Diagnostic Value of Serum Levels of IL-22, IL-23, and IL-17 for Idiopathic Pulmonary Fibrosis Associated with Lung Cancer

Abstract

Background Correlations between idiopathic pulmonary fibrosis (IPF) and lung cancer have been discussed in many previous studies. In the present work, we evaluated the potential diagnostic value of serum levels of Th17 cell-related cytokines for the detection of lung cancer-associated IPF. Methods Fifty-six patients who had been diagnosed with lung cancer-associated IPF were enrolled, and 59 patients with lung cancer but without IPF were also enrolled, and 60 healthy volunteers were served as the control group. The expression of IL-22, IL-23, and IL-17 was evaluated by enzyme-linked immunosorbent assay (ELISA) kits. Results We observed that IL-22, IL-23 as well as IL-17 were significantly increased in the serum of lung cancer patients associated IPF; moreover, the results of ROC curve showed that the expression of IL-22, IL-23 and IL-17 can distinguish the lung cancer patients with lung cancer-associated IPF group; finally, the expression of IL-22, IL-23 and IL-17 was positively correlated with the degree of differentiation and metathesis of the tumor. Conclusion In conclusion, we first reported that IL-22, IL-23 and IL-17 were elevated in the serum of patients with lung cancer-associated IPF, and our data may provide novel evidence for the prevention and treatment of lung cancer-associated IPF.

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

“…Our findings may offer new support for preventing and managing lung tumor-associated IPF (idiopathic pulmonary fibrosis), which Zhang et al. first discovered to have higher levels of IL-22, IL-23, and IL-17 in the serum of patients with IPF ( 54 ). According to several recent studies, interleukin-33 has been linked to the advancement of lung cancer and can have opposing effects on the disease depending on the circumstances ( 3 ).…”

“…In a bioinformatics study, a Novel investigation found that KLRK1 is a prognostic and diagnostic biomarker for lung cancer ( 54 ). A homodimeric lectin-like receptor, KLRK1, encodes NKG2D.…”

“…Phase I/II lung adenocarcinoma (P = 0.0094), older patients (P = 0.0072), male (P = 0.0033), and KLRK1 were all found to have substantial predictive significance. In phase I/II lung adenocarcinoma tumor individuals (P = 0.0025) and older patients (P = 0.012), KLRK1 was found to have substantial predictive significance ( 54 ).…”

Diagnostic value of IL-22, IL-23, and IL-17 for NK/T cell lymphoma

“…However, in liver cancer, the poor prognosis of patients is more related to Th17 / IL-17 in the tumor microenvironment (44,45), and the crucial function of Th17 / IL-17 on aggravating liver disease and promoting inflammation has also been reported (46)(47)(48). Several studies have suggested that IL-22 plays a protective role in hepatocyte injury and is able to promote hepatocyte regeneration (49)(50)(51). Furthermore, the IL-22 receptor is highly expressed in hepatocytes, suggesting that the important effector cells of IL-22 are hepatocytes.…”