Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma

Comparison osteopontin vs AFP for the diagnosis of HCC: A meta-analysis

“…Finally, 7 studies dealing with the performance of OPN for the diagnosis of HCC were included in the present meta-analysis ( Fig. 1) [19][20][21][22][23][24][25]. The characteristics of each included study are shown in Table 1.…”

“…Therefore, a number of novel candidate markers have been suggested to change the present situation. OPN is one of attractive potential tumor markers, because it exists not only as an immobilized extracellular matrix molecule, but also in a secreted form in body fluids including plasma [21].…”

Single-nucleotide polymorphism in the promoter region of the osteopontin gene at nucleotide −443 as a marker predicting the efficacy of pegylated interferon/ribavirin-therapy in Egyptians patients with chronic hepatitis C

“…OPN was previously found to be associated with hepatitis activity and fibrosis grade [28,29]. Heilmann et al [30] reported that OPN had a dual function on inflammation regulation.…”

Role of Osteopontin in Liver Diseases

“…OPN has good sensitivity in AFP-negative HCC, indicating OPN as a better marker in the early stage of HCC 13. OPN expression significantly correlates with clinicopathological features of HCC patients with HBV and/or HCV such as capsular infiltration, vascular invasion, lymph node metastasis and TNM stages 71, 72. A study of Korean HBV-related cirrhosis and HCC has showed that genetic polymorphisms in the OPN gene are associated with HBV clearance and the age of HCC occurrence 73.…”