percent inhibition of mycelial growth ranged from 47.72~88.18) for different pathogens and has a potential application in biological control. In addition, it is noteworthy that the strain F8157 (Thanatephorus cucumeris, an opportunistic pathogen) showed antibacterial and antifungal activity, which is reported firstly in this study, and should be investigated further. Taken together, these results indicated that the endophytic fungi from C. japonicus may be of potential interest in screening bio-control agents and discovering of new bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Diversity and Antimicrobial Activity of Endophytic Fungi Isolated from Chloranthus japonicus Sieb in Qinling Mountains, China

Shi

et al. 2020

IJMS

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“…A new dihydroisocoumarin, diaporone A 241 ( Figure 8 ), was isolated from the ethyl acetate extract of the cultures of the endophytic fungus Diaporthe sp. [ 78 ].…”

Section: New Metabolites Isolated From Plant Endophytesmentioning

confidence: 99%

“…Compound 241 was tested for antibacterial activity against Bacillus subtilis (ATCC 6633), Staphylococcus aureus (CGMCC 1.2465), Streptococcus pneumoniae (CGMCC 1.1692), Escherichia coli (CGMCC 1.2340), the results showed that 241 displayed modest antibacterial activity against B. subtilis with MIC value of 66.7 µM (the positive control gentamycin showed MIC value of 1.3 µM) [ 78 ].…”

Section: Biological Activitymentioning

confidence: 99%

“…Compound 241 was also tested for cytotoxicity against SH-SY5Y (human glioma cell lines), HeLa (cervical epithelial cells), HCT116 (human colon cancer cells), HepG2 (human hepatocellular carcinoma cells), A549 (human lung cancer cells), and MCF7 (human breast cancer cells). Compound 241 showed weak cytotoxic effects against HeLa cells with IC 50 value of 97.4 μM, while the positive control cisplatin showed IC 50 value of 21.1 µM [ 78 ].…”

Section: Biological Activitymentioning

confidence: 99%

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Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Zheng

Zhang

et al. 2021

IJMS

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Secondary metabolites isolated from plant endophytic fungi have been getting more and more attention. Some secondary metabolites exhibit high biological activities, hence, they have potential to be used for promising lead compounds in drug discovery. In this review, a total of 134 journal articles (from 2017 to 2019) were reviewed and the chemical structures of 449 new metabolites, including polyketides, terpenoids, steroids and so on, were summarized. Besides, various biological activities and structure-activity relationship of some compounds were aslo described.

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“…Nowadays, there is a growing trend showing that people start to focus on plant endophytes to produce natural products, including polyketides (Shi et al 2020) from Artemisia argyi, dihydroisocoumarin derivative from Diaporthe sp. (Guo et al 2020),hispidulones from Chaetosphaeronema hispidulum(Zhang et al 2020). As plants have been the potential candidates to produce best sources of natural bioactive compounds which can be applied in agriculture, medicine and food industry, so that people have focused on these plant endophytes.…”

Section: Introductionmentioning

confidence: 99%

An Asarone Producing Aspergillus Niger From Asarum Heterotropoides With Whole Genome Sequencing

Duan¹,

Song²,

Zeng³

et al. 2021

Preprint

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Asarone could decrease Aβ, APP, Beclin-1level and clearing Aβ accumulation, which makes it to be one potential therapeutic agent for AD treatment. This study investigated the endophytic fungus got from Asarum heterotropoides Fr.Schmidt var. mandshuricum (Maxim.) kitag. The phylogenetic tree based on single copy orthologues at protein level got from genome sequence analysis showed that the endophytic fungus we got was Aspergillus niger. The total length of nonredundant sequences was nearly 34.7 Mb, comprising approximately 61 contigs sequences. In total, 8,755 genes were predicted to encoding proteins, and 18,611,392 high-quality clean reads were generated using the Illumina NovaSeq platform with paired-end sequencing mode. In this study, the theoretical yield of cis-asarone was higher than the traditional ways extracted from essential oil, which was evaluated according to the reverse-phase high performance liquid chromatography (HPLC). The highest yield appeared from the slant cultivation instead of liquid fermentation, and the mature black spore were the final supporter of cis-asarone. This strain was capable of producing cis-asarone and could be a fascinating reservoir of cis-asarone for further industrial manufacture.

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Diaporone A, a new antibacterial secondary metabolite from the plant endophytic fungus Diaporthe sp.

Cited by 27 publications

References 15 publications

Diversity and Antimicrobial Activity of Endophytic Fungi Isolated from Chloranthus japonicus Sieb in Qinling Mountains, China

Diversity and Antimicrobial Activity of Endophytic Fungi Isolated from Chloranthus japonicus Sieb in Qinling Mountains, China

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

An Asarone Producing Aspergillus Niger From Asarum Heterotropoides With Whole Genome Sequencing

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