Diagnostic performance of plasma biomarkers in patients with acute intestinal ischaemia

Abstract

Serum biomarkers may be useful in the diagnosis of vascular, but not non-vascular, intestinal ischaemia. Among them, I-FABP shows promise for detecting vascular ischaemia.

Role of serum lactic dehydrogenase, glutamic oxaloacetic transaminase, creatine phosphokinase, alkaline phospatase, serum phosphorus in the cases of bowel ischemia in acute abdomen

“…22 Sensitivity and specificity for elevated levels of SGOT were 68% and 80% respectively in present study whereas other studies reported higher sensitivity of 70% to 80% and same specificity of 80%-90% for elevated serum SGOT in bowel ischemia patients. 20,23 They reported serum level of >100 U significant for bowel ischemia in the comparison of non-bowel ischemic patients which was similar to our study findings, in which we found SGOT levels >100 U significantly (p value <0.0001) related to bowel ischemia patients. 20 In present study for elevated levels of alkaline phosphates sensitivity and specificity were 72% and 68% respectively whereas others reported similar sensitivity of up to 70% to 80% but slight higher specificity of 70% to 80% in their study.…”

“…20,23 They reported serum level of >100 U significant for bowel ischemia in the comparison of non-bowel ischemic patients which was similar to our study findings, in which we found SGOT levels >100 U significantly (p value <0.0001) related to bowel ischemia patients. 20 In present study for elevated levels of alkaline phosphates sensitivity and specificity were 72% and 68% respectively whereas others reported similar sensitivity of up to 70% to 80% but slight higher specificity of 70% to 80% in their study. 10,24,25 They stated level >140 U was specific for bowel ischemia, which was found to be similar to present study.…”

“…[11][12][13] In present study for elevated level of lactate dehydrogenase, sensitivity and specificity were found to be 88% and 68% respectively similar to the findings of other studies in which they reported 80% to 90% sensitivity and specificity of 60% to 70% but some studies reported low specificity of 44% for elevated level of LDH level in bowel ischemia patients. 20,21 LDH levels >800 U/L was significantly (p value <0.0001) related to bowel ischemia in comparison to without bowel ischemia patients in present study. In other studies findings, higher level (>1000 IU/L) of serum LDH indicated bowel ischemic changes.…”

Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

“…A vékonybél ischaemiás toleranciája 6 óra, ezt követően irreverzibilisen károsodik, ezért a korai diagnózis létfon-tosságú. Néhány humán vizsgálat során sikerült igazolni, hogy a szérum-I-FABP szintje megemelkedik az arteria mesenterica superior occlusiója esetén [8,15,[18][19][20][21]. Egy patkányokat használó kísérletes modellben az SE I. Sebészeti Klinika munkacsoportja kimutatta, hogy a szé-rum-I-FABP szintjének emelkedése jól korrelál a szövet-tani minták elemzése során talált intestinalis epithelsejtkárosodás mértékével [22].…”

Acute Mesenteric Ischemia

“…Elevated amylase has been reported in roughly a half of patients with AMI [29]. Other biomarkers reported to assist in the diagnosis of AMI include intestinal fatty acid binding protein (I-FABP), serum alpha-glutathione S-transferase (alpha-GST), and cobalt-albumin binding assay (CABA) [30,31]. These biomarkers may offer improved diagnostic accuracy of acute mesenteric ischemia, however, further research is required to specify its accuracy and values.…”