Diagnostic significance of arterial spin labeling in the assessment of tumor grade in brain

Hou, Bo; Yang, Su-Jun; Zhang, Xiaorui; Dong, Xin; Zhang, Min; Yao, Gen-Dong

doi:10.4103/0973-1482.155978

Cited by 7 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested in the meta-analyses that the classification of brain tumors could be affected by ASL perfusion imaging using rCBF and rTBF values. 24,25 In the present study, we observed lower TBF, rTBF-M, and rTBF-WM values in LGG compared with HGG, which were in agreement with other researches, 13,23,26,27 indicating that ASL could be used for the classification of brain gliomas. Moreover, multiple comparisons demonstrated that there was a statistical difference between the TBF and rTBF-WM values between grade II and III gliomas, as well as grade I and IV gliomas.…”

Section: Discussionsupporting

confidence: 93%

“…It has been suggested in the meta‐analyses that the classification of brain tumors could be affected by ASL perfusion imaging using rCBF and rTBF values 24,25 . In the present study, we observed lower TBF, rTBF‐M, and rTBF‐WM values in LGG compared with HGG, which were in agreement with other researches, 13,23,26,27 indicating that ASL could be used for the classification of brain gliomas.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Efficacy of three‐dimensional arterial spin labeling and how it compares against that of contrast enhanced magnetic resonance imaging in preoperative grading of brain gliomas

Wang

Guo

Tian

et al. 2023

Environmental Toxicology

View full text Add to dashboard Cite

Purpose: To evaluate the efficacy of three-dimensional arterial spin labeling (3D-ASL) imaging in preoperative grading of brain gliomas, and compare the discrepancy between images obtained from 3D-ASL and contrast enhanced magnetic resonance imaging (CE-MRI) in grading of gliomas.Methods: Fifty-one patients with brain gliomas received plain MRI, CE-MRI and 3D-ASL scanning before surgery. In 3D-ASL images, the maximum tumor blood flow (TBF) of tumor parenchyma was measured, relative TBF-M and rTBF-WM were calculated. The cases were categorized into "ASL dominant" and "CE dominant" to compare the discrepancy between 3D-ASL and CE-MRI results. Independent samples t test, Mann-Whitney and U test and one-way analysis of variance (ANOVA) were performed to test the differences of TBF, rTBF-M and rTBF-WM values among brain gliomas with different grades. Spearman rank correlation analysis was performed to assess the correlation between TBF, rTBF-M, rTBF-WM and glioma grades respectively. To compare the discrepancy between 3D-ASL and CE-MRI results.Results: In high-grade gliomas (HGG) group, TBF, rTBF-M and rTBF-WM values were higher than those in low-grade gliomas (LGG) group (p < .05). Multiple comparison showed TBF and rTBF-WM values were different between grade I and IV gliomas, grade II and IV gliomas (both p < .05), the rTBF-M value was different between grade I and IV gliomas (p < .05). The values of all 3D-ASL derived parameters were positively correlated with gliomas grading (all p < .001). TBF showed highest specificity (89.3%) and rTBF-WM showed highest sensitivity (96.4%) when discriminating LGG and HGG using ROC curve. There were 29 CE dominant cases (23 cases were HGG), 9 ASL dominant cases (4 cases were HGG).Conclusion: 3D-ASL is of significance to preoperative grading of brain gliomas and might be more sensitive than CE-MRI in detection of tumor perfusion.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Efficacy of three‐dimensional arterial spin labeling and how it compares against that of contrast enhanced magnetic resonance imaging in preoperative grading of brain gliomas

Wang

Guo

Tian

et al. 2023

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…rCBV. This method is also currently the most common ASL method to quantify the perfusion in an area of interest, as described in a meta-analysis by Wang et al [ 18 ]. Not only the method of using ratios is similar, also the diagnostic accuracy is comparable.…”

Section: Discussionmentioning

confidence: 99%

Arterial spin labelling MRI for brain tumour surveillance: do we really need cerebral blood flow maps?

et al. 2023

View full text Add to dashboard Cite

Objectives Arterial spin labelling (ASL) perfusion MRI is one of the available advanced MRI techniques for brain tumour surveillance. The first aim of this study was to investigate the correlation between quantitative cerebral blood flow (CBF) and non-quantitative perfusion weighted imaging (ASL-PWI) measurements. The second aim was to investigate the diagnostic accuracy of ASL-CBF and ASL-PWI measurements as well as visual assessment for identifying tumour progression. Methods A consecutive cohort of patients who underwent 3-T MRI surveillance containing ASL for treated brain tumours was used. ROIs were drawn in representative parts of tumours in the ASL-CBF maps and copied to the ASL-PWI. ASL-CBF ratios and ASL-PWI ratios of the tumour ROI versus normal appearing white matter (NAWM) were correlated (Pearson correlation) and AUCs were calculated to assess diagnostic accuracy. Additionally, lesions were visually classified as hypointense, isointense, or hyperintense. We calculated accuracy at two thresholds: low threshold (between hypointense-isointense) and high threshold (between isointense-hyperintense). Results A total of 173 lesions, both enhancing and non-enhancing, measured in 115 patients (93 glioma, 16 metastasis, and 6 lymphoma) showed a very high correlation of 0.96 (95% CI: 0.88–0.99) between ASL-CBF ratios and ASL-PWI ratios. AUC was 0.76 (95%CI: 0.65–0.88) for ASL-CBF ratios and 0.72 (95%CI: 0.58–0.85) for ASL-PWI ratios. Diagnostic accuracy of visual assessment for enhancing lesions was 0.72. Conclusion ASL-PWI ratios and ASL-CBF ratios showed a high correlation and comparable AUCs; therefore, quantification of ASL-CBF could be omitted in these patients. Visual classification had comparable diagnostic accuracy to the ASL-PWI or ASL-CBF ratios. Clinical relevance statement This study shows that CBF quantification of ASL perfusion MRI could be omitted for brain tumour surveillance and that visual assessment provides the same diagnostic accuracy. This greatly reduces the complexity of the use of ASL in routine clinical practice. Key Points • Arterial spin labelling MRI for clinical brain tumour surveillance is undervalued and underinvestigated. • Non-quantitative and quantitative arterial spin labelling assessments show high correlation and comparable diagnostic accuracy. • Quantification of arterial spin labelling MRI could be omitted to improve daily clinical workflow.

show abstract

Advanced and amplified BOLD fluctuations in high‐grade gliomas

Gupta

Postma

et al. 2017

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

Diagnostic significance of arterial spin labeling in the assessment of tumor grade in brain

Abstract: These results showed that rTBF and rCBF were faster in high-grade brain cancer patients, suggesting that ASL may provide suitable measurement for the differential diagnosis of tumor grade in brain.

Cited by 7 publications

References 0 publications

Efficacy of three‐dimensional arterial spin labeling and how it compares against that of contrast enhanced magnetic resonance imaging in preoperative grading of brain gliomas

Efficacy of three‐dimensional arterial spin labeling and how it compares against that of contrast enhanced magnetic resonance imaging in preoperative grading of brain gliomas

Arterial spin labelling MRI for brain tumour surveillance: do we really need cerebral blood flow maps?

Advanced and amplified BOLD fluctuations in high‐grade gliomas

Contact Info

Product

Resources

About