Diagnostic Value of Peritumoral Minimum Apparent Diffusion Coefficient for Differentiation of Glioblastoma Multiforme From Solitary Metastatic Lesions

Lee, Eun Ja; terBrugge, Karel G.; Mikulis, David J.; Choi, Dae Seob; Bae, Jong Myon; Lee, Seon Kyu; Moon, Seokoh

doi:10.2214/ajr.10.4752

Cited by 137 publications

(140 citation statements)

References 18 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…The present definition of minimum ADC is the lowest value selected from multiple ROIs drawn manually along the border of the lesion on each consecutive tumor-containing slices, including the whole tumor volume, not the lowest value corresponding to a pixel in one ROI surrounding the mass. The regions with minimum ADCs have been suggested to reflect the highest tumor cell density or the most proliferative portion of the tumor (20).…”

Section: Discussionmentioning

confidence: 99%

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Erden²,

No³

et al. 2013

Diagn Interv Radiol

View full text Add to dashboard Cite

ABDOMINAL IMAGINGORIGINAL ARTICLE PURPOSE The aim of this study was to retrospectively assess the correlation between minimum apparent diffusion coefficient (ADC min ) values obtained from diffusion-weighted magnetic resonance imaging (MRI) and maximum standardized uptake values (SUV max ) obtained from positron emission tomography-computed tomography (PET-CT) in rectal cancer. MATERIALS AND METHODSForty-one patients with pathologically confirmed rectal adenocarcinoma were included in this study. For preoperative staging, PET-CT and pelvic MRI with diffusion-weighted imaging were performed within one week (mean time interval, 3±1 day). For ADC measurements, the region of interest (ROI) was manually drawn along the border of each hyperintense tumor on b=1000 s/mm 2 images. After repeating this procedure on each consecutive tumor-containing slice to cover the entire tumoral area, ROIs were copied to ADC maps. ADC min was determined as the lowest ADC value among all ROIs in each tumor. For SUV max measurements, whole-body images were assessed visually on transaxial, sagittal, and coronal images. ROIs were determined from the lesions observed on each slice, and SUV max values were calculated automatically. The mean values of ADC min and SUV max were compared using Spearman's test. RESULTSThe mean ADC min was 0.62±0.19×10 -3 mm 2 /s (range, 0.368-1.227×10 -3 mm 2 /s), the mean SUV max was 20.07±9.3 (range, 4.3-49.5). A significant negative correlation was found between ADC min and SUV max (r=-0.347; P = 0.026). CONCLUSIONThere was a significant negative correlation between the ADC min and SUV max values in rectal adenocarcinomas. D iffusion-weighted imaging (DWI) is a widely used technique for disease evaluation in oncology (1, 2). In rectal cancer, the applications of DWI include tumor detection, tumor characterization, distinguishing tumor tissue from nontumor tissue, and monitoring and predicting treatment response (3-8). For local staging of rectal cancer, adding DWI to conventional magnetic resonance imaging (MRI) yields better identification of tumor borders and locoregional lymph nodes than conventional MRI alone (9, 10).The apparent diffusion coefficient (ADC) map obtained from DWI shows the freedom of water diffusion, and values calculated on the map are useful parameters in tissue characterization. By performing diffusion-weighted (DW) MRI with at least two diffusion weightings, or b values, the differential signal attenuation at different b values can be used to calculate the ADC (2). Regardless of the tumor type and location, the ADC values reflect tumor morphology, including the cellular density, integrity of cell membrane, and nuclear-to-cytoplasm ratio (11,12).Positron emission tomography/computed tomography (PET-CT) has become a crucial method in cancer imaging, both for diagnosis and staging, as well as for offering prognostic information based on tumor response. In PET-CT, the standardized uptake value (SUV) is a measure of fluorodeoxyglucose (FDG) uptake, which has been shown to be helpful in estab...

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Erden²,

No³

et al. 2013

Diagn Interv Radiol

View full text Add to dashboard Cite

show abstract

“…11,12 The third type is focused on 3 locations: the enhancing part of the tumor, regions with peritumoral T2 prolongation, and the necrotic areas within the tumor. 7 With regard to the enhancing part of the tumor, DTI and perfusion metrics showed inconsistent conclusions, with some authors believing there was no difference between the 2 types of tumors, 10,13,16 contrary to the others. 6,8,14,15 As for the peritumoral T2 prolongation, the results were also controversial.…”

Section: Figmentioning

confidence: 99%

“…2,3 Therefore, it is thought to be very difficult to distinguish between these 2 types of tumors with routine MR imaging alone. [4][5][6] Many studies have focused on other advanced MR imaging modalities, such as DTI, 3,5,7,8 DWI, 9,10 PWI, 6,[11][12][13][14][15][16] and MR spectroscopy, 17 to explore the differentiating characteristics.…”

mentioning

confidence: 99%

“…3,5,8 DWI research demonstrated that the mean minimum ADC values and mean ADC ratios in the peritumoral regions of GBM were significantly higher than those in MET. 10 With PWI, most of the studies showed that the CBV of GBM was significantly higher than in MET, either in the peritumoral region [11][12][13] or in the enhanced region. 14 An MR spectroscopy study indicated that lipid and macromolecule signals were significantly different between the 2 types of tumors.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Differentiation between Brain Glioblastoma Multiforme and Solitary Metastasis: Qualitative and Quantitative Analysis Based on Routine MR Imaging

Chen

Yin

Lin

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…Specifically, although peritumoral oedema is common in both metastases and primary brain malignancies, the ADC values in the peritumoral oedema of metastases have been shown to be higher than those of primary brain malignancies. It is believed that this difference is owing to the more infiltrative nature of primary malignancies, which results in an "infiltrative oedema" as opposed to simple vasogenic oedema [67].…”

Section: Neoplastic Malignant Metastasesmentioning

confidence: 99%

“Dazed and diffused”: making sense of diffusion abnormalities in neurologic pathologies

O’Connor

Barest²,

Moritani³

et al. 2013

BJR

View full text Add to dashboard Cite

To review diffusion abnormalities seen in diffusion-weighted MRI in neurological pathologies. We examine the clinical significance of the abnormalities in a broad spectrum of neurological diseases and highlight our current understanding of their causes. Diffusion abnormalities seen on diffusion-weighted MRI can play an important role in the diagnosis and follow-up of a broad spectrum of neurological diseases. A thorough understanding of the appearance and significance of these abnormalities is critical in patient management.Although the best known use of diffusion-weighted imaging (DWI) in MRI of the brain is detection of acute vaso-occlusive infarct, diffusion abnormalities occur in a wide spectrum of neurological pathologies. These diffusion abnormalities provide information that can directly affect the management of a patient, whether identifying pathology that would otherwise go unrecognised, narrowing a broad differential diagnosis, identifying conditions that require emergent intervention, evaluating response to treatment or providing prognostic information about a patient's expected clinical course. In this review, we explain the significance of diffusion abnormalities in a variety of neurological diseases and highlight our current understanding of the causes of these diffusion abnormalities.

show abstract

Diagnostic Value of Peritumoral Minimum Apparent Diffusion Coefficient for Differentiation of Glioblastoma Multiforme From Solitary Metastatic Lesions

Abstract: Although the characteristics of solitary metastasis and glioblastoma multiforme may be similar on conventional MRI, DWI can offer diagnostic information to distinguish between the tumors.

Cited by 137 publications

References 18 publications

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Differentiation between Brain Glioblastoma Multiforme and Solitary Metastasis: Qualitative and Quantitative Analysis Based on Routine MR Imaging

“Dazed and diffused”: making sense of diffusion abnormalities in neurologic pathologies

Contact Info

Product

Resources

About