“…The most often used parameters of response to therapy were the reduction in the maximum standardized uptake value (SUV) or the peak standardized uptake lean mass (SUL) [ 8 – 16 , 18 ]. In particular, reductions in SUV max [or the regression index (RI)] of more than 50% were associated with a more favorable response to therapy than in the case of smaller reductions [ 8 , 10 , 11 , 14 , 15 , 18 ]. In two studies, changes in metabolic volume parameters or other specific criteria (i.e., PET response criteria in solid tumors—PERCIST or SUV max × blood glucose level/100−SUV gluc ) were also used to assess response to neoadjuvant therapy [ 13 , 16 ], demonstrating the additional value of alternative PET metrics in predicting and assessing response to therapy.…”