Diagnostic strategies for subclinical hypothyroidism

Mohanty, Shruti; Amruthlal, W.; Reddy, G. C.; Kusumanjali, G.; Kanagasabapathy, A. S.; Rao, Pragna

doi:10.1007/s12291-008-0062-y

Cited by 20 publications

(26 citation statements)

References 13 publications

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“…This finding is similar with the study done by Canaris et al [15], which mentioned that autoimmune thyroid diseases affect women 2 to 4 times more than men. In addition, Mohanty et al [16] showed that 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO (73.78%), this finding also be in accord with our study. In agreement with our study Swain et al has also reported that most (95%) of the patients with autoimmune thyroid disease were women, mainly belonging to the age group of 30-50 years [2].…”

Section: Discussion:-supporting

confidence: 93%

Correlation of Anti-Thyroid Peroxidase Antibodies (Anti-Tpo) With Thyroid Hormones in Local Population of Western Nepal.

Dhakal¹,

Nagila²,

Koirala³

et al. 2017

IJAR

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Section: Discussion:-supporting

confidence: 93%

Correlation of Anti-Thyroid Peroxidase Antibodies (Anti-Tpo) With Thyroid Hormones in Local Population of Western Nepal.

Dhakal¹,

Nagila²,

Koirala³

et al. 2017

IJAR

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“…The worldwide prevalence of subclinical hypothyroidism ranges from 1 to 10% [18,19]. Since these patients develop overt hypothyroidism at the rate of 5% per year [19,20], it is important to identify these patients [21]. Typical biochemical picture suggestive of hypothyroidism was observed in 1.6% of samples.…”

Section: Resultsmentioning

confidence: 99%

Are we using Thyroid Function Tests Appropriately?

et al. 2011

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Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples (87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests. 77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7% in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction and order the appropriate test in a rational and cost effective manner.

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“…Similarly, Mohanty et al have showed that 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO (73.78%), thereby suggesting an autoimmune aetiology for subclinical thyroid dysfunction and a higher risk of developing overt hypothyroidism in such patients. 4 Bjoro et al in a 20-year follow-up study, conducted among Norwegian inhabitants (94,009), have found that the positive anti-TPO levels correlated significantly with thyroid dysfunction and the prevalence of elevated TSH was nearly 10-fold higher in both females and males with positive anti-TPO when compared to anti-TPO-negative subjects. 6 The study by Silva et al, conducted in 89 Brazilian women, has noted elevated anti-TPO levels in around 90% of the patients with autoimmune thyroiditis.…”

Section: Discussionmentioning

confidence: 98%

“…3 Another Indian study by Mohanty et al, has reported that among the 38 frank hypothyroid patients, 76% had raised anti-TPO levels. 4 In a crosssectional study conducted in Rajasthan, the prevalence of hypothyroidism noted in the overall study population (n=300) was 9.33%. A significantly higher number of females (83.33%) than males (16.67%) were diagnosed with subclinical hypothyroidism and a total of 56 (18.66%) subjects tested positive for anti-TPO antibody.…”

Section: Introductionmentioning

confidence: 97%

The prevalence of anti-thyroid peroxidase antibodies in subclinical and clinical hypothyroid patients

CA¹,

Avinash²,

Basappaji³

et al. 2015

Int J Res Med Sci

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INTRODUCTIONSubclinical hypothyroidism is a state of mild thyroid failure and is essentially a laboratory diagnosis with elevated serum thyroid stimulating hormone (TSH) and a normal free thyroxine (FT4) concentration.1 Subclinical hypothyroidism is much more common than overt hypothyroidism and hence the early diagnosis and treatment of the condition may prevent the onset of overt hypothyroidism and its associated effects.2 Patients with subclinical hypothyroidism with high titre of antithyroperoxidase (anti-TPO) antibodies are more likely to progress to overt hypothyroidism. Most of the hypothyroid patients have an elevated anti-TPO titre, suggesting an autoimmune etiology for hypothyroidism. Literature evidence substantiates the positive association between serum anti-TPO levels and the activity of chronic autoimmune thyroiditis. ABSTRACTBackground: Subclinical hypothyroidism is a state of mild thyroid failure and is essentially a laboratory diagnosis with elevated serum thyroid stimulating hormone (TSH) and a normal free thyroxine (FT4) concentration. The main objective of study is to evaluate the prevalence of anti-thyroid peroxidise (anti-TPO) antibodies among patients with clinical and subclinical hypothyroidism. Methods: A prospective study was conducted involving 50 patients with biochemical evidence of hypothyroidism. Subclinical hypothyroidism was defined as thyroid stimulating hormone (TSH) >5.0 µIU/ml with normal FT4 and clinical hypothyroidism as free thyroxine (FT4) and high TSH. A detailed history, clinical examination, and investigations comprising of complete haemogram, fasting plasma glucose, fasting FT4, TSH, anti-TPO antibodies and lipid profile were done for all the patients. Results: Out of 50 cases, 28 subjects had clinical hypothyroidism (25 females and 3 males) and 22 had subclinical hypothyroidism (14 females and 8males). Among the 50 subjects with clinical and subclinical hypothyroidism, 33 were anti-TPO positive. The corresponding percentage of anti-TPO positivity noted in the clinical hypothyroidism and subclinical hypothyroidism groups were 80 % and 50% respectively. Conclusions: Serum TSH and anti-TPO analyses are essential in determining the etiology of hypothyroidism and risk of progression to overt hypothyroidism in patients with subclinical.

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Diagnostic strategies for subclinical hypothyroidism

Abstract: ABSTRACT

Cited by 20 publications

References 13 publications

Correlation of Anti-Thyroid Peroxidase Antibodies (Anti-Tpo) With Thyroid Hormones in Local Population of Western Nepal.

Correlation of Anti-Thyroid Peroxidase Antibodies (Anti-Tpo) With Thyroid Hormones in Local Population of Western Nepal.

Are we using Thyroid Function Tests Appropriately?

The prevalence of anti-thyroid peroxidase antibodies in subclinical and clinical hypothyroid patients

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