Diagnostic Tests in Pancreatic Disease

Hanscom, Donald H.

doi:10.1016/s0025-7125(16)32841-3

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…The absorption of triolein is impaired and that of oleic acid is normal in pancreatic disease, whereas the absorptions of both are impaired in disease of the small bowel (11). This test has been criticized because of uncertainty regarding the stability of these compounds in the stomach, and the reliability of the procedure only in the presence of gross steatorrhea (12).…”

Section: Laboratory Findingsmentioning

confidence: 99%

Pancreatic Exocrine Insufficiency: Diagnosis and Medical Management*

Brown

1969

J American Geriatrics Society

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Pancreatic exocrine insufficiency is discussed from the viewpoints of physiology, etiology, signs and symptoms, laboratory findings, and treatment. Characteristic manifestations are those of malabsorption, with steatorrhea. The pancreatic secretin test is still the most valuable laboratory tool, though quantitative determination of fecal chymotrypsin may ultimately prove to be more advantageous. Pancrelipase or various other combinations of digestive enzymes often provide effective therapy.

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Section: Laboratory Findingsmentioning

confidence: 99%

Pancreatic Exocrine Insufficiency: Diagnosis and Medical Management*

Brown

1969

J American Geriatrics Society

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Secretin and Cholecystokinin

Mutt¹

1988

Advances in Metabolic Disorders

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A simple isotopic assay method for human serum phospholipase A₂activity

Mäkelä

Kuusi

Somerharju

et al. 1987

Scandinavian Journal of Clinical and Laboratory Investigation

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An assay using 2-(1-14C)palmitoyl-labelled dipalmitoyl phosphatidylcholine substrate for the determination of serum phospholipase A2 (PLA2) activity is described and validated. The rapid determination of the enzyme activity is enabled by a simple liquid-liquid partition system to replace the laborious thin-layer chromatography used in earlier studies. The PLA2 activity of human pancreatic juice was used for the optimization of the assay. Interference by serum phospholipids can be avoided by using 10 microliter aliquots of serum in the assay, whereas larger amounts caused a progressive inhibition of the enzyme activity. Virtually no enzyme activity is determined in serum from normal healthy subjects (range from 1.2 to 3.0 IU/l). In acute haemorrhagic pancreatitis the PLA2 activity is markedly elevated (range from 10.7 to 42.0 IU/l). Due to the simple extraction of the reaction products the results can be obtained the same day. Therefore, the assay can conveniently be used for the rapid clinical identification of subjects with acute haemorrhagic pancreatitis.

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Diagnostic Tests in Pancreatic Disease

Cited by 4 publications

References 10 publications

Pancreatic Exocrine Insufficiency: Diagnosis and Medical Management*

Pancreatic Exocrine Insufficiency: Diagnosis and Medical Management*

Secretin and Cholecystokinin

A simple isotopic assay method for human serum phospholipase A₂activity

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Diagnostic Tests in Pancreatic Disease

Cited by 4 publications

References 10 publications

Pancreatic Exocrine Insufficiency: Diagnosis and Medical Management*

Pancreatic Exocrine Insufficiency: Diagnosis and Medical Management*

Secretin and Cholecystokinin

A simple isotopic assay method for human serum phospholipase A2activity

Contact Info

Product

Resources

About

A simple isotopic assay method for human serum phospholipase A₂activity