Diagnostic utility of fine needle aspiration (FNA) cytology in HIV‐infected patients with lymphadenopathy

Reid, Ajc; Miller, R F; Kocjan, Gabrijela

doi:10.1046/j.1365-2303.1998.00149.x

Cited by 51 publications

(54 citation statements)

References 38 publications

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“…18 Diagnosis of reactive adenopathy with FNAC had a relatively low sensitivity compared to other aetiologies like TB and KS. This clearly depicts the diagnostic pitfalls of FNAC in diagnosis of reactive adenopathy as also reported by Reid et al 20 The number of patients with reactive adenopathy was however quite small, and this may have affected the result we got. Moreover, reactive adenitis has been questioned as a diagnosis 21 .…”

Section: Diagnostic Accuracysupporting

confidence: 83%

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Muyanja¹,

Kalyesubula²,

Namukwaya³

et al. 2015

Afr H. Sci.

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Background: Opportunistic infections and malignancies cause lymphadenopathy in HIV-infected patients. The use and accuracy of fine needle aspiration cytology in diagnosing of cervical lymphadenopathy among HIV-infected patients is not well studied in Uganda. Objective: The aim of this study was to determine the diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients in Uganda. Methods: We consecutively recruited adult HIV-infected patients with cervical lymphadenopathy admitted to Mulago Hospital medical wards. Clinical examination, fine needle aspiration and lymph node biopsy were performed. We estimated the sensitivity, specificity; negative and positive predictive values using histology as the gold standard. Results: We enrolled 108 patients with a mean age of 33 years (range, 18-60), 59% were men and mean CD4 was 83(range, 22-375) cells/mm

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Section: Diagnostic Accuracysupporting

confidence: 83%

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Muyanja¹,

Kalyesubula²,

Namukwaya³

et al. 2015

Afr H. Sci.

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“…The false-negative rate in other studies ranges from 2% to 9.2%. 1,4,7,8 Of these seven false-negative cases, six were diagnosed as reactive nodes on FNAC which later showed fibrocaseous nodes on biopsy. Possible reasons for discordance could be focal tubercular involvement of the nodes.…”

Section: Discussionmentioning

confidence: 99%

Role of fine-needle aspiration cytology in human immunodeficiency virus-associated lymphadenopathy: a cross-sectional study from northern India

Kumar¹,

Gupta²,

Sharma³

et al. 2014

Hong Kong Med J

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Objective: To evaluate the role of fine-needle aspiration cytology in the diagnosis of human immunodeficiency virus (HIV)-associated lymphadenopathy.Design: Case series.Setting: Tertiary care teaching hospital, India.Patients: Fifty consecutive HIV-positive patients, who presented with lymphadenopathy at the outpatient department and antiretroviral therapy clinic.Results: Tubercular lymphadenitis was the most common diagnosis, reported in 74% (n=37) of patients; 97.2% of them were acid-fast bacillipositive. Reactive lymphadenitis and fungal lymphadenitis were present in 10 and 1 cases, respectively. The most common cytomorphological pattern of tubercular lymphadenitis was necrotising suppurative lymphadenitis, present in 43.2% (n=16) of patients. Of eight biopsies done in reactive cases, six turned out to be tubercular lymphadenitis. Fineneedle aspiration cytology had a sensitivity of 83.7% for diagnosing tubercular lymphadenitis.Role of fine-needle aspiration cytology in human immunodeficiency virus-associated lymphadenopathy: a cross-sectional study from northern India

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“…Satyanarayana et al [20] in their study reported a reactive cytomorphological pattern in 16.4% of their cases of tuberculosis. Bottles et al [21] in their study on HIV lymphadenopathy mentioned that 50% aspirate showed reactive lymphoid hyperplasia, Picerno I et al [22] and Reid et al [10] found reactive hyperplasia in 41% and 51% aspirates respectively.…”

Section: Discussionmentioning

confidence: 97%

“…The literature available is mostly of the western world. [9,10] In Indian setting there is a different clinical presentation, clinical progress of the disease and the nature of the opportunistic infections in HIV positive and AIDS patients.…”

Section: Introductionmentioning

confidence: 99%

Fnac of Hiv Lymphadenopathy in a Tertiary Care Hospital: A Two Year Study

Surase¹,

Deka²,

Solanke³

et al. 2016

jemds

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The incidence of Human Immunodeficiency Virus (HIV) infection is seen to be increasing in Asia, particularly in the Indian subcontinent. Immune system and the central nervous system are the two major targets of this infection. HIV infection is often associated with a number of opportunistic infections and malignancies, presenting with lymphadenopathy which is one of the earliest manifestations of HIV infection. Hence, this study was done to evaluate the diagnostic utility of Fine Needle Aspiration Cytology (FNAC) for HIV positive lymphadenopathy patients and to analyse the different cytological diagnostic patterns of lymph node lesions in HIV/AIDS patients. MATERIALS AND METHODSA total of 70 cases were studied in this prospective study. Fine needle aspiration was done. Both alcohol fixed and air dried smears were prepared. Lymph node aspirates were stained with Haematoxylin and Eosin (H&E), Papanicolaou's stain (PAP), Giemsa and Ziehl and Neelsen (ZN) stain. All these stains were done in all the cases irrespective of the cytological findings. RESULTS AND DISCUSSIONIn the present study, out of 70 HIV positive patients, 40 (57.14%) were males and 30 (42.86%) were females with a male-tofemale ratio of 1.3:1. Maximum affected patients were seen in the age group of 31-40 years. The most common site of HIV lymphadenopathy is the cervical lymph nodes 47 (67.14%), followed by axillary 08 (11.44%), inguinal, submandibular and supraclavicular 04 (5.71%) cases each. The most common presentation was tuberculous lymphadenitis constituted about 42 (60%) cases. CONCLUSIONFNAC is reliable and inexpensive technique for evaluation and identification of opportunistic infections, neoplastic lesions and non-neoplastic lesions. In HIV patients, it helps in segregating cases which requires further evaluation. This is a quick and repeatable procedure which spare patients from lymph node excision and enable immediate treatment of specific infection.

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Diagnostic utility of fine needle aspiration (FNA) cytology in HIV‐infected patients with lymphadenopathy

Cited by 51 publications

References 38 publications

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Role of fine-needle aspiration cytology in human immunodeficiency virus-associated lymphadenopathy: a cross-sectional study from northern India

Fnac of Hiv Lymphadenopathy in a Tertiary Care Hospital: A Two Year Study

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