Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion

Kusche, Jürgen; Stahlknecht, C. D.; Lorenz, W.; Reichert, G.; Richter, Hans G.

doi:10.1007/bf01964885

Cited by 31 publications

(9 citation statements)

References 13 publications

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“…mained at normal adult levels (32-63 U/mg protein). DAO activity in the proximal and middle third of the small intestine was albout 20 were <2%. DAO from all tissues measured, other than the intestine, showed no increase with age ( Fig.…”

Section: Resultsmentioning

confidence: 91%

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Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.

Luk¹,

Bayless²,

Baylin³

1980

J. Clin. Invest.

231

158

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A B S T R A C T Diamine oxidase (histaminase) is an enzyme founid in high concentrations in the intestinal mucosa of humans and other mammalian species. We investigate(l whether plasma and mucosal levels of diaminie oxidase activity reflect both the maturational status ofthe mucosa during its development in the newborn rat and the degree of mucosal damage during its injury in the adult rat. Litter mates were reared under identical conditions and killed at different ages from day 0 to day 40 after birth. Diamine oxidase in the small intestine was low at birth, increased gradually with age, reached a peak at 22 d, and then remained at normiial adult levels, similar to the developmental patterns of maltase and sucrase. Plasma diamine oxidase rose in parallel with intestinal levels (n = 500, r = 0.84, P < 0.001), reached a peak at 24 d, and then remiained at normal adult levels. Diamine oxidase activitv in 15 nonintestinal tissues was <5% of ileal mucosal activity, and no nonintestinal activities showed increase with age. Adult rat intestinal loops were perfused with hyperosmolar sodium sulfate solutions to procluce selective d(amage to villus mucosa. With increasing mucosal damage, there was a progressive decrease in the enzyme activities studied; first, lactase levels fell, then maltase and sucrase, and finally muciosal and plasma diamine oxidase activity levels fell. The decrease in plasma diamine oxidase reflected the degree of mucosal damage (n = 29, P < 0.04). Diamine oxidase activity is thus unique among intestinal mucosal enzymes studied to date in that circulating levels can serve as a marker of mucosal maturation and integrity.

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Section: Resultsmentioning

confidence: 91%

“…Previous studies have suggested that DAO may play a protective role in intestinal ischemia by metabolizing increased levels of histamine (19,20). In addition to histamiinie, the polyamine precursor putrescine is also a preferred in vitro substrate for DAO.…”

Section: Resultsmentioning

confidence: 99%

Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.

Luk¹,

Bayless²,

Baylin³

1980

J. Clin. Invest.

231

158

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“…histamine concentrations were associated with significantly reduced survival times after intestinal ischaemia and reperfusion [7]. To start a programme elucidating the effects of a DAO inhibition in clinical situations, we first investigated the effect of a large number of drugs, commonly used in an intensive care unit, on human and dog intestinal diamine oxidase in vitro.…”

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confidence: 99%

Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: Relevance for clinical side effects?

et al. 1985

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Three hundred and forty-one drugs, commonly used in intensive care units (ICU), were chosen for an investigation of possible activation or inhibition of the histamine metabolizing enzyme diamine oxidase (DAO). After examination of 164 substances, using both canine and human DAO in an in vitro screening test, 61 agents inhibited DAO activity to various degrees. Of these, 44 inhibited the enzyme from both species, 4 inhibited the canine enzyme only and 13 the human DAO only. No compound tested was able to enhance the enzyme activity. The inhibiting agents included representatives of all major therapeutic groups. A particularly strong inhibition was observed with the neuromuscular blocking drugs d-tubocurarine, pancuronium and alcuronium, however, the other commonly used neuromuscular blocking drug, suxamethonium, was without effect. Similarly with the cephalosporines, cefotiame and cefuroxime caused a marked inhibition of the human DAO activity, whereas another regularly-used substance of this class, cefotaxime, inhibited neither the human nor the canine enzyme in concentrations up to 10(-3) M. The observation that within a given therapeutic group some members inhibit and others do not, could be useful in choosing a therapy concept which minimizes the risk of a more severe 'histamine' reaction in seriously ill patients.

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“…The results reported in this paper show that DAO activity, that is implicated in the terminal catabolism of polyamines [19] and in the regulation of histamine levels under physiological and pathophysiological conditions [20][21][22][23], is influenced in maternal and fetal tissues by an acute intake of ethanol at doses that are not deleterious for the rats [17]. Ethanol caused both in 12-and 18-day pregnant rats similar inhibitory effects on DAO activity in the liver, the principal organ for alcohol metabolism, and in plasma.…”

Section: Discussionmentioning

confidence: 99%

Effect of acute ethanol administration on diamine oxidase activity in maternal, embryonal and fetal tissues

1987

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Pregnant rats were acutely treated with ethanol to study the influence of this drug on diamine oxidase activity of maternal, embryonal, and fetal tissues. When ethanol was given on day 12 of gestation, enzyme activity was unmodified in placenta and embryo, whereas it was reduced by 38 and 31%, respectively, in maternal liver and plasma at 3 h. When ethanol was given on day 18 of gestation, diamine oxidase activity diminished in maternal liver, plasma and placenta by about 35-40% at 6 h. Moreover, in the fetus ethanol caused a 35% diminution of enzyme activity in liver at 6 h and a 45% stimulation in brain at 3 h, and of about 65% at 6-12 h. These data may be of interest in view of the physiological role of diamine oxidase in the oxidation of the large amounts of amines produced during pregnancy.

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Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion

Cited by 31 publications

References 13 publications

Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.

Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.

Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: Relevance for clinical side effects?

Effect of acute ethanol administration on diamine oxidase activity in maternal, embryonal and fetal tissues

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