Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging—a comprehensive overview

Delgado, Anna Falk; Westen, Danielle van; Nilsson, Markus; Knutsson, Linda; Sundgren, Pia C.; Larsson, Elna‐Marie

doi:10.1186/s13244-019-0771-1

Cited by 51 publications

(48 citation statements)

References 148 publications

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“…However, concerns regarding the use of GBCAs for medical imaging studies have resulted in research studies evaluating techniques to reduce their use, including a DL approach to reduce the dosage of GBCAs for contrast-enhanced MRI. [31][32][33] Currently, two full doses of GBCAs are applied to acquire perfusion maps of K trans and rCBV from DCE and DSC MRI, respectively. Dual-echo DSC MRI is one option to obtain both rCBV and K trans .…”

Section: F I G U R Ementioning

confidence: 99%

Synthetic generation of DSC‐MRI‐derived relative CBV maps from DCE MRI of brain tumors

Sanders

Chen

Johnson

et al. 2020

Magnetic Resonance in Med

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Purpose: Perfusion MRI with gadolinium-based contrast agents is useful for diagnosis and treatment response evaluation of brain tumors. Dynamic susceptibility contrast (DSC) MRI and dynamic contrast enhanced (DCE) MRI are two gadolinium-based contrast agent perfusion imaging techniques that provide complementary information about the tumor vasculature. However, each requires a separate administration of a gadolinium-based contrast agent. The purpose of this retrospective study was to determine the feasibility of synthesizing relative cerebral blood volume (rCBV) maps, as computed from DSC MRI, from DCE MRI of brain tumors. Methods: One hundred nine brain-tumor patients underwent both DCE and DSC MRI. Relative CBV maps were computed from the DSC MRI, and blood plasma volume fraction maps were computed from the DCE MRIs. Conditional generative adversarial networks were developed to synthesize rCBV maps from the DCE MRIs. Tumor-to-white matter ratios were calculated from real rCBV, synthetic rCBV, and plasma volume fraction maps and compared using correlation analysis. Real and synthetic rCBV in white and gray matter regions were also compared. Results: Pearson correlation analysis showed that both the tumor rCBV and tumorto-white matter ratios in the synthetic and real rCBV maps were strongly correlated (ρ = 0.87, P < .05 and ρ = 0.86, P < .05, respectively). Tumor plasma volume fraction and real rCBV were not strongly correlated (ρ = 0.47). Bland-Altman analysis showed a mean difference between the synthetic and real rCBV tumor-to-white matter ratios of 0.20 with a 95% confidence interval of ±0.47. Conclusion: Realistic rCBV maps can be synthesized from DCE MRI and contain quantitative information, enabling robust brain-tumor perfusion imaging of DSC and DCE parameters with a single gadolinium-based contrast agent administration.

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Section: F I G U R Ementioning

confidence: 99%

Synthetic generation of DSC‐MRI‐derived relative CBV maps from DCE MRI of brain tumors

Sanders

Chen

Johnson

et al. 2020

Magnetic Resonance in Med

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“…According to these, GBCAs should only be used when absolutely necessary or in research settings with the appropriate guidance of protocols [60]. Therefore, efforts are ongoing to find new NCE methods which could potentially replace CE-MRI [61].…”

Section: Alternative Non-contrast-enhanced Techniques Of Mrimentioning

confidence: 99%

Role of gadolinium-based contrast agents in neurological disorders

Golec

Jakimów-Kostrzewa

Mruk

et al. 2020

Neurol Neurochir Pol.

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Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI) to help with the diagnostic and monitoring processes of many diseases, including neurological disorders. Initially, it was assumed that GBCAs carry minimal risk, are safe and well tolerated. But recent reports of GBCA-associated deposition in many body tissues have raised concerns about the broader health impacts of gadolinium exposure. The aim of this review was to summarise knowledge regarding gadolinium deposition, primarily in the brain structures, and of potential GBCA-associated toxicity. Moreover, we discuss the current recommendations on the use of GBCAs, as well as alternative contrast agents and imaging techniques.

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“…As discussed, accurate DBS implantation requires careful trajectory planning and identification of vasculature to limit the risk of hemorrhagic complications. Visualization of larger venous architecture is most commonly achieved with an anatomical T1w scan with added gadolinium [ 119 , 120 ]. In its most basic form, T1w can be viewed as an anatomical scan that approximates the appearance of macroscopic tissues.…”

Section: Sequence Types and Contrastsmentioning

confidence: 99%

Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease Patients

Isaacs

Keuken

Alkemade

et al. 2020

JCM

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Deep brain stimulation (DBS) of the subthalamic nucleus is a neurosurgical intervention for Parkinson’s disease patients who no longer appropriately respond to drug treatments. A small fraction of patients will fail to respond to DBS, develop psychiatric and cognitive side-effects, or incur surgery-related complications such as infections and hemorrhagic events. In these cases, DBS may require recalibration, reimplantation, or removal. These negative responses to treatment can partly be attributed to suboptimal pre-operative planning procedures via direct targeting through low-field and low-resolution magnetic resonance imaging (MRI). One solution for increasing the success and efficacy of DBS is to optimize preoperative planning procedures via sophisticated neuroimaging techniques such as high-resolution MRI and higher field strengths to improve visualization of DBS targets and vasculature. We discuss targeting approaches, MRI acquisition, parameters, and post-acquisition analyses. Additionally, we highlight a number of approaches including the use of ultra-high field (UHF) MRI to overcome limitations of standard settings. There is a trade-off between spatial resolution, motion artifacts, and acquisition time, which could potentially be dissolved through the use of UHF-MRI. Image registration, correction, and post-processing techniques may require combined expertise of traditional radiologists, clinicians, and fundamental researchers. The optimization of pre-operative planning with MRI can therefore be best achieved through direct collaboration between researchers and clinicians.

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Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging—a comprehensive overview

Cited by 51 publications

References 148 publications

Synthetic generation of DSC‐MRI‐derived relative CBV maps from DCE MRI of brain tumors

Synthetic generation of DSC‐MRI‐derived relative CBV maps from DCE MRI of brain tumors

Role of gadolinium-based contrast agents in neurological disorders

Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease Patients

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