Diagnostic signs of cutaneous lymphomas

Burg, Günter; Kempf, Werner; Dummer, Reinhard

doi:10.1046/j.0926-9959.2001.00265-2.x

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…In summary, our results support findings from other reports, that diagnostic assessment of cutaneous lymphoproliferative disorders is usually possible with integration of clinical, histopathologic, immunophenotypic and molecular biological findings [1,3,6,7,14]. Our observations emphasize importance of careful clinical follow-up and repeated skin biopsy in patients with unusual cutaneous lesions, such as mycosis fungoides-like therapy-resistant eczematous patches, small plaque parapsoriasis and actinic reticuloid, which dermatoses are considered as precursor of mycosis fungoides.…”

Section: Discussionsupporting

confidence: 91%

Clinical, Histopathological, Immunophenotypic and Molecular Analysis of 60 Patients with Cutaneous T-cell Infiltrates with Follow up of Indeterminate Cases to Identify T-cell Lymphoma

Erős

Károlyi

Marschalkó

et al. 2008

Pathol. Oncol. Res.

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Diagnosis of primary cutaneous T-cell lymphomas, especially of mycosis fungoides could be difficult in early stage due to clinical and histopathological similarity to reactive inflammatory dermatoses. To assess diagnostic value of complex histological, immunophenotypic and T-cell receptor gamma gene rearrangement analysis, skin biopsy specimen and peripheral blood samples of 60 patients with suspected cutaneous T-cell lymphoma were analyzed. Our results indicate clear distinction between reactive dermatoses (benign cases, n = 31) and cutaneous T-cell lymphomas (lymphoma cases, n = 17). As definite diagnosis was not obtained in a smaller group of patients (indeterminate cases, n = 12), these patients were followed up. Repeated skin biopsy confirmed mycosis fungoides in 6/12 cases, however in 6/12 patients the diagnosis remained indeterminate. We concluded that careful and complex clinical follow up and repeated histopathological, immunophenotypic and molecular analysis is needed for an appropriate diagnosis in the assessment of early stage mycosis fungoides and uncertain clinical cases.

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Section: Discussionsupporting

confidence: 91%

Clinical, Histopathological, Immunophenotypic and Molecular Analysis of 60 Patients with Cutaneous T-cell Infiltrates with Follow up of Indeterminate Cases to Identify T-cell Lymphoma

Erős

Károlyi

Marschalkó

et al. 2008

Pathol. Oncol. Res.

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“…Therefore, if lymphoma is suspected then the diagnosis must be confirmed by clinical, histological and molecular examinations perhaps repeated in the course of the disease. In about 10% of cases the diagnosis can only be confirmed during the course of disease 4 . Whole‐body inspection often allows identification of typical lesions besides atypical lesions, thus guiding towards the correct diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…Detection of a monoclonal T‐cell infiltrate is not lymphoma specific. Positive polymerase chain reaction (PCR) results are also found in diseases such as psoriasis, pityriasis lichenoides et varioliformis acuta (PLEVA) and lichen ruber 3,4 . Thus clinical presentation is a major factor determining the diagnosis 5 …”

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confidence: 99%

Mycosis fungoides: a dermatological masquerader

et al. 2007

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Mycosis fungoides (MF), a low-grade lymphoproliferative disorder, is the most common type of cutaneous T-cell lymphoma. Typically, neoplastic T cells localize to the skin and produce patches, plaques, tumours or erythroderma. Diagnosis of MF can be difficult due to highly variable presentations and the sometimes nonspecific nature of histological findings. Molecular biology has improved the diagnostic accuracy. Nevertheless, clinical experience is of substantial importance as MF can resemble a wide variety of skin diseases. We performed a literature review and found that MF can mimic >50 different clinical entities. We present a structured framework of clinical variations of classical, unusual and distinct forms of MF. Distinct subforms such as ichthyotic MF, adnexotropic (including syringotropic and folliculotropic) MF, MF with follicular mucinosis, granulomatous MF with granulomatous slack skin and papuloerythroderma of Ofuji are delineated in more detail.

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“…The initial skin manifestations of GSS are violaceous indurated plaques with atrophy, which transform into bulky, excessive skin folds, which enlarge slowly over several years 1, 2, 3, 4, 23. In rare cases, erythematous patches with poikiloderma have been described.…”

Section: Discussionmentioning

confidence: 99%

“…Granulomatous slack skin (GSS), a rare variant of mycosis fungoides, is characterized clinically by bulky, pendulous skin folds on flexural areas and histologically by elastolytic granulomatous infiltrates of clonal T cells 1, 2, 3, 4, 5, 6, 7, 8, 9. The monoclonal rearrangement of the T-cell receptor β and γ genes can be demonstrated by polymerase chain reaction in most cases 6, 7, 10, 11…”

Section: Introductionmentioning

confidence: 99%