Diagnostic Significance of Cortical Superficial Siderosis for Alzheimer Disease in Patients with Cognitive Impairment

Inoue, Yuichi; Nakajima, Makoto; Uetani, Hiroyuki; Hirai, Toshinori; Ueda, Miki; Kitajima, Mika; Utsunomiya, Daisuke; Watanabe, Moe; Hashimoto, Mamoru; Ikeda, Manabu; Yamashita, Yoshimi; Ando, Yumiko

doi:10.3174/ajnr.a4496

Cited by 28 publications

(16 citation statements)

References 33 publications

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“…Previous data on cSS in large consecutive memory clinic series are relatively limited. Prevalence of cSS in memory clinic setting ranges from 2.1% to 6.1%, 5,13,14,25 in line with our prevalence of 3.0%, with a 0.7% prevalence in healthy populations. 26 cSS occurred in varying diagnoses throughout our series, with the highest prevalence observed in vascular dementia, followed by AD.…”

Section: Statistical Analysis Categorical Variables Were Analyzed Withsupporting

confidence: 89%

Cortical superficial siderosis

et al. 2016

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Section: Statistical Analysis Categorical Variables Were Analyzed Withsupporting

confidence: 89%

Cortical superficial siderosis

et al. 2016

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“…Fourteen studies (all published) met our predetermined criteria, however, five of these were from a same cohort, and other three were from cohorts of intracerebral hemorrhage (ICH) population. Finally, seven studies were pooled in a meta-analysis (Figure 1) (7–9, 12–15). Characteristics of the included studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…However, few studies investigated the relationship between cSS and dementia, and the results are controversial. Zonneveld et al found a higher prevalence of cSS in patients with AD than those with mild cognitive impairment (MCI) (8), whereas a recent study failed to demonstrate the diagnostic significance of cSS for AD (9). We thus performed a meta-analysis to determine whether associations between cSS and dementia or AD exist in patients with cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Association Between Cortical Superficial Siderosis and Dementia in Patients With Cognitive Impairment: A Meta-Analysis

et al. 2019

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Background: It remains unclear whether cortical superficial siderosis (cSS) is associated with dementia and its subtypes. We thus performed a meta-analysis to evaluate the relationship between dementia and cSS.Methods: We searched EMBASE, PubMed, and Web of Science for relevant studies assessing risk of dementia and prevalence of cSS in patients with cognitive impairment. Fixed-effects and random-effects models were performed.Results: Seven eligible studies including 3,218 patients with definite cognitive impairment were pooled in meta-analysis. The prevalence of cSS was 3.4%. The pooled analysis demonstrates odds ratio for cSS and dementia to be 1.60 (95% CI 1.04–2.44; p = 0.031). Subgroup analysis further indicated a significant association between cSS and Alzheimer's disease (AD) (OR = 2.01, 95% CI 1.34–3.02; p < 0.001), but not non-AD dementia (OR = 0.700, 95% CI 0.435–1.128; p = 0.143).Conclusions: Our meta-analysis of available published data demonstrates an increased prevalence of dementia in the subjects with pre-existing cSS, especially for AD. These findings suggest cSS to be a candidate imaging indicator for AD. Further longitudinal research is needed to investigate the clinical relevance.

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“…6,32,33 Second, concomitant presence of CMB and cSS points toward a common underlying cause, as has been shown in CAA 34 and AD. 35 However, other studies found that CMB and cSS do not necessarily occur simultaneously in CAA. 19,20 Third, progression of CMB and cSS over time, as shown in adult patients with CAA, 29 points towards a common neuropathological mechanism.…”

Section: Our Findings Might Indicate Early Caa In Dsmentioning

confidence: 95%