Diagnostic value of PIVKA-II and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma

Abstract

Serum PIVKA-II might be a better tumor marker than AFP, and its combination with AFP may enhance the early detection of HCC in patients with CHB.

Clinical value of LHPP‐associated microRNAs combined with protein induced by vitamin K deficiency or antagonist‐II in the diagnosis of alpha‐fetoprotein‐negative hepatocellular carcinoma

“…In recent years, PIVKA-II is considered to be a novel serological marker for HCC. 6,23 Our results indicated that PIVKA-II was significantly higher in AFP-NHCC patients and were useful for distinguishing AFP-NHCC from cirrhosis and controls, and the sensitivity was 65.4%, the specificity was 84.6%, which was consistent with previous research results. 23 In our research, miR-363-5p was the most effective indicator (AUC = 0.901) for the diagnosis of AFP-NHCC than miR-765 (AUC = 0.838) and PIVKA-II (AUC = 0.749), but its sensitivity (78.5%) was unsatisfactory.…”

“…This study found that serum levels of miR‐363‐5p and miR‐765 in patients with AFP‐NHCC were significantly higher than those in cirrhosis and controls and were related to differentiation, tumor size, and TNM stage, confirming that they are oncogenes in HCC. In recent years, PIVKA‐II is considered to be a novel serological marker for HCC . Our results indicated that PIVKA‐II was significantly higher in AFP‐NHCC patients and were useful for distinguishing AFP‐NHCC from cirrhosis and controls, and the sensitivity was 65.4%, the specificity was 84.6%, which was consistent with previous research results .…”

“…Protein induced by vitamin K deficiency or antagonist‐II (PIVKA‐II) is believed to be a suitable biomarker specific for HCC . However, the sensitivity of PIVKA‐II is still not satisfactory . In addition, due to the small size of the AFP‐NHCC tumor, imaging examination is prone to miss.…”

“…5 However, the sensitivity of PIVKA-II is still not satisfactory. 6 In addition, due to the small size of the AFP-NHCC tumor, imaging examination is prone to miss. It is reported that the diagnostic rates of AFP-NHCC patients by CT, MRI, and B ultrasound are about 50.9%, 50.0%, and 10.4%, respectively.…”

Vitamin K: A potential Liver Cancer treatment way

“…Using PIVKA-II in combination with AFP has been reported to improve accuracy [14]. Other studies looking exclusively at hepatitis B infected individuals suggest PIVKA-II is superior to AFP, and that the combination of both measures may enhance early detection [15]. A recent study comprising roughly 2 000 participants concluded that 230 HCC cases would have been neglected if using AFP alone, and that PIVKA-II levels increased over a year before image discovery [16].…”