Diagnostic Utility of Selective Upper Tract Urinary Cytology: A Systematic Review and Meta-analysis of the Literature

Potretzke, Aaron M.; Knight, B. Alexander; Vetter, Joel; Anderson, Barrett G.; Hardi, Angela; Bhayani, Sam B.; Figenshau, R. Sherburne

doi:10.1016/j.urology.2016.04.030

Cited by 50 publications

(45 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation was again found in this study. As clearly illustrated in Table 3, there was only a 31.8% detection rate for low grade urothelial carcinoma with traditional urine cytology while 100% of high grade urothelial carcinoma detected by urine cytology and these results are similar to results of [20,21].…”

Section: Percent (Number Of Cases/total Number) Voided Urine Cytologysupporting

confidence: 66%

The Role of Cytologic Analysis in Follow-Up of Non-Muscle Invaisve Urothelial Cell Carcinoma in Relation to Cystoscopic Biopsy

Badary¹,

Reda²

2017

J Mol Biomark Diagn

View full text Add to dashboard Cite

Background: Bladder urothelial carcinoma has high recurrence rate so patients with bladder urothelial carcinoma have to be monitored thoroughly for disease recurrence, this makes bladder cancer one of the most expensive cancer types for the health care system. Voided urine cytology is the most commonly used noninvasive follow-up diagnostic tool. The purpose of this study was to assess the role of voided urine cytology for the follow-up of patients with non-muscle invasive urothelial carcinoma (NMIUC).

show abstract

Section: Percent (Number Of Cases/total Number) Voided Urine Cytologysupporting

confidence: 66%

The Role of Cytologic Analysis in Follow-Up of Non-Muscle Invaisve Urothelial Cell Carcinoma in Relation to Cystoscopic Biopsy

Badary¹,

Reda²

2017

J Mol Biomark Diagn

View full text Add to dashboard Cite

show abstract

“…The present study is, to our knowledge, the first report of the efficacy of 5‐ALA‐induced fluorescent selective upper urinary tract urinary cytology for the diagnosis of UTUC. According to a past systematic review and meta‐analysis, the sensitivity of conventional selective upper tract urinary cytology is 53.1%, specifically, 45.6% for low‐grade tumors and 69.9% for high‐grade tumors . In the present study, 5‐ALA‐induced fluorescent selective upper tract urinary cytology was more sensitive (90.4%) than conventional selective upper tract urinary cytology (60.3%), regardless of patient age, sex, pT stage and tumor grade.…”

Section: Discussionsupporting

confidence: 45%

High performance of 5‐aminolevulinic acid‐induced fluorescent selective upper tract urinary cytology

Yamamichi¹,

Nakata²,

Yoshimura³

et al. 2020

Int J of Urology

View full text Add to dashboard Cite

Objectives To investigate the efficacy of selective upper tract urinary cytology using extracorporeal 5‐aminolevulinic acid for the diagnosis of upper urinary tract urothelial carcinoma. Methods We evaluated 104 patients who underwent radical nephroureterectomy and were diagnosed pathologically as having upper urinary tract urothelial carcinoma between March 2013 and May 2019 in Osaka Rosai Hospital. Preoperatively, we collected upper tract urinary cytology from both sides, and compared the sensitivity and specificity between conventional urine cytology and 5‐aminolevulinic acid‐induced fluorescent urine cytology. Results The sensitivity of 5‐aminolevulinic acid‐induced fluorescent selective upper tract urinary cytology was significantly higher than conventional cytology (90.4% vs 66.3%, P < 0.001), whereas the specificity was equally high (100% vs 98.2%, P = 1.0). In more detailed analysis, the sensitivity of 5‐aminolevulinic acid‐induced fluorescent selective upper tract urinary cytology was significantly higher than that of conventional cytology unrelated to patients’ age (<76 years: 90.2% vs 68.6%, P = 0.013; ≥76 years: 90.6% vs 64.2%, P = 0.021), sex (male: 89.2% vs 67.5%, P = 0.001; female: 95.2% vs 61.9%, P = 0.02) or pT stage (pT1 or less: 91.4% vs 69.0%, P = 0.005; pT2 or more: 89.1% vs 63.0%, P = 0.006), tumor grade (high grade: 91.0% vs 70.5%, P = 0.002; low grade: 88.5% vs 53.8%, P = 0.013), and tended to be more efficacious for tumors that could not be detected by imaging techniques (83.3% vs 50.0%, P = 0.075). Conclusions 5‐Aminolevulinic acid‐induced fluorescent selective upper tract urinary cytology is more sensitive than conventional cytology for the diagnosis of upper urinary tract urothelial carcinoma, regardless of pT stage and tumor grade.

show abstract

“…We observed that if cytology cases with an either suspicious or positive for HGUC interpretation were considered as positive, we achieved almost 80% sensitivity in detecting HGUC with a specificity of over 90%. According to a recent meta‐analysis, the overall sensitivity and specificity of UUT cytology for detection of HGUC were 70% (95% CI: 56%‐81%) and 90% (95% CI: 85%‐93%), respectively . All these data were based non‐TPS cytology reporting system .…”

Section: Discussionmentioning

confidence: 99%

“…However, the value of UUT urinary cytology remains controversial. According to a recent review and meta‐analysis of the literature, although the overall specificity of selective UUT urinary cytology in diagnosing urothelial carcinoma was 90% with a range of 77%‐97%, the overall sensitivity was only 53% with a range of 21%‐77% …”

Section: Introductionmentioning

confidence: 99%

The Paris System for urine cytology in upper tract urothelial specimens: A comparative analysis with biopsy and surgical resection

Zheng

et al. 2017

Cytopathology

View full text Add to dashboard Cite

More than one-third of the UUT cytological cases were classified as AUC and approximately 1/15 as suspicious or positive for HGUC. Based on UUT cytology specimens, the risk of malignancy of each cytological diagnostic category of TPS was comparable to those reported in the literature. The use of TPS in evaluating UUT cytology specimens was specific and sensitive in identifying patients with HGUC by histology.

show abstract

Diagnostic Utility of Selective Upper Tract Urinary Cytology: A Systematic Review and Meta-analysis of the Literature

Cited by 50 publications

References 50 publications

The Role of Cytologic Analysis in Follow-Up of Non-Muscle Invaisve Urothelial Cell Carcinoma in Relation to Cystoscopic Biopsy

The Role of Cytologic Analysis in Follow-Up of Non-Muscle Invaisve Urothelial Cell Carcinoma in Relation to Cystoscopic Biopsy

High performance of 5‐aminolevulinic acid‐induced fluorescent selective upper tract urinary cytology

The Paris System for urine cytology in upper tract urothelial specimens: A comparative analysis with biopsy and surgical resection

Contact Info

Product

Resources

About