Association Between Cortical Superficial Siderosis and Dementia in Patients With Cognitive Impairment: A Meta-Analysis

Abstract

Background: It remains unclear whether cortical superficial siderosis (cSS) is associated with dementia and its subtypes. We thus performed a meta-analysis to evaluate the relationship between dementia and cSS.Methods: We searched EMBASE, PubMed, and Web of Science for relevant studies assessing risk of dementia and prevalence of cSS in patients with cognitive impairment. Fixed-effects and random-effects models were performed.Results: Seven eligible studies including 3,218 patients with definite cognitive impairment were pooled in meta-analysis. The prevalence of cSS was 3.4%. The pooled analysis demonstrates odds ratio for cSS and dementia to be 1.60 (95% CI 1.04–2.44; p = 0.031). Subgroup analysis further indicated a significant association between cSS and Alzheimer's disease (AD) (OR = 2.01, 95% CI 1.34–3.02; p < 0.001), but not non-AD dementia (OR = 0.700, 95% CI 0.435–1.128; p = 0.143).Conclusions: Our meta-analysis of available published data demonstrates an increased prevalence of dementia in the subjects with pre-existing cSS, especially for AD. These findings suggest cSS to be a candidate imaging indicator for AD. Further longitudinal research is needed to investigate the clinical relevance.

Cerebral tau pathology in cerebral amyloid angiopathy

“…The same findings were observed in a meta-analysis of subjects with cognitive impairment, in that there is an association between the presence of cSS and Alzheimer’s disease. 39 Currently, there is limited evidence from a mechanistic viewpoint to explain the relationship between cSS and cerebral tau accumulation. This observation could be suggestive of a possible relationship between leptomeningeal Aβ vasculopathy and cerebral tau pathologies, as cSS has been associated with a higher severity of CAA in the leptomeningeal vessels, but not in the cortical vessels.…”

Subcortical signal alteration of corticospinal tracts. A radiologic manifestation of ARIA: A case report

“…Although ARIA-E has been observed mostly during clinical trials of Aβ-lowering therapeutics [13 , 17 , [24] , [25] , [26] , [27] , [28] , [29] ], it may also develop spontaneously in AD patients, likely indicating the inflammatory phase of cerebral amyloid angiopathy [30] . Similarly, microhemorrhages and superficial siderosis spontaneously develop in cerebral amyloid angiopathy patients, regardless of anti-Aβ therapy [31 , 32] .…”

El impacto del entorno residencial en la adaptación psicosocial y calidad de vida de personas cuidadoras de familiares con demencia

“…La literatura científi ca se ha focalizado, no obstante, en la detección, diagnóstico y tratamiento médico de la enfermedad, en el cuidado sociosanitario de la persona con demencia y en el impacto de esta patología sobre la persona cuidadora. En cuanto al estudio de la demencia, se han analizado factores sanitarios como los determinantes biomédicos (Rentz et al, 2017;Akinori et al, 2019), el deterioro cognitivo (Bartolomé et al, 2010;Antelo y Espinosa, 2017;Chenheng et al, 2019) y los trastornos conductuales (Gómez-Romero et al, 2014;Kratz, 2017;Garzón y Pascual, 2018), entre otros. Del cuidado sociosanitario de las personas con demencia, ha interesado el diseño y aplicación de modelos de atención como el centrado en la persona OBETS.…”