Diagnostic value of levels of presepsin (soluble CD14-subtype) in febrile neutropenia in patients with hematological disorders

Abstract

In FN, presepsin may be an earlier and more sensitive indicator of bacterial infection than PCT.

Diagnostic performance of procalcitonin, presepsin, and C‐reactive protein in patients with hematological malignancies

“…11,21 Few studies have evaluated the presepsin levels of patients with hematological malignancies, even though they frequently suffer severe infections or sepsis during the clinical courses of their diseases. 8,12 Among the patients with hematological malignancies examined in the current study, the patients with infections tended to exhibit higher presepsin levels, but the difference was not significant. And presepsin showed lower AUC than PCT (Figure 4).…”

“…Neutropenia was defined as a neutrophil count of <0.5×10 9 /L or a neutrophil count of <1.0×10 9 /L in patients whose neutrophil counts were expected to decline to <0.5×10 9 /L. Fever was defined as an axillary temperature of ≥37.5°C based on a single measurement as previously reported …”

“…Elevated presepsin levels in the peripheral blood have widely been used as a biomarker of sepsis, especially in the field of critical care medicine . It was reported that presepsin levels are related to the severity of sepsis and can be used to predict the prognosis of such patients . However, the usefulness of presepsin in patients with hematological malignancies, including those that develop febrile neutropenia, remains unclear.…”

“…Fever was defined as an axillary temperature of ≥37.5°C based on a single measurement as previously reported. 12,15 In some of analyses, we classified the febrile episodes by the absence or presence of infections or neutropenia (see text).…”

Research update for articles published in EJCI in 2015

“…However, procalcitonin (PCT) and lipopolysaccharide-binding protein (LBP) presented a promising performance for identifying microbiologically confirmed bacteraemia, which was recently also observed in other neutropenia settings, including paediatric patients [47][48][49]. Presepsin (sCD14) might be used in addition to PCT to detect bacteraemia in these patients, which might have a better discriminatory capacity [49].…”