Diagnostic Potential of Targeted Electrical Impedance Scanning in Classifying Suspicious Breast Lesions

Wersebe, Annika; Siegmann, K. C.; Krainick, U.; Fersis, T. Nikos; Vogel, U.; Claussen, Claus D.; Müller-Schimpfle, Markus

doi:10.1097/00004424-200202000-00003

Cited by 33 publications

(25 citation statements)

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“…Moreover, one study claimed that the area under the ROC curve was significantly higher for TS2000 than other imaging methods (6). In contrast to these reports, there are two studies that found mediocre diagnostic effectiveness of impedance imaging (13,19). Our study supports the high rate of false-positive findings of TS2000 continuing to be an issue, and this limitation prevents wide clinical use of the technology.…”

Section: Discussionsupporting

confidence: 77%

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Adjunctive diagnostic value of targeted electrical impedance imaging to conventional methods in the evaluation of breast lesions

et al. 2005

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Purpose: To determine the diagnostic accuracy of targeted electrical impedance imaging in characterizing breast lesions, and to evaluate whether lesion size, depth and histopathology affect the diagnosis. Material and Methods: A total of 137 women with 145 lesions (79 malignant and 66 benign) found by palpation or mammography were prospectively enrolled in this study. The patients were examined by means of clinical breast examination, mammography, ultrasonography, and electrical impedance imaging with TransScan TS2000. A level of suspicion (LOS) post-processing algorithm (v2.67) was used for TS2000 lesion assessment. Imaging findings were correlated with cytologic (n554) and histologic diagnoses (n591). Patients with benign lesions were followed up for a mean of 36 months.Results: TS2000 showed a high sensitivity (86%) which did not differ significantly from that of mammography (87%) and ultrasonography (US) (75%). The specificity of TS2000 (49%) was significantly lower compared to mammography (97%, Pv0.0001) and US (100%, Pv0.0001). The additive use of TS2000 to mammography and US yielded no significant increase in sensitivity (97%), but the decrease in specificity was significant (46%, Pv0.0001). Diagnostic effectiveness of TS2000 (A z 50.68), as measured by the area under the ROC curve, was significantly lower than for mammography (A z 50.93, Pv0.0001) and for US (A z 50.91, Pv0.0001). When using TS2000 in addition to mammography and US (A z 50.86), a significant impairment was found (P50.0003). Conclusion: The role of targeted electrical impedance imaging as an adjunct to mammography and ultrasonography in the diagnosis of breast lesions is not justified by the result of this study.

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Section: Discussionsupporting

confidence: 77%

“…Several clinical trials have been conducted to test this modality, and these have suggested that TS2000 has adjunctive value to conventional imaging methods, especially in mammographically suspicious lesions (6,(10)(11)(12). However, other studies have not confirmed these findings (13,19).…”

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confidence: 99%

Adjunctive diagnostic value of targeted electrical impedance imaging to conventional methods in the evaluation of breast lesions

et al. 2005

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“…Malich et al have demonstrated the specifi city rates of EIS in sonographically visible and not visible benign lesions as 63 % and 67 %, respectively (25). Wersebe et al have also demonstrated comparable specifi city rates in proliferative and non-proliferative benign breast lesions as 67 % and 71 %, respectively (26). These reports have demonstrated similar, but insuffi cient outcomes to evaluate true negative results in mammographic BIRADS III lesions 13.…”

Section: Discussionmentioning

confidence: 99%

“…EIS has been recently described in many articles as an invaluable and effi cient screening modality for benign and malignant diseases of the breast (21)(22)(23)(24)(25)(26)(27). EIS evaluates the electrical activity of the breast and surrounding tissue so that lower electrical impedance-conductivity rates of the lesion compared to the surrounding tissue represent a malignant disease (28).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of breast electrical impedance imaging for clinically suspicious breast lesions

Dağlar¹,

Şenol²,

Yakut³

et al. 2016

BLL

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OBJECTIVES AND BACKGROUND: This study was designed to compare the usefulness of the breast electrical conductivity measures performed in a surgical examination room against conventional breast screening modalities for identifying the symptomatic lesions of the breast tissue. METHODS: A group of 181 patients were examined with Ultrasonography (USG), Mammography (MG), Electrical Impedance Scanning (EIS) modalities and were followed-up 24 months to clarify in terms of the lesion tumour progression relationship. Tumour biopsy was determined as an endpoint of the study. RESULTS: According to USG, 13 (7.2 %) lesion were suspicious, where as EIS was reported 22 (12.2 %). 2 of these 9 patients were presented as BI-RADS 4 and histopathologic result was proven as malignant disease during 6 months short-interval follow-up. EIS exhibited compatible sensitivity (81.2 %), accuracy (84.6 %) and PPV (81.8 %) rates with USG in BI-RADS 4 subgroup, combination of these modalities raised sensitivity rates to 92.31 %, accuracy and PPV to 100 %. EIS results in BI-RADS 3 subgroup were pointed out 77.8 % specifi city and 87.5 % NPV rates. CONCLUSION: Breast electrical impedance measures should be useful to reduce the number of the unnecessary follow-up and biopsy rates in the clinical setting (Tab. 2, Fig. 2, Ref. 39). Text in PDF www.elis.sk.

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“…TS2000 is a real-time, non-invasive method for measurement of increased conductivity and capacitance in malignant tumours and is done on the skin surface of the breast. Some studies report about varying sensitivity values even when using EIS in similar study designs [6,7,8,9,10]. From theoretical simulations it is known that the technology of electrical impedance scanning is limited in the evaluation of lesions located deeper then 3.5 cm from the skin surface [11].…”

Section: Introductionmentioning

confidence: 99%

Influence of size and depth on accuracy of electrical impedance scanning

Malich

Facius

Anderson³

et al. 2003

Eur Radiol

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Cancer cells exhibit altered local dielectric properties which can be assessed using electrical impedance scanning (EIS). The study was aimed at clarifying influence of lesion size and depth on EIS performance. From a series of 387 lesions (129 malignant and 258 benign) from 363 patients being sonographically and/or mammographically evaluated, size and depth information was not available in 112 lesions, size was available in 86 lesions and additional depth information was available in 189 lesions, respectively, while performing EIS. Lesions were either histologically verified or had a follow-up of at least 2 years. One hundred three of 129 malignant lesions and 165 of 258 benign lesions were correctly detected (sensitivity 79.8%, specificity 64.0%, accuracy 71.9%). Sensitivity without knowledge of size and depth was 64.6% (10 of 16 malignant lesions detected). This value increased to 76.2% (32 of 42) with knowledge of the size and further increased to 85.9% with knowledge of size and depth (61 of 71). Specificity values in the three subgroups were almost similar: 64.6 (62 of 96), 65.9 (29 of 44), and 62.7% (74 of 118), respectively. Accuracy rises from 63.6% (without knowledge of size/depth) to 71.1 and 74.3% (with size knowledge and with size and depth knowledge, respectively). Accuracy of EIS improved significantly by including sonographical information about depth and size into the analysis. Ultrasound examination should be performed prior to EIS.

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Diagnostic Potential of Targeted Electrical Impedance Scanning in Classifying Suspicious Breast Lesions

Abstract: EIS showed mediocre overall diagnostic accuracy for classifying suspicious breast lesions. Quantitative analysis of positive EIS findings did not help to differentiate between false and true positive spots.

Cited by 33 publications

References 10 publications

Adjunctive diagnostic value of targeted electrical impedance imaging to conventional methods in the evaluation of breast lesions

Adjunctive diagnostic value of targeted electrical impedance imaging to conventional methods in the evaluation of breast lesions

Effectiveness of breast electrical impedance imaging for clinically suspicious breast lesions

Influence of size and depth on accuracy of electrical impedance scanning

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