2021
DOI: 10.7759/cureus.17682
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Diagnostic Scores and Treatment Options for Acute Disseminated Intravascular Coagulation in Children

Abstract: Disseminated intravascular coagulation (DIC) is a thrombo-hemorrhagic condition that commonly accompanies life-threatening illnesses in children and is associated with significant morbidity and mortality. Treatment of underlying conditions, hemodynamic support, and replacement therapy with blood components is the mainstay of DIC management. Limited research studies have supported the use of antithrombin (AT), recombinant thrombomodulin (rTM), and protein C concentrates (PrCC). Although there have been several … Show more

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Cited by 2 publications
(1 citation statement)
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“…Concordant with other studies, 16,17 the 28-day case fatality rate of children with overt DIC or those with organ dysfunction requiring advanced organ support was significantly higher than that for children with non-overt DIC. Additionally, mortality was significantly correlated with the ISTH DIC score and the clinical parameters platelet number, prothrombin time, and D-dimer.…”
Section: Resultssupporting
confidence: 89%
“…Concordant with other studies, 16,17 the 28-day case fatality rate of children with overt DIC or those with organ dysfunction requiring advanced organ support was significantly higher than that for children with non-overt DIC. Additionally, mortality was significantly correlated with the ISTH DIC score and the clinical parameters platelet number, prothrombin time, and D-dimer.…”
Section: Resultssupporting
confidence: 89%