Diagnostic value of clinical indices in syndrome differentiation of chronic hepatitis B: an exploration based on receiver operating characteristic curves and stepwise discriminant analysis

Zhao, Yu; Peng, Jinghua; Li, Xuemei; Fu, Qilin; Cui, Tuan; Li, Qi; Tang, Yajun; Feng, Qinglai; Zhang, Hua; Zhou, Hua; Hu, Yiyang

doi:10.3736/jcim20121208

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…As was shown in Tables 4, 5, and 6, there is no significant correlation between most metabolites and clinical indicators except for minority indexes, which may illustrate little relationship between the objective material basis related to tongue coating and the clinical indicators. Our earlier study showed that the clinical indicators had limited value in determining TCM syndromes in patients with chronic hepatitis B [38]. In addition, among these clinical indicators there were no significant differences between Group A and Group B.…”

Section: Discussionmentioning

confidence: 98%

Differences in Metabolites of Different Tongue Coatings in Patients with Chronic Hepatitis B

Zhao

Gou

Dai

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Tongue coating is one of the important foundations of tongue diagnosis in traditional Chinese medicine (TCM) and plays an important role in reflecting the occurrence, development, and prognosis of the disease. However, its material basis is still poorly understood. In this study, a urinary metabonomic method based on gas chromatography coupled to mass spectrometry (GC/MS) was developed. The distinct clustering in metabolic profile was observed from Group A (thick yellow coating in patients with chronic hepatitis B), Group B (thick white coating in patients with chronic hepatitis B), and Group C (thin white coating with healthy humans) using orthogonal projections to latent structures (OPLS). Based on the variable of importance in the project (VIP) values, some significantly changed metabolites have been identified. These changes were related to the disturbance in energy metabolism, amino acid metabolism, nucleotide metabolism, and gut microflora, which were helpful to understand the material basis leading to the formation of tongue coating. This study demonstrated that tongue coating may have an objective material basis.

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Section: Discussionmentioning

confidence: 98%

Differences in Metabolites of Different Tongue Coatings in Patients with Chronic Hepatitis B

Zhao

Gou

Dai

et al. 2013

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…For example, syndromes of liver depression, damp heat and blood stasis can be often perceived in SD patients 9 . Epidemic studies indicated that the most common complex syndromes in HBV-infection patients were accumulated dampness-heat syndrome (ADHS), spleen deficiency with liver depression (SDLD) and blood stasis vessel obstruction syndrome (BSVO) 10,11 . The complex syndrome phenotypes pose a great challenge to differential diagnosis.…”

Section: Traditionalmentioning

confidence: 99%

Syndrome differentiation of chronic hepatitis B patients by integrating routine clinical laboratory and plasma metabolomics analysis data

Huang

Guo²,

Hang-yu³

et al. 2020

MRAJ

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Purpose: Traditional Chinese Medicines (TCMs) has been officially approved for chronic hepatitis B infection treatment in China. Correct syndrome differentiation is the key prerequisite for rational prescribing TCMs. Unfortunately, TCM physicians have scarcities of objective measures for syndrome differentiation and their diagnosis exclusively relies on individual experience. This study aimed to find out some objective parameters to aid syndrome differentiation. Methods: Three commonly encountered clinical syndromes named accumulated dampness-heat syndrome (ADHS), spleen deficiency with liver depression (SDLD) and blood stasis vessel obstruction syndrome (BSVO) were selected. 64 qualified patients with definite syndromes were enrolled and their plasma amino acids and lipids were profiled by metabolomics analysis. Additionally, their routine clinical laboratory parameters were also collected. Results: Through orthogonal partial least squares-discriminant analysis, the three syndromes could be properly differentiated. The differential parameters between every two syndromes were screened out. Most of them were of the small molecular metabolites. A distinct difference was found between ADHS and the other two syndromes. BSVO and SDLD showed relatively less discrepancy. Furthermore, it was deduced that sphingomyelin metabolism might dominate ADHS phenotype, and platelet functions might affect SDLD phenotype to some extent. Conclusions: These findings provided primary evidence for the objective classification of varied syndromes of chronic hepatitis B patients and proved that metabolomics analysis might be a valuable tool to aid syndrome differentiation in some circumstances.

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Power Information System Risk Assessment Method Based on Genetic Algorithms and Neural Network

Yang

Fan

2014

AMM

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In order to scientifically and accurately evaluate power information system, the new power information risk evaluation method based on the genetic algorithm and BP neural network is presented. The method combining the genetic algorithm and BP algorithm can be used to train the feedforward neural network , namely, first , to use the genetic algorithm to do the global training, then ,to use BP algorithm to do local precise training ,which not only overcomes the drawbacks of the traditional BP network (the training time is long, and the network is easy to fall to local extremum),but also improves the global convergence efficiency. The method was adopted to evaluate the power information system. And findings identify that the new method has distinctive convergence speed and high predicition accuracy, which provides a new concept for power information system risk assessment.

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Diagnostic value of clinical indices in syndrome differentiation of chronic hepatitis B: an exploration based on receiver operating characteristic curves and stepwise discriminant analysis

Abstract: Neither single differential index nor multiple differential indices determinant models provided appropriate determination of the TCM syndromes of patients with chronic hepatitis B, suggesting that clinical indicators have limited value in determining traditional Chinese medicine syndromes.

Cited by 3 publications

References 4 publications

Differences in Metabolites of Different Tongue Coatings in Patients with Chronic Hepatitis B

Differences in Metabolites of Different Tongue Coatings in Patients with Chronic Hepatitis B

Syndrome differentiation of chronic hepatitis B patients by integrating routine clinical laboratory and plasma metabolomics analysis data

Power Information System Risk Assessment Method Based on Genetic Algorithms and Neural Network

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