Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Muyanja, David; Kalyesubula, Robert; Namukwaya, Elizabeth; Othieno, Emmanuel; Mayanja‐Kizza, Harriet

doi:10.4314/ahs.v15i1.15

Cited by 24 publications

(18 citation statements)

References 22 publications

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“…[8][9][10][11] In a study of HIV infected patients, FNAC predicted the histological findings in 65 out of 73 cases (89%) and missed 7 cases (9.5%), with a sensitivity of 93.1%, specificity of 100%, positive predictive value of 100% and negative predictive value of 78.7% for tuberculosis. 12 In the present study, sensitivity of FNAC in diagnosing granulomatous diseases, lymphoid neoplasm and metastatic malignancies were found to be between 45-88%, after exclusion of non-representative and inadequate FNACs. The sensitivity of diagnosis of granulomatous disease in FNAC was only 45.83%, which increases to 70.03% if necrosis is accepted as a surrogate marker of granulomatous disease.…”

Section: Discussionmentioning

confidence: 92%

Study of diagnostic accuracy of fine needle aspiration cytology of lymph nodes over 6 years in a tertiary care hospital

Barui

Ganguli

Sanyal³

et al. 2017

Int J Res Med Sci

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Background: Lymph node fine needle aspiration cytology (FNAC) is the first line investigation for evaluation of lymph node disease. Existing literature reports high degree of correlation between lymph node FNAC and histological examination. The aim of the present study is to re-evaluate the diagnostic accuracy of FNAC in view of frequent discordance between FNAC and diagnosis on biopsy.Methods: Among a total of 495 lymph node FNACs and 291 biopsies, 69 adequate FNACs which were followed up with biopsy were evaluated with standard statistical methods for assessment of diagnostic accuracy.Results: The commonest diagnosis on biopsy was reactive lymph node (34.71%) followed by granulomatous disease (26.12%) and lymphoid neoplasms (20.96%). Reactive lymphadenitis and granulomatous disease were also the two commonest categories on FNAC (34.34% and 24.85% respectively). However, the sensitivity of FNAC in diagnosis of granulomatous disease was found to be 45.83%, which increases to 70.03% if necrosis is included as a marker of granulomatous disease. The greatest sensitivity was achieved in diagnosis of metastatic disease (88.89%), followed by lymphoid neoplasms (69.23%).Conclusions: FNAC is a useful tool for excluding specific categories of lymph node diseases, esp. metastatic disease. However, the technique needs improvement as to sample more representative areas of the node, to improve its sensitivity.

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Section: Discussionmentioning

confidence: 92%

Study of diagnostic accuracy of fine needle aspiration cytology of lymph nodes over 6 years in a tertiary care hospital

Barui

Ganguli

Sanyal³

et al. 2017

Int J Res Med Sci

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“…We found the accuracy of FNAC for TL to be good, with a sensitivity of 96.77% (97.44%) and a specificity of 100%. In the literature, the specificity and sensitivity of FNAC in the diagnosis of TL vary widely, from 43 to 100% [6,22,23]. This may be explained by the differences from 1 series to another in the criteria established for TL diagnosis: granuloma with caseation necrosis versus only granuloma or caseation necrosis.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis

et al. 2018

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Objective: This study assesses the role of fine-needle aspiration cytology (FNAC) in the diagnosis of tuberculous lymphadenitis (TL) in comparison with histology and bacteriology findings. Study Design: We undertook a descriptive retrospective study of 937 FNAC specimens from 851 patients with cervical lymph nodes. The FNAC findings were then compared to histopathology and bacteriology. Results: Of the 937 aspirates, the cytopathological diagnoses consisted of 426 (55.9%) TL, 185 (24.3%) reactive lymphoid hyperplasia, 18 (2.3%) suppurative inflammation, 78 (10.2%) malignant metastatic tumor, and 54 (7%) lymphoma. Of the 426 TL cases, 171 were diagnosed by FNAC combined with bacteriological examination. In this group, 22 cases were found to be positive on Ziehl-Neelsen stain and 16 by culture. A histopathology report was available for 62 cases. Compared to histopathology, the overall diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of FNAC in the diagnosis of cervical TL were, respectively, 96.77, 100, 100, and 96.67%. When comparing bacteriology to histopathology, these values were 97.44, 100, 100, and 91.67%. Conclusion: Our study shows that FNAC is a sensitive and specific tool for the diagnosis of cervical TL.

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“…FNAC is definitively useful tool in establishing diagnosis of tubercular lymphadenitis [13]. It is minimally invasive, faster and cheaper when compared to excision biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…It is minimally invasive, faster and cheaper when compared to excision biopsy. FNAC has a high diagnostic accuracy in detecting tuberculosis with sensitivity of 93.1% and specificity of 100% [13]. Cytological criteria include clusters of epitheloid cells with or without necrotic debris, mature lymphocytes and pleomorphic lymphoid cells [14], [15].…”

Section: Discussionmentioning

confidence: 99%

Pretracheal tuberculous abcess mimicking a thyroid swelling—A case report

Reddy

Daggolu

2016

International Journal of Surgery Case Reports

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HighlightsTuberculous cervical lymphadenitis is the most common extra pulmonary manifestation (Das et al., 2016 [1], Sharma and Mohan, 2004), posterior group of cervical nodes (Baskota et al., 2004 [2]) being the most common.Pre tracheal lymph node involvement in the neck is very rare.A high degree of suspicion for tuberculosis is needed while diagnosing a lower midline swelling in the anterior neck, especially in TB- endemic areas.Tuberculous abscess can be easily treated with incision and drainage along with anti tuberculous drugs, thus avoiding major surgery.

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Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Cited by 24 publications

References 22 publications

Study of diagnostic accuracy of fine needle aspiration cytology of lymph nodes over 6 years in a tertiary care hospital

Study of diagnostic accuracy of fine needle aspiration cytology of lymph nodes over 6 years in a tertiary care hospital

Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis

Pretracheal tuberculous abcess mimicking a thyroid swelling—A case report

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