Clinical, Histopathological, Immunophenotypic and Molecular Analysis of 60 Patients with Cutaneous T-cell Infiltrates with Follow up of Indeterminate Cases to Identify T-cell Lymphoma

Erős, Nóra; Károlyi, Zsuzsánna; Marschalkó, Márta; Kárpáti, Sarolta; Matolcsy, András

doi:10.1007/s12253-008-9014-3

Cited by 3 publications

(2 citation statements)

References 19 publications

(15 reference statements)

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“…Six case reports were excluded as redundancy with later articles was suspected [88,89,90,91,92]. PEO patients cited only in research studies among other dermatoses were also excluded [93,94,95,96,97]. …”

Section: Resultsmentioning

confidence: 99%

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Torchia

Miteva

et al. 2010

Dermatology

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Background: Even after the description of papuloerythroderma of Ofuji (PEO) in 1984, little is known about this clinical entity. Objective:To report on 2 new cases of PEO and review of the worldwide literature on this topic. Methods: Article citations were searched on several biomedical search engines (PubMed, EMBASE, SCOPUS, Google Scholar). Papers were retrieved either online or in print. Results: A grand total of 170 PEO cases were identified. Most patients were older than 55 years and of Asian or white descent, with an overall male/female ratio of 4.0. Itch and the deck-chair sign were observed in all patients. Peripheral eosinophilia, lymphocytopenia and increased serum IgE were common findings. Histopathology mostly showed aspecific inflammation, while 17 showed histological features of cutaneous T-cell lymphoma (CTCL). Atopy, malignancies, infections and drugs were rarely linked to PEO. Conclusion: PEO represents a rather monomorphous entity both clinically and, with the remarkable exception of CTCL, also histologically. Nonetheless, no causative factor could be identified in the vast majority of cases. An etiological classification and diagnostic criteria are proposed in the attempt to contribute framing this puzzling clinical entity.

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Section: Resultsmentioning

confidence: 99%

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Torchia

Miteva

et al. 2010

Dermatology

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“…Therefore, the early diagnosis of MF must be based on pathologic changes, with immunohistochemistry and gene rearrangement analysis as important adjunct diagnostic tools. For some suspected cases with no clonal gene rearrangement, long-term follow-up and multiple pathologic examinations should be done to confirm the diagnosis[20].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic significance of TCR gene clonal rearrangement analysis in early mycosis fungoides

Wan²,

Wang³

et al. 2011

Chin J Cancer

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Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, has various unspecific clinical and histological characteristics. Its early diagnosis is challenging. The application of T-cell receptor (TCR) gene clonal rearrangement to the diagnosis of MF has been widely studied. In this study, we used polymerase chain reaction (PCR) to investigate the diagnostic significance of detecting TCR-γ and -β gene clonal rearrangement in the early diagnosis of mycosis fungoides. PCR for TCR-γ and TCR-β gene rearrangement was performed on 19 patients with suspected early MF, 6 with typical MF, and 6 with chronic dermatitis. Of the 19 patients with suspected early MF, 13 had TCR-γ gene clonal rearrangement, whereas none had TCR-β gene clonal rearrangement. All patients with typical MF had TCR gene clonal rearrangement, in which 4 showed TCR-γ clonal rearrangement, 1 showed TCR-β gene clonal rearrangements, and 1 showed both. No patients with chronic dermatitis had TCR gene clonal rearrangement. These results indicate that TCR gene clonal rearrangement analysis is a useful tool in diagnosing early MF. TCR-γ gene is recommended to the routine analysis, whereas TCR-β gene has potential in combination toward intractable cases.

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The role of immunohistochemical analysis in the diagnosis of parapsoriasis

et al. 2011

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Clinical, Histopathological, Immunophenotypic and Molecular Analysis of 60 Patients with Cutaneous T-cell Infiltrates with Follow up of Indeterminate Cases to Identify T-cell Lymphoma

Cited by 3 publications

References 19 publications

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Papuloerythroderma 2009: Two New Cases and Systematic Review of the Worldwide Literature 25 Years after Its Identification by Ofuji et al.

Diagnostic significance of TCR gene clonal rearrangement analysis in early mycosis fungoides

The role of immunohistochemical analysis in the diagnosis of parapsoriasis

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