Comparison osteopontin vs AFP for the diagnosis of HCC: A meta-analysis

Wan, Haoguang; Xu, Hao; Gu, Yuming; Wang, Hui; Xu, Wei; Zu, Maoheng

doi:10.1016/j.clinre.2014.06.008

Cited by 69 publications

(55 citation statements)

References 27 publications

(30 reference statements)

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“…When compared with cirrhosis, CHC, chronic hepatitis B or healthy controls, OPN plasma levels were significantly elevated in HCC patients [54] . At a serum of 557 ng/mL, OPN has sensitivity, specificity and AUC of 26%, 92.5% and 51%, respectively, for the diagnosis of HCC [55,56] . of 0.749 [60] .…”

Section: Osteopontinmentioning

confidence: 99%

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Khattab

Fouad

Ahmed

2015

WJH

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The prevalence of hepatocellular carcinoma (HCC) has progressively increased in recent years and is now the fifth and the second most common cancer in the World and in Egypt, respectively. Much work has focused in the development of assays for detecting hepatic carcinogensis before the observance of hepatic focal lesions. Particular attention has been directed towards HCC-specific biomarkers for use in the early diagnosis of HCC and in the confirmation of radiological studies. Although a number of biomarkers have been identified, none have been considered reliable indicators of early HCC lesions. This review presents a few of the most relevant HCC biomarkers and suggests improvements to the accuracy of diagnostic assays through their combined use. Furthermore, we present an algorithm for the biomarker-based diagnosis of HCC and highlight its important role in the early prediction of HCC. Core tip: Alpha-fetoprotein (AFP) has been widely used as a reference biomarker to validate the diagnosis of hepatocellular carcinoma (HCC). However, normal physiological-levels of AFP are observed in approximately one third of HCC cases. Furthermore, a number of HCC positive patients have AFP levels less than the threshold value of 400 ng/mL. These factors make an AFP-based diagnosis of HCC far from reliable. However, high diagnostic accuracy indices have been reported when AFP is combined with other biomarkers such as midkine, golgi protein 73, des-γ-carboxyprothrombin, glypican-3, and gamma-glutamyl transferase.Khattab M, Fouad M, Ahmed E. Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma. World J Hepatol 2015; 7(23): 24742481 Available from:

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Section: Osteopontinmentioning

confidence: 99%

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Khattab

Fouad

Ahmed

2015

WJH

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“…that OPN expression was inversely correlated with prognosis in AML patients (11,12,14). Whereas the majority of the publications had focused on solid tumors (18)(19)(20)(21), there have been recent studies on the role of OPN in hematological malignancies (10,12). Increased serum OPN concentrations have been reported in chronic myeloid leukemia, multiple myeloma and AML (22).…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Chen

Ren

et al. 2017

mol clin onc

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Abstract. Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN overexpression in acute myeloid leukemia (AML) remains controversial. A meta-analysis of four studies, including a total of 492 patients, was performed to determine the association of OPN with overall survival (OS) in AML patients. The random-effects model of Der Simonian and Laird was used to synthesize data; hazard ratio (HR) with its 95% confidence interval (CI) was used as the effect size estimate. It was observed that serum-based OPN was inversely correlated with OS and the difference was statistically significant (HR=1.83; 95% CI: 1.43-2.35; P<0.001). Experimental findings indicate that OPN overexpression is associated with a poor prognosis in AML and may be of prognostic value for AML stage and metastasis.

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“…At present, AFP is the most effective diagnostic indicator for HCC (36). A recent meta-analysis of the diagnostic value of AFP in HCC determined a pooled sensitivity of 66%, a specificity of 86% and an AUC value of 0.87 (37). The combination of AFP with DCP produced a sensitivity of 55% for the detection of early-stage HCC and 78% for the diagnosis of all stages of HCC, with cut-off values of 10 ng/ml for AFP and 5 ng/ml for DCP (38).…”

Section: Discussionmentioning

confidence: 99%

Serum levels of anti‑sperm‑associated antigen 9 antibody are elevated in patients with hepatocellular carcinoma

Ren

Zou

et al. 2017

Oncol Lett

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Abstract. At present, there is a high incidence of viral hepatitis and high mortality rates due to hepatocellular carcinoma (HCC) in China. In the current study, the quantification of antibodies against the cancer-testis antigen sperm-associated antigen 9 (SPAG9), alone and combined with α-fetoprotein (AFP), were evaluated as biomarkers for the diagnosis of HCC. The levels of anti-SPAG9 antibody and AFP were quantified in serum samples from patients with HCC and hepatitis or cirrhosis, as well as healthy volunteers. The results revealed that the serum levels of anti-SPAG9 immunoglobulin G antibody in patients with HCC were significantly higher compared with those in patients with hepatitis/cirrhosis and healthy controls. Using receiver operator characteristic curves, the area under the curve (AUC, 0.870) of SPAG9 as a diagnostic marker of HCC was significant [P<0.001; 95% confidence interval (CI), 0.793-0.947], whereas the AUC of AFP was 0.832 (P<0.001; 95% CI, 0.736-0.928). Serum anti-SPAG9 antibody levels exhibited significant potential for the differential diagnosis of HCC, with an AUC value of 0.729, (P=0.008; 95% CI, 0.559-0.899). Similarly, serum AFP levels exhibited significant value for the differential diagnosis of HCC, with an AUC value of 0.842 (P<0.001; 95% CI, 0.732-0.953). When combined with quantification of AFP, the diagnostic sensitivity and specificity of anti-SPAG9 levels were increased. In summary, the results suggested that anti-SPAG9 antibody is a potential early diagnostic marker of HCC. IntroductionHepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major risk factors for the development of human hepatocellular carcinoma (HCC) (1-3). The incidence of HCC in China is ~100/100,000 population, and a principal component of the attributable risk is chronic HBV infection (4), with >50% of the global HCC burden attributed to HBV (5). In China, ~10% of patients with HCC suffer from HCV infection, and certain patients have HBV and HCV co-infections (6). In the USA, Europe and Japan, >50% of current cases of HCC are attributable to HCV infection, and the majority of these patients have cirrhosis (7-9). The time from initial diagnosis of chronic hepatitis to the development of HCC may span several decades; once cirrhosis is established, HCC develops at a yearly rate of 1-4% (10).In China, the majority of patients with HCC present with advanced-stage disease, and HCC has become the second leading cause of mortality (11). Early diagnosis relies on non-invasive biomarkers, imaging and clinical parameters, with markers such as α-fetoprotein (AFP), the proportion of the fucosylated isoform of AFP to total AFP, AFP-L3 and des-gamma-carboxy-prothrombin (DCP) being Food and Drug Administration-approved for use in the surveillance of high-risk populations (12,13). However, the clinical value of these biomarkers is a subject of debate (14). In Japan, three biomarkers are combined for surveillance (15,16), and this combined testing has a high level of sensitivity and specificity (17,18). In Ch...

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Comparison osteopontin vs AFP for the diagnosis of HCC: A meta-analysis

Cited by 69 publications

References 27 publications

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Serum levels of anti‑sperm‑associated antigen 9 antibody are elevated in patients with hepatocellular carcinoma

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