Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors

Weber, Marc‐André; Zoubaa, Saida; Schlieter, Martin; Jüttler, Eric; Huttner, Hagen B.; Geletneky, Karsten; Ittrich, Carina; Lichy, Matthias P.; Kröll, A.; Debus, Jürgen; Giesel, Frederik L.; Hartmann, Marius; Essig, Marco

doi:10.1212/01.wnl.0000219767.49705.9c

Cited by 245 publications

(197 citation statements)

References 30 publications

(44 reference statements)

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“…( 43 – 45 ) Magnetic resonance perfusion uses differences in regional cerebral blood flow and vessel permeability to determine the likelihood of malignancy (46) . Clinicopathologic correlations are underway to establish the utility of MRS or MR perfusion in grading gliomas.…”

Section: Discussionmentioning

confidence: 99%

Intensity modulated radiation therapy versus three‐dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison

MacDonald

Ahmad

Kachris

et al. 2007

J Applied Clin Med Phys

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The present study compared the dosimetry of intensity‐modulated radiation therapy (IMRT) and three‐dimensional conformal radiation therapy (3D‐CRT) techniques in patients treated for high‐grade glioma. A total of 20 patients underwent computed tomography treatment planning in conjunction with magnetic resonance imaging fusion. Prescription dose and normal‐tissue constraints were identical for the 3D‐CRT and IMRT plans. The prescribed dose was 59.4 Gy delivered at 1.8 Gy per fraction using 4 – 10 MV photons. Normal‐tissue dose constraints were 50 – 54 Gy for the optic chiasm and nerves, and 55 – 60 Gy for the brainstem.The IMRT plan yielded superior target coverage as compared with the 3D‐CRT plan. Specifically, minimum and mean planning target volume cone down doses were 54.52 Gy and 61.74 Gy for IMRT and 50.56 Gy and 60.06 Gy for 3D‐CRT (p≤0.01). The IMRT plan reduced the percent volume of brainstem receiving a dose greater than 45 Gy by 31% (p=0.004) and the percent volume of brain receiving a dose greater than 18 Gy, 24 Gy, and 45 Gy by 10% (p=0.059), 14% (p=0.015), and 40% (p≤0.0001) respectively. With IMRT, the percent volume of optic chiasm receiving more than 45 Gy was also reduced by 30.40% (p=0.047). As compared with 3D‐CRT, IMRT significantly increased the tumor control probability (p≤0.005) and lowered the normal‐tissue complication probability for brain and brainstem (p<0.033).Intensity‐modulated radiation therapy improved target coverage and reduced radiation dose to the brain, brainstem, and optic chiasm. With the availability of new cancer imaging tools and more effective systemic agents, IMRT may be used to intensify tumor doses while minimizing toxicity, therefore potentially improving outcomes in patients with high‐grade glioma.PACs number: 87.53 Tf

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Section: Discussionmentioning

confidence: 99%

Intensity modulated radiation therapy versus three‐dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison

MacDonald

Ahmad

Kachris

et al. 2007

J Applied Clin Med Phys

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“…Furthermore, ASL perfusion has consistently shown higher CBF values in high-grade than in low-grade gliomas [25][26][27]. However, the main parameter of interest is the CBV, depicting the overall tumour vascularity, which allows indirect assessment of tumour angiogenesis [5].…”

Section: Location Dependence Of Tumour-to-gm Ratios and Parametric Vamentioning

confidence: 99%

Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours

Westen

Petersen

Wirestam

et al. 2011

Magn Reson Mater Phy

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Objective: To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours Conclusion:These results suggest that measurement of aBV is a potential tool for non-invasive assessment of blood volume in intracranial tumours.

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“…51 ASL studies of human brain tumors, however, show heterogeneous perfusion patterns. [52][53][54] This is not unexpected in the light of known heterogeneity of oxygenation in many brain tumor types. Interestingly, ASL perfusion measurements indicate that astrocytic tumors can be graded as low or high grade tumors by means of quantitative perfusion.…”

Section: Asl and Blood Volume Mri: Probing Hemodynamics And Vascular mentioning

confidence: 78%

“…Interestingly, ASL perfusion measurements indicate that astrocytic tumors can be graded as low or high grade tumors by means of quantitative perfusion. Low grade gliomas show lower maximum perfusion than high grade gliomas, [52][53][54] yet the global perfusion in all glioma classes does not differ. 54 High grade gliomas show higher blood flow than CNS lymphomas.…”

Section: Asl and Blood Volume Mri: Probing Hemodynamics And Vascular mentioning

confidence: 84%

Using magnetic resonance imaging and spectroscopy in cancer diagnostics and monitoring

Kauppinen

Peet

2011

Cancer Biology & Therapy

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Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors

Abstract: Perfusion MRI is predictive in distinguishing glioblastomas from metastases, CNS lymphomas and other gliomas vs MRI and magnetic resonance spectroscopy.

Cited by 245 publications

References 30 publications

Intensity modulated radiation therapy versus three‐dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison

Intensity modulated radiation therapy versus three‐dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison

Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours

Using magnetic resonance imaging and spectroscopy in cancer diagnostics and monitoring

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