Diagnostic ultrasound exposure during pregnancy potentially affects rabbit fetal parathyroid hormone level

Dom, Sulaiman Md; Razak, Hairil Rashmizal Abdul

doi:10.1109/chuser.2012.6504292

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…In the study by Ang et al (12), the authors found that the distribution of neurons of the cerebral neocortex in newborn mice differed significantly from control mice on the 10th day after birth when exposed to ultrasound wave for a total of 30 min or longer during the period of neuronal migration. Md Dom et al (13) suggested that parathyroid hormone (PTH) levels in rabbit fetal bodies exposed to ultrasound at different gestational stages were significantly decreased. A study on human chorionic villi indicated that the cleavage products of active caspase-3 and cytochrome c release were significantly increased in a time-dependent manner when exposed to transvaginal ultrasound in the first trimester of pregnancy (14).…”

Section: Discussionmentioning

confidence: 99%

Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi

Liu

Hou

Liang

et al. 2013

International Journal of Molecular Medicine

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Abstract. The aim of this study was to investigate the effects of diagnostic ultrasound on chorionic villi during early pregnancy in rats through the examination of heat shock protein 70 (HSP70) expression and apoptosis in chorionic villi. Using TUNEL, RT-PCR, western blot analysis and immunohistochemistry, the extent of apoptosis and the gene/ protein expression of HSP70, Bcl-2 and Bax was determined in the samples of the chorionic villus from the rats during early pregnancy. Compared with the unexposed group, there were clear signs that apoptosis had occurred in the villi exposed to ultrasound for 30 min. The expression of HSP70 and Bax in the villi gradually increased with the extended duration of exposure to ultrasound, whereas the expression of Bcl-2 gradually decreased. Bcl-2 expression did not differ significantly between the group exposed for 10 min and the group exposed for 20 min. Taken together, our data demonstrate that HSP70 may protect chorionic villi exposed to ultrasound by inhibiting apoptosis; however, its protective effects are limited over the extended duration of exposure to ultrasound. Thus, the prudent use of ultrasound during the early stages of pregnancy should be advocated.

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Section: Discussionmentioning

confidence: 99%

Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi

Liu

Hou

Liang

et al. 2013

International Journal of Molecular Medicine

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“…The results of the hormonal assay of total triiodothyronine (tT3) and total thyroxine (tT4) showed a numerical reduction but not statistically significant in the insonated group as compared to the non-insonated; ultrasound heating may have some effect on thyroid hormonal level. Dom et al (2013) reported a significantly lowered parathyroid hormone level in the insonated group as against the noninsonated. This could possibly be because there was an increase in the time of exposure (60minutes) as against the time of exposure in this study (5 minutes).…”

Section: Discussionmentioning

confidence: 93%

“…In fetal physiological development, formation of thyroid glands begins at the middle till the end stage of gestation (Terranova, 2009). Hence, any external disruption like ultrasound heating could possibly affect the development of the glands, thus its secretion (Dom et al, 2013). There are two basic mechanisms, thermal and non-thermal, by which ultrasound is known to affect biologic materials (Ndumbe et al, 2008;Sheiner & Abramowicz 2008;Brendt, 1986;Sikov, 1986a;Sikov, 1986b;Laurel, 1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of multiple in-utero insonation on rabbit fetal thyroid hormonal level

Idris¹,

Audu²,

Fadason³

et al. 2017

Sokoto J. Vet. Sc.

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Due to the increased use of ultrasound in the diagnosis of cyesis, it is necessary to study the possible adverse effect of insonation on thyroid hormone in fetuses. Sixteen (16) adult rabbit does that had kindled at least once were used for the study and were scanned using a Medison S600V ® Ultrasound machine with a 6.5MHz transcutaneous curve-linear probe. All does were mated naturally by the introduction of a doe to a buck and then divided randomly into two groups. The does that were scanned (insonated)-, were properly restrained on dorsal recumbency, liberally shaved; aquasonic gel applied and scanned using a transcutaneous curve-linear probe for 5 minutes on the 5 th day post coitus and thereafter on days 7, 12, 15, 20, 25, 27 and 29. The restrain and scanning procedures were mimicked on the group of does that were not scanned (non-insonated). Upon parturition, blood was collected from kits and serum was extracted and used to assay for total thyroxine (tT4) and triiodothyronine (tT3). Fetal thyroid glands were also harvested for histologic study. Mean tT3 concentration was 1.60 ± 0.90 µg/dl and 1.58 ± 0.03 µg/dl while mean tT4 was 1.46 ± 0.10 µg/dl and 1.39 ± 0.07 µg/dl for the non-insonated and insonated groups, respectively. P values of 0.610 and 0.132 for tT3 and tT4 concentration respectively showed that there is no statistically significant difference in the values even though there was a numerical difference between the groups. No histopathologic change on fetal thyroid gland from both groups was observed. In conclusion, although the values were not significantly different, the numerical decrease of both tT3 and tT4 in the insonated rabbits suggest the possibility that insonation could alter their values in fetuses when the threshold of ultrasound waves are increased and insonation prolonged.

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“…This might be due to a placentation disorder resulting from suboptimal nutrients transferred to a fetus [28]. In another in vivo study by Dom et al [30] the differences in fetal parathyroid hormone level in ultrasound exposed and non-ultrasound exposed group could lead to a possible result in alteration of physiological developments of fetus. This will cause various physiological variables alteration, not limited to reduction in fetal weight which was reveled in this study.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Prenatal Ultrasound Heating Throughout Gestation on Rabbit Fetal Weight

Zaiki

Dom

2014

IJBSBT

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The aim of this in vivo experimental study is to determine the association between ultrasound exposure time and rabbit fetal weight. A total of 14 pregnant does were exposed to ultrasound heating for 30, 60, and 90 minutes of ultrasound exposure at their middle of each gestational stage, while another 4 pregnant does served as control. Total of 136 fetuses (1 st stage, n=34 (25%); 2 nd stage, n=28 (20.6%); 3 rd stage, n=74 (54.4%)) were analyzed for fetal body weight. There were significant differences in fetal weight at all stages (p<0.05; 95% CI do not cross 0) of all groups at different length of exposure time. There were also negative correlation between groups with different exposure durations and fetal weight in the 1 st and the 3 rd stage (p<0.05; r =-0.40, p<0.05; r =-0.23 respectively). Exposure time was found poorly associated with fetal weight in the 1 st and the 3 rd stage (p<0.05; r 2 = 0.15 and 0.04 respectively). This study suggests the heating effect of ultrasound exposure might act as a noxious agent that promotes intrauterine growth restriction in developing fetus that might consequently impacts the rabbit fetal weight. Therefore a considerably increase in awareness of negligible effects aroused from prenatal ultrasound exposure was concerned as it was widely applied to pregnant women.

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Diagnostic ultrasound exposure during pregnancy potentially affects rabbit fetal parathyroid hormone level

Cited by 6 publications

References 9 publications

Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi

Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi

Effect of multiple in-utero insonation on rabbit fetal thyroid hormonal level

The Effect of Prenatal Ultrasound Heating Throughout Gestation on Rabbit Fetal Weight

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