Abstract:Background
Central nervous system (CNS) aspergillosis is an uncommon but fatal disease, the diagnosis of which is still difficult.
Objectives
We aim to explore the diagnositic performance of noncultural methods for CNS aspergillosis.
Methods
In this retrospective study, all pathologically confirmed rhinosinusitis patients in whom cerebrospinal fluid (CSF) galactomannan (GM) test and metagenomic next‐generation sequencing (mNGS) had been performed were included. We evaluated the diagnostic performances of CSF G… Show more
“…Isolate information provided by the laboratory was based on phenotypic identification. Aspergillus DNA from respiratory samples was detected by a metagenomic next-generation sequencing technique following library construction and bioinformatic analysis through standard analytic workflows as described previously ( 13 ).…”
There are concerns on avoiding diagnostic delay and misdiagnosis for chronic pulmonary aspergillosis due to its high morbidity and mortality. A proportion of CPA patients test negative for
Aspergillus
IgG.
“…Isolate information provided by the laboratory was based on phenotypic identification. Aspergillus DNA from respiratory samples was detected by a metagenomic next-generation sequencing technique following library construction and bioinformatic analysis through standard analytic workflows as described previously ( 13 ).…”
There are concerns on avoiding diagnostic delay and misdiagnosis for chronic pulmonary aspergillosis due to its high morbidity and mortality. A proportion of CPA patients test negative for
Aspergillus
IgG.
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