1971
DOI: 10.1136/jcp.24.3.244
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Diagnostic value of the serum folate assay

Abstract: SYNOPSISThe diagnostic value of the serum folate assay has been assessed in 90 patients, each of whom had a macrocytic anaemia and a low serum vitamin B12 level. Twenty-nine (32%) patients were found to have anaemia due primarily to folate deficiency. The cause of the low serum vitamin B12 levels is uncertain in the 22 (25%) patients with normal or borderline vitamin B12 absorption.The effect of folic acid therapy was studied in four of these patients, and in each case the serum vitamin B12 rose slowly to a no… Show more

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Cited by 10 publications
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“…Patients with PA usually have a normal or raised serum folate; a low serum level, evidencc of folate deficiency, is uncommon (Chanarin, 1969;Forshaw & Harwood, 1971). However, the altered handling of injected folic acid (Spray et a!, 1951; Chanarin et al, 1958) and the changes in amino-acid synthesis and excretion (Herbert et al, 1964;Zalusky & Herbert, 1961 ;Parry, 1969;Ellegaard & Esmann, 1973) indicate that vitamin B1 deficiency frequently results in a functional folate deficiency.…”
Section: Discussionmentioning
confidence: 99%
“…Patients with PA usually have a normal or raised serum folate; a low serum level, evidencc of folate deficiency, is uncommon (Chanarin, 1969;Forshaw & Harwood, 1971). However, the altered handling of injected folic acid (Spray et a!, 1951; Chanarin et al, 1958) and the changes in amino-acid synthesis and excretion (Herbert et al, 1964;Zalusky & Herbert, 1961 ;Parry, 1969;Ellegaard & Esmann, 1973) indicate that vitamin B1 deficiency frequently results in a functional folate deficiency.…”
Section: Discussionmentioning
confidence: 99%