Diagnostic value of screening enzyme immunoassays compared to indirect immunofluorescence for anti-nuclear antibodies in patients with systemic rheumatic diseases: A systematic review and meta-analysis

Jeong, Seri; Yang, Dahae; Park, Sung Sup; Kim, Geun Tae; Kim, Hyun Sook; Ahn, Hyeong Sik; Kim, Hyun Jung

doi:10.1016/j.semarthrit.2018.01.011

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…First, heterogeneity of included studies stemming from study populations, the timing of sampling collection, and applied RATs and rRT-PCR assays might affect the results of this meta-analysis. Subgroup analyses and a random effect model were conducted to overcome this limitation [ 57 , 58 ]. Second, publication bias could not be evaluated well because of the lack of included studies and techniques for the detection of the accuracy of diagnostic tests.…”

Section: Discussionmentioning

confidence: 99%

Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis

Kim

Sung

Lee

et al. 2022

Viruses

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Rapid antigen tests (RATs) for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are widely used in the Coronavirus disease 2019 (COVID-19) pandemic caused by diverse variants. Information on the real-world performance of RATs for variants is urgently needed for decision makers. Systematic searches of the available literature and updates were conducted in PubMed, Ovid-MEDLINE, Ovid-EMBASE, CENTRAL, and KMBASE for articles evaluating the accuracy of instrument-free RATs for variants up until 14 March 2022. A bivariate random effects model was utilized to calculate pooled diagnostic values in comparison with real-time reverse transcription-polymerase chain reaction as the reference test. A total of 7562 samples from six studies were available for the meta-analysis. The overall pooled sensitivity and specificity of RATs for variants were 69.7% (95% confidence interval [CI] = 62.5% to 76.1%) and 100.0% (95% CI = 98.8% to 100.0%), respectively. When an additional 2179 samples from seven studies reporting sensitivities only were assessed, the pooled sensitivity dropped to 50.0% (95% CI = 44.0% to 55.0%). These findings suggest reassessment and monitoring of the diagnostic utility of RATs for variants, especially for the sensitivity aspect, to facilitate appropriate diagnosis and management of COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis

Kim

Sung

Lee

et al. 2022

Viruses

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“…Previous studies reported risk factors for poor survival in SSc such as male sex, diffuse cutaneous subtype, age at disease onset, African origin, presence of anti-Scl-70 antibodies, and specific organ involvement. Identifying autoantibodies is clinically useful in helping diagnosis and in predicting the development of certain clinical manifestations and prognosis (18). ACA is associated with limited cutaneous involvement and PAH, whereas anti-Scl70 antibodies are associated with diffuse skin involvement and pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 99%

What do simple hematological parameters tell us in patients with systemic sclerosis?

Tezcan

Turan

Yılmaz

et al. 2020

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction: Systemic sclerosis (SSc) or scleroderma is a clinically heterogeneous disease. Autoantibodies associated with different clinical features may help in predicting organ involvement. Complete blood count (CBC) parameters and neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), and platelet/lymphocyte (PLR) ratios, which are considered biomarkers of systemic inflammation, have been reported many times in various rheumatologic diseases. Studies related to the usefulness of the CBC to assess the severity of SSc are still lacking. This study seeks to determine whether CBC parameters associated with organ involvement, when evaluated together with clinical features and autoantibodies, can additionally contribute to risk estimation. Methods: Adult patients with SSc (n = 130) and healthy control (n = 129) groups were enrolled in the study. Epidemiological, clinical, laboratory, and radiological findings were obtained by examining patient records. Results: PLR, NLR, and MLR were related to organ involvement. Statistically significant results were obtained with hemoglobin (≤ 13.0 g/dl), lymphocyte count (≤ 1,900 × 10 3 /ml), and mean platelet volume (≤ 8.0 fl) to estimate the risk of interstitial lung disease (p < 0.05). When the lymphocyte count was 1,400 (10 3 /ml) or less, there was a significantly greater risk of pulmonary hypertension. Neutrophil volume ≤ 141 indicated gastrointestinal tract involvement. Conclusions: Simple hematological parameters can be used for predicting SSc-related organ involvements.

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Laboratory Tests in Nephrology

Shendi

2022

Primer on Nephrology

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Diagnostic value of screening enzyme immunoassays compared to indirect immunofluorescence for anti-nuclear antibodies in patients with systemic rheumatic diseases: A systematic review and meta-analysis

Cited by 6 publications

References 42 publications

Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis

Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis

What do simple hematological parameters tell us in patients with systemic sclerosis?

Laboratory Tests in Nephrology

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