Advanced and amplified BOLD fluctuations in high‐grade gliomas

Gupta, Lalit; Gupta, Rakesh K.; Postma, Alida A.; Sahoo, Prativa; Gupta, Pradeep Kumar; Patir, Rana; Ahlawat, Sunita; Saha, Indrajit; Backes, Walter H.

doi:10.1002/jmri.25869

Cited by 14 publications

(26 citation statements)

References 42 publications

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“…Phospholipid vesicles are used as model systems for a wide range of investigations, including vesicle permeation by amyloidogenic peptides, [10,46] changes in membrane dynamics upon protein binding [22] and the transport of ions and small molecules across a membrane [15,16]. The results presented here indicate that using phospholipid vesicles as a mimetic of membrane interaction care should be taken using paramagnetic shift reagents and freshly prepared vesicles that any changes in 31 P peak position or appearance over the early time points of an experiment is not simply a result of this "maturation" or reequilibration process, but arises from the action under investigation.…”

Section: Discussionmentioning

confidence: 99%

“…The use of other, often more dilute, NMR-active nuclei can alleviate this problem, depending on their location in or around the vesicle bilayer. For example, the functioning of ion channels, and their inhibition by various compounds such as toxins or anaesthetics has been investigated using 7 Li and 23 Na NMR and the use of paramagnetic shift reagents based on dysprosium (III) [15,16]. The lipids themselves, can be observed directly using the single phosphorus atom located in the head group of each molecule.…”

Section: Introductionmentioning

confidence: 99%

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Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles

Joyce

Williams

Serpell

et al. 2016

Chemical Physics Letters

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Phospholipid vesicles are commonly used as biomimetics in the investigation of the interaction of various species with cell membranes. In this paper we present a 31 P NMR investigation of a simple vesicle system using a paramagnetic shift reagent to probe the inner and outer layers of the lipid bilayer. Time-dependent changes in the 31 P NMR signal are observed, which differ whether the paramagnetic species is inside or outside the vesicle, and on the choice of buffer solution used. An interpretation of these results is given in terms of the interaction of the paramagnetic shift reagent with the lipids.3

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles

Joyce

Williams

Serpell

et al. 2016

Chemical Physics Letters

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“…Time‐shift analysis, a new method, has been proposed in previous studies where timing of tissue perfusion information could be obtained from rs‐fMRI, and has been used as a promising new approach not only to assess hemodynamics in acute or subacute stroke, and even in gliomas, as well as to demonstrate the extent and degree of perfusion delay in these patients . These previous studies found that temporal‐delayed resting state BOLD signal fluctuations have been shown to correlate with mean transit time in patients with acute stroke and time to peak in healthy subjects, suggesting that a major component of the low‐frequency oscillations arise from fluctuations in blood flow …”

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confidence: 99%

Detecting perfusion deficit in Alzheimer's disease and mild cognitive impairment patients by resting‐state fMRI

Yan

et al. 2018

Magnetic Resonance Imaging

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Background: Vascular factors contributing to cerebral hypoperfusion are implicated in the risk of developing Alzheimer's disease (AD). Purpose: To investigate the time-shift mapping created time-shift value of the brain by resting-state functional magnetic resonance imaging (rs-fMRI), and to determine the differences in time-shift value among AD, mild cognitive impairment (MCI), and normal control (NC) groups to better understand the disease. Study Type: Prospective. Subjects: Twenty-four AD, 24 MCI, and 24 age-matched NC participants. Field Strength/Sequence: T 2 *-weighted single-shot echo-planar imaging sequence was performed at 3T. In addition, a T 1 -weighted fast spoiled gradient-echo sequence was acquired for coregistration. Assessment: The brain time-shift value was determined from rs-fMRI-based blood oxygenation level-dependent (BOLD) signal in the three groups by time-shift mapping. The perfusion patterns were also investigated in the NC group. Statistical Tests: One-way analysis of variance and chi-squared tests were used to compare demographic information. The normalized time-shift maps were analyzed in a second-level test using SPM8. All analyses were evaluated with a significance level of P < 0.05 after false discovery rate (FDR) correction. Results: The time-shift maps obtained from rs-fMRI are consistent with the cerebral blood supply atlas. Compared with NC, both MCI and AD groups had less early perfusion arrival areas among the whole brain. In the delayed time-shift value for the AD group, the areas were located in the bilateral precuneus, the sensory-motor cortex in the left hemisphere, and the bilateral calcarine sulcus, which were different from the MCI group (both P < 0.05, FDR corrected). Data Conclusion: The time-shift mapping method could detect perfusion deficits in AD and MCI noninvasively. The perfusion deficits detected by rs-fMRI may provide new insight for understanding the mechanism of neurodegeneration. Level of Evidence: 2 Technical Efficacy: Stage 3

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“…Therefore, ligand design has been a significant area of interest in the field of MRI contrast. [5][6][7][8][9][10][11][12] A tetraaza tetraacetic macrocycle, more commonly referred to as DOTA (1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-tetraacetic acid) and denoted as 1 herein, was one of the earliest reported ligand systems investigated as a MRI agent. [13,14] Desreux discussed two important advantages of this ligand-set as a result of the pendant arms: (1) selectivity of metal ions due to steric effects and (2) pH-sensitive complexation.…”

Section: Introductionmentioning

confidence: 99%

Crystallographic Characterization and Non‐Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on Eu^III Electrochemistry

et al. 2018

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EuDOTA-glycine derivatives have been explored as alternatives to typical gadolinium-containing complexes for MRI agents used in diagnostic imaging. Different imaging modalities can be accessed (T1 or PARACEST) dependent on the oxidation state of the europium ion. Throughout the past 30 years, there have been significant manipulations and additions made to the DOTA scaffold; yet, characterizations related to electrochemistry and structure determined through XRD analysis have not been fully analyzed. In this work, electrochemical analysis using cyclic voltammetry was carried out on EuDOTA derivatives, including the free ligand DOTAGly4 (4) and the complexes. Effects of glycinate substitution on the DOTA scaffold, specifically, ligand interactions with the glassy carbon electrode were observed. A range of electrochemical investigations were carried out to show that increased glycinate substitution led to increased interaction with the electrode surface, thus implicating a new factor to consider when evaluating the electrochemistry of glycinate substituted ligands. In addition, the solid-state structure of EuDOTAGly4 (Eu4) was determined by X-ray diffraction and a brief analysis is presented compared to known Ln3+ structures found within literature. The Eu4 complex crystalizes in a rare polymer type arrangement via bridging side-arms between adjacent complexes.

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Advanced and amplified BOLD fluctuations in high‐grade gliomas

Abstract: 4 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;47:1616-1625.

Cited by 14 publications

References 42 publications

Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles

Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles

Detecting perfusion deficit in Alzheimer's disease and mild cognitive impairment patients by resting‐state fMRI

Crystallographic Characterization and Non‐Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on Eu^III Electrochemistry

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Advanced and amplified BOLD fluctuations in high‐grade gliomas

Abstract: 4 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;47:1616-1625.

Cited by 14 publications

References 42 publications

Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles

Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles

Detecting perfusion deficit in Alzheimer's disease and mild cognitive impairment patients by resting‐state fMRI

Crystallographic Characterization and Non‐Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on EuIII Electrochemistry

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Crystallographic Characterization and Non‐Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on Eu^III Electrochemistry