Diagnostic performance of low-dose chest CT to detect COVID-19: A Turkish population study

Aslan, Serdar; Bekçi, Tümay; Çakır, İsmet Miraç; Ekiz, Mehmet; Yavuz, İlknur; Şahin, Ahmet

doi:10.5152/dir.2020.20350

Cited by 16 publications

(21 citation statements)

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“…The search strategy and cross-referencing searches yielded 395 results. After duplicate screening of title and abstract 70 references were selected for full text review of which 30 met selection criteria and were included: 11 systematic reviews (5,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) and 19 primary diagnostic accuracy studies (12,(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49).…”

Section: Search Resultsmentioning

confidence: 99%

“…The search strategy and cross-referencing searches yielded 395 results. After duplicate screening of title and abstract 70 references were selected for full text review of which 30 met selection criteria and were included: 11 systematic reviews ( 5 , 22 – 31 ) and 19 primary diagnostic accuracy studies ( 12 , 32 – 49 ). Reasons for exclusion were related to not having a DTA design: only COVID-19 patients; only abnormal CT scans; not reporting data to compute sensitivity and specificity; or using single RT-PCR as a reference standard in all patients.…”

Section: Resultsmentioning

confidence: 99%

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An Umbrella Review With Meta-Analysis of Chest Computed Tomography for Diagnosis of COVID-19: Considerations for Trauma Patient Management

et al. 2022

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BackgroundRT-PCR testing is the standard for diagnosis of COVID-19, although it has its suboptimal sensitivity. Chest computed tomography (CT) has been proposed as an additional tool with diagnostic value, and several reports from primary and secondary studies that assessed its diagnostic accuracy are already available. To inform recommendations and practice regarding the use of chest CT in the in the trauma setting, we sought to identify, appraise, and summarize the available evidence on the diagnostic accuracy of chest CT for diagnosis of COVID-19, and its application in emergency trauma surgery patients; overcoming limitations of previous reports regarding chest CT accuracy and discussing important considerations regarding its role in this setting.MethodsWe conducted an umbrella review using Living Overview of Evidence platform for COVID-19, which performs regular automated searches in MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and more than 30 other sources. The review was conducted following the JBI methodology for systematic reviews. The Grading of Recommendations, Assessment, Development, and Evaluation approach for grading the certainty of the evidence is reported (registered in International Prospective Register of Systematic Reviews, CRD42020198267).ResultsThirty studies that fulfilled selection criteria were included; 19 primary studies provided estimates of sensitivity (0.91, 95%CI = [0.88–0.93]) and specificity (0.73, 95%CI = [0.61; 0.82]) of chest CT for COVID-19. No correlation was found between sensitivities and specificities (ρ = 0.22, IC95% [–0.33; 0.66]). Diagnostic odds ratio was estimated at: DOR = 27.5, 95%CI (14.7; 48.5). Evidence for sensitivity estimates was graded as MODERATE, and for specificity estimates it was graded as LOW.ConclusionThe value of chest CT appears to be that of an additional screening tool that can easily detect PCR false negatives, which are reportedly highly frequent. Upon the absence of PCR testing and impossibility to perform RT-PCR in trauma patients, chest CT can serve as a substitute with increased value and easy implementation.Systematic Review Registration[www.crd.york.ac.uk/prospero], identifier [CRD42020198267].

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Section: Search Resultsmentioning

confidence: 99%

“…The search strategy and cross-referencing searches yielded 395 results. After duplicate screening of title and abstract 70 references were selected for full text review of which 30 met selection criteria and were included: 11 systematic reviews ( 5 , 22 – 31 ) and 19 primary diagnostic accuracy studies ( 12 , 32 – 49 ). Reasons for exclusion were related to not having a DTA design: only COVID-19 patients; only abnormal CT scans; not reporting data to compute sensitivity and specificity; or using single RT-PCR as a reference standard in all patients.…”

Section: Resultsmentioning

confidence: 99%

An Umbrella Review With Meta-Analysis of Chest Computed Tomography for Diagnosis of COVID-19: Considerations for Trauma Patient Management

et al. 2022

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“…The first novel coronavirus SARS-CoV-2 outbreak was reported to WHO on December 31 2019 from the Hubei Province of the People's Republic of China [1,2]. On January 30, 2020, the WHO declared COVID-19 as an international emergency that threatened public health, as a pandemic on March 11, 2020 [3]. COVID-19 may be asymptomatic or mild or may have a clinical course that may cause severe pneumonia requiring hospitalization and even intensive care [4].…”

Section: Introductionmentioning

confidence: 99%

The effect of national restrictions on computed tomography severity score and the prognosis of COVID-19

Çakır¹,

Bekçi²,

Aslan³

et al. 2022

Journal of Surgery and Medicine

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Background/Aim: The SARS-CoV-2 pandemic is spreading rapidly all over the world and has high mortality rates. Governments implement quarantine or restrictions to prevent the virus from getting out of control. Computed Tomography (CT) has an important place in the diagnosis of COVID-19 and patient management. This study aimed to evaluate the changes in chest CT findings and the disease prognosis of COVID-19 pneumonia during the restriction and post-restriction periods. Methods: A total of 1150 patients whose COVID-19 disease was confirmed by a reverse transcriptasepolymerase chain reaction and who underwent chest CT examination between April 1-September 30, 2020 were included in this retrospective cohort study. The participants were categorized into two groups according to CT examination dates, as during (April 1-May 31), and after the restriction periods (June 1-September 30). Each patient's CT severity score (CTSS) was calculated, and the need for admission to the intensive care unit (ICU) and mortality related to COVID-19 were noted for statistical analysis. Results: Of the 1150 cases, 213 were in the restriction period group (RPG), while 937 were in the postrestriction period group (PRPG). The median value of CTSS was 5 in the RPG, and 6 in the PRPG (P=0.095). In the RPG and PRPG, the number of patients who needed ICU admission were 20 (9.4%), and 50 (5.3%), respectively, while 12 (7%) and 39 (4.2%) patients, respectively, died from COVID-19. Both parameters were comparable between the two groups (P=0.073, P=0.060 respectively). Conclusion:The restrictions did not change the severity of the COVID-19 disease, ICU hospitalization rate, and death rate.

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“…SUCRA Values of 3 Different methods for diagnosis of SARS-CoV-2 infection by PCR. List of studies included in the analysis, see [ 19 , 28 , 39 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ,…”

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confidence: 99%

Diagnostic Performance of Antigen Rapid Diagnostic Tests, Chest Computed Tomography, and Lung Point-of-Care-Ultrasonography for SARS-CoV-2 Compared with RT-PCR Testing: A Systematic Review and Network Meta-Analysis

et al. 2022

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(1) Background: The comparative performance of various diagnostic methods for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remains unclear. This study aimed to investigate the comparison of the 3 index test performances of rapid antigen diagnostic tests (RDTs), chest computed tomography (CT), and lung point-of-care-ultrasonography (US) with reverse transcription-polymerase chain reaction (RT-PCR), the reference standard, to provide more evidence-based data on the appropriate use of these index tests. (2) Methods: We retrieved data from electronic literature searches of PubMed, Cochrane Library, and EMBASE from 1 January 2020, to 1 April 2021. Diagnostic performance was examined using bivariate random-effects diagnostic test accuracy (DTA) and Bayesian network meta-analysis (NMA) models. (3) Results: Of the 3992 studies identified in our search, 118 including 69,445 participants met our selection criteria. Among these, 69 RDT, 38 CT, and 15 US studies in the pairwise meta-analysis were included for DTA with NMA. CT and US had high sensitivity of 0.852 (95% credible interval (CrI), 0.791–0.914) and 0.879 (95% CrI, 0.784–0.973), respectively. RDT had high specificity, 0.978 (95% CrI, 0.960–0.996). In accuracy assessment, RDT and CT had a relatively higher than US. However, there was no significant difference in accuracy between the 3 index tests. (4) Conclusions: This meta-analysis suggests that, compared with the reference standard RT-PCR, the 3 index tests (RDTs, chest CT, and lung US) had similar and complementary performances for diagnosis of SARS-CoV-2 infection. To manage and control COVID-19 effectively, future large-scale prospective studies could be used to obtain an optimal timely diagnostic process that identifies the condition of the patient accurately.

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Diagnostic performance of low-dose chest CT to detect COVID-19: A Turkish population study

Cited by 16 publications

References 0 publications

An Umbrella Review With Meta-Analysis of Chest Computed Tomography for Diagnosis of COVID-19: Considerations for Trauma Patient Management

An Umbrella Review With Meta-Analysis of Chest Computed Tomography for Diagnosis of COVID-19: Considerations for Trauma Patient Management

The effect of national restrictions on computed tomography severity score and the prognosis of COVID-19

Diagnostic Performance of Antigen Rapid Diagnostic Tests, Chest Computed Tomography, and Lung Point-of-Care-Ultrasonography for SARS-CoV-2 Compared with RT-PCR Testing: A Systematic Review and Network Meta-Analysis

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