Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours

Westen, Danielle van; Petersen, Esben Thade; Wirestam, Ronnie; Siemund, Roger; Bloch, Karin Markenroth; Ståhlberg, Freddy; Björkman–Burtscher, Isabella M.; Knutsson, Linda

doi:10.1007/s10334-011-0255-x

Cited by 34 publications

(36 citation statements)

References 29 publications

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“…Another ASL based approach is to employ a two-stage model to analyze multi-TI ASL data for arterial blood volume estimation, which also includes substantial contribution from large arteries (54). It has been shown that ASL based arterial blood volume correlated with DSC CBV in brain tumors and increased with tumor grade (53,54), generally consistent with our results. Many other methods have been developed for CBVa measurement.…”

Section: Discussionsupporting

confidence: 92%

Measurement of arteriolar blood volume in brain tumors using MRI without exogenous contrast agent administration at 7T

Agarwal

Jones

et al. 2016

Magnetic Resonance Imaging

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Purpose Arteriolar cerebral-blood-volume (CBVa) is an important perfusion parameter that can be measured using inflow-based vascular-space-occupancy (iVASO) MRI without exogenous contrast agent administration. The purpose of this study is to assess the potential diagnostic value of CBVa in brain tumor patients by comparing it with total-CBV (including arterial, capillary and venous vessels) measured by dynamic-susceptibility-contrast (DSC) MRI. Methods Twelve brain tumor patients were scanned using iVASO (on 7T as part of a research project) and DSC (on 3T as part of routine clinical protocols) MRI. Region-of-interest analysis was performed to compare the resulting perfusion measures between tumoral and contralateral regions, and to evaluate their associations with tumor grades. Results CBVa measured by iVASO-MRI significantly correlated with WHO grade (ρ=0.37, P=0.04). Total-CBV measured by DSC-MRI showed a trend of correlation with WHO grade (ρ=0.28, P=0.5). Signal-to-noise ratio was comparable (P>0.1) between the two methods, while contrast-to-noise ratio between tumoral and contralateral regions was higher in iVASO-CBVa than DSC-CBV in WHO II/III patients (P<0.05) but comparable in WHO IV patients (P>0.1). A trend of positive correlation between DSC-CBV and iVASO-CBVa was observed (R2=0.28, P=0.07). Conclusion In this initial patient study, CBVa demonstrated a stronger correlation with WHO grade than total-CBV. Further investigation with a larger cohort is warranted to validate whether CBVa can be a better classifier than total-CBV for the stratification of brain tumors, and whether iVASO-MRI can be a useful alternative method for the assessment of tumor perfusion, especially when exogenous contrast agent administration is difficult in certain patient populations.

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Section: Discussionsupporting

confidence: 92%

Measurement of arteriolar blood volume in brain tumors using MRI without exogenous contrast agent administration at 7T

Agarwal

Jones

et al. 2016

Magnetic Resonance Imaging

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“…In the past, there have been several brain tumor studies that compared ASL CBF with DSC rCBF (11,21,22) or with both DSC rCBF and rCBV parameters (12,13,23,24). The present study included comparisons of ASL CBF with additional DSC MRI parameters, including Tmax and MTT.…”

Section: Discussionmentioning

confidence: 99%

Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors

et al. 2016

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“…In addition, a well-known disadvantage of ASL involves cases of severe ischemia in which prolonged arterial transit times can result in relaxation of the spin label and produce underestimation of CBF [35]. Furthermore, ASL can currently provide values only of CBF; however, some recent technical developments may be able to derive a blood volume value from ASL techniques in the future [36]. …”

Section: Question 2: Which Methods Are Currently Available To Assess mentioning

confidence: 99%

Perfusion MRI: The Five Most Frequently Asked Technical Questions

Essig¹,

Shiroishi²,

Nguyen³

et al. 2013

American Journal of Roentgenology

312

238

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OBJECTIVE This and its companion article address the 10 most frequently asked questions that radiologists face when planning, performing, processing, and interpreting different MR perfusion studies in CNS imaging. CONCLUSION Perfusion MRI is a promising tool in assessing stroke, brain tumors, and patients with neurodegenerative diseases. Most of the impediments that have limited the use of perfusion MRI can be overcome to allow integration of these methods into modern neuroimaging protocols.

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Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours

Cited by 34 publications

References 29 publications

Measurement of arteriolar blood volume in brain tumors using MRI without exogenous contrast agent administration at 7T

Measurement of arteriolar blood volume in brain tumors using MRI without exogenous contrast agent administration at 7T

Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors

Perfusion MRI: The Five Most Frequently Asked Technical Questions

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