Diagnostic Utility of Labyrinth Capsule Bone Density in the Diagnosis of Otosclerosis With High Resolution Tomography

Puiggrós, Ignacio Viza; Granell, Enric Marco; Navarro, Carlos Calvo; Rovira, Mercè Bohé; Dotu, César Orús; Agustí, Miquel Quer

doi:10.1016/j.otoeng.2019.09.001

Cited by 6 publications

(10 citation statements)

References 20 publications

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“…The CT evaluation of the otic capsule bone density involved the measurement of the bone density using Hounsfield Units in three different regions of interest, two in the otic capsule (ROI 1 and 2), and one near the posterior edge of the petrous bone (ROI 3) in both case and control groups. This method has been used in previous studies (20)(21)(22)(23)(24) of otic capsule bone density in otosclerosis, but the present study is the first to assess its utility in PDTB patients. Nevertheless, otic capsule bone density was measured in PDTB by Monsell et al (19) using quantitative CT (QCT), who observed decreased bone mineral density in the cochlear capsule of PDTB patients in relation to controls.…”

Section: Discussionmentioning

confidence: 99%

“…They concluded that hearing impairment was related to loss of bone mineral density in the cochlear capsule (19). Bone mineral density in the otic capsule can be evaluated using either CT values measured in Hounsfield Units (HU) obtained from clinical CT (20)(21)(22)(23)(24) or QCT (25). Clinical CT is now replacing QCT as the tool for assessing bone mineral density (26,27).…”

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CT Assessment of Otic Capsule Bone Density in Paget's Disease of the Temporal Bone and Its Relationship With Hearing Loss

Amilibia

Pérez-Grau²,

Callejo³

et al. 2021

Otology &Amp; Neurotology

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Objectives:To study computed tomography findings in Paget's disease of temporal bone (PDTB) and analyze the relations between otic capsule bone mineral density values measured in Hounsfield Units (HU) and hearing loss (HL).Study Design:Observational case-control study.Setting:Tertiary referral center.Patients:Radiographically confirmed PDTB cases and control group.Intervention:Diagnostic.Main Outcome Measures:Hearing thresholds and computed tomography bone density values.Results:Twenty-three ears in the case group (PDTB) and 27 control ears were included. In the PDTB group, HL was found in 87% of the ears (43% mixed) and an air-conduction threshold of 50.7 dB (SD = 19.8). In the control group, 48% of the ears showed HL (7% mixed) and an air-conduction threshold of 34.5 dB (SD = 20.6) was found; the difference was statistically significant (p < 0.05). Measurements of bone density (HU) in the otic capsule (regions of interest [ROI] 1 and 2) and in the petrous bone (ROI 3) were significantly lower (p < 0.05) in the PDTB group than in controls.The PDTB group presented a significant association between otic capsule bone density in ROI 1 and mean otic capsule density with air and bone-conduction thresholds (p < 0.05). In controls, no association was observed between any density value and audiometric thresholds.Conclusion:PDTB patients showed more frequent HL, lower thresholds, and a higher proportion of mixed HL than controls. Bone density (HU) was decreased in all ROIs in PDTB patients in comparison with controls. Bone density in the otic capsule was associated with HL in PDTB patients, but no association was observed between bone density and HL in controls.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

CT Assessment of Otic Capsule Bone Density in Paget's Disease of the Temporal Bone and Its Relationship With Hearing Loss

Amilibia

Pérez-Grau²,

Callejo³

et al. 2021

Otology &Amp; Neurotology

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“…Anatomical factors wherein fissula ante fenestram is incriminated along with persisting remnants of embryonic cartilage [3,4]. of disease [3,4].…”

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“…Ribonucleic acid (RNA) of measles virus may be discerned within footplate of stapes upon ultrastructural examination and immunohistochemistry. Vaccination for measles virus may appear as a safeguard for occurrence of otosclerosis [3,4]. Additionally, factors such as menopause, trauma, bone dyscrasia or major surgery may initiate or aggravate otosclerosis [3,4].…”

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The Osseous Dissipation- Otosclerosis

Bajaj¹

2021

BJSTR

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Computed Tomography Density as a Bio-marker for Histologic Grade of Otosclerosis: A Human Temporal Bone Pathology Study

Quesnel

Ishai

Meehan³

et al. 2022

Otology &Amp; Neurotology

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HypothesisComputed tomography (CT) density measurement can be used to objectively distinguish otosclerosis from normal bone and to determine histologic grades of otosclerosis.BackgroundOtosclerosis can be seen on CT as subtle radiolucent areas. An objective radiologic measurement that corresponds to known otosclerosis pathology may improve diagnostic accuracy, and could be used as a radiologic biomarker for otosclerosis grade.MethodsA blinded, randomized evaluation of both histologic grade on histopathology slides and CT density measurement was performed on 78 human temporal bone specimens (31 with otosclerosis and 47 controls) that had undergone high-resolution multi-detector CT before histologic processing. Assessments were performed at 11 regions of interest (ROIs) in the otic capsule for each specimen.ResultsThe CT density measurement mean (Hounsfield Units) ± standard deviation for all ROIs (Nos. 1–9) was 2245 ± 854 for grade 0 (no otosclerosis, n = 711), 1896 ± 317 for grade 1 (inactive otosclerosis, n = 109), and 1632 ± 255 for grades 2 and 3 combined (mixed/active otosclerosis, n 35). There was a strong inverse correlation of CT density to histologic grade at ROIs Nos. 1–5 (ANOVA, p < 0.0001). The inter-rater reliability for CT density was very good (correlation coefficient 0.87, p < 0.05). ROC curves suggested a cut-off of 2,150HU to distinguish otosclerosis from normal bone, and 1,811HU to distinguish low grade from mixed/high grade otosclerosis.ConclusionsIn human temporal bone specimens, CT density may be used to distinguish normal bone from bone involved by otosclerosis. A higher histologic grade (i.e., indicating a more active otosclerotic focus) correlated with lower density.

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Diagnostic Utility of Labyrinth Capsule Bone Density in the Diagnosis of Otosclerosis With High Resolution Tomography

Cited by 6 publications

References 20 publications

CT Assessment of Otic Capsule Bone Density in Paget's Disease of the Temporal Bone and Its Relationship With Hearing Loss

CT Assessment of Otic Capsule Bone Density in Paget's Disease of the Temporal Bone and Its Relationship With Hearing Loss

The Osseous Dissipation- Otosclerosis

Computed Tomography Density as a Bio-marker for Histologic Grade of Otosclerosis: A Human Temporal Bone Pathology Study

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