Diagnostic Performance of FDG-PET/CT Scan as Compared to US-Guided FNA in Prediction of Axillary Lymph Node Involvement in Breast Cancer Patients

Assi, Hazem; Alameh, Ibrahim; Khoury, Jessica; Zerdan, Maroun Bou; Akiki, Vanessa; Charafeddine, Maya; Saheb, Ghida; Sukhon, Fares; Sbaity, Eman; Baydoun, Serine; Shabb, Nina S.; Berjawi, Ghina; Haidar, Mohamad

doi:10.3389/fonc.2021.740336

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Computed tomography and Fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET/CT) has been demonstrated to identify previously undetected distant metastases and patients with recently diagnosed breast cancer and extra-axillary regional nodal metastases, which has an impact on staging, therapy, and prognosis [3].…”

Section: Introductionmentioning

confidence: 99%

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

Esmail,

Abdulsalam,

Khatab

et al. 2023

Zagazig University Medical Journal

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Background: People of various races, ages, financial backgrounds, and geographic areas are typically affected by breast cancer, which is the most common malignant disease in women. After a diagnosis of breast cancer, a precise assessment of tumor staging is necessary to establish the course of treatment and prognosis. Aim: To investigate the role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in staging, pre-therapeutic metastatic workup or preoperative evaluation of newly diagnosed patients with breast cancer which subsequently affects their management. Patients and methods: This prospective study included 30 female patients who were recently diagnosed as breast cancer and were referred for initial 18F-FDG PET/CT scans for preoperative or pre-therapeutic staging. All patients underwent both CT and PET examinations for initial staging of breast cancer. The reference standard was histopathology and 6-12 months follow-up. Results: PET/CT revealed higher sensitivity (92%) and specificity (80%) in diagnosis of nodal metastasis compared to conventional CT with lower sensitivity (64%) and specificity (60%). Also, PET/CT had higher sensitivity (94.4%) and specificity (75%) in diagnosis of distant metastasis compared to conventional CT with lower sensitivity (88.9%) and specificity (66.7%). Conclusions:The quick, accurate, and noninvasive metastasis detection provided by (18F-FDG PET/CT) is valuable as it allows for the modification of the initial staging, which in turn affects the treatment regimens for newly diagnosed breast cancer patients.

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Section: Introductionmentioning

confidence: 99%

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

Esmail,

Abdulsalam,

Khatab

et al. 2023

Zagazig University Medical Journal

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A case of grade1 follicular lymphoma diagnosed by laparoscopic lymph node resection: differentiating from late lymph node recurrence of endometrial cancer

Koyama,

Okamoto,

Yamanoi

et al. 2024

Int Canc Conf J

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Reliability of predicting low-burden (≤ 2) positive axillary lymph nodes indicating sentinel lymph node biopsy in primary operable breast cancer — a retrospective comparative study with PET/CT and breast MRI

Sae-lim,

Wu,

Chang

et al. 2024

World J Surg Onc

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Background Sentinel lymph node biopsy (SLNB) is the standard of care for axillary staging in early breast cancer patients with low-burden axillary metastasis (≤ 2 positive nodes). This study aimed to determine the diagnostic performances of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and breast magnetic resonance imaging in detecting axillary lymph node (ALN) metastases and the reliability to predict ALN burden. Methods A total of 275 patients with primary operable breast cancer receiving preoperative PET/CT and upfront surgery from January 2001 to December 2022 in a single institution were enrolled. A total of 244 (88.7%) of them also received breast MRI. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT and breast MRI were assessed. The predictive values to determine ALN burden were evaluated using radio-histopathological concordance. Results PET/CT demonstrated a sensitivity of 53.4%, specificity of 82.1%, PPV of 65.5%, NPV of 73.5%, and accuracy of 70.9% for detecting ALN metastasis, and the corresponding values for MRI were 71.8%, 67.8%, 56%, 80.8%, and 69.2%, respectively. Combining PET/CT and MRI showed a significantly higher PPV than MRI (72.7% vs 56% for MRI alone, p = 0.037) and a significantly higher NPV than PET/CT (84% vs 73.5% for PET/CT alone, p = 0.041). For predicting low-burden axillary metastasis (1–2 positive nodes), the PPVs were 35.9% for PET/CT, 36.7% for MRI, and 55% for combined PET/CT and MRI. Regarding patients with 0–2 positive ALNs in imaging, who were indicated for SLNB, the predictive correctness was 96.1% for combined PET/CT and MRI, 95.7% for MRI alone, and 88.6% for PET/CT alone. Conclusions PET/CT and breast MRI exhibit high predictive values for identifying low-burden axillary metastasis in patients with operable breast cancer with ≦ 2 positive ALNs on imaging.

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Diagnostic Performance of FDG-PET/CT Scan as Compared to US-Guided FNA in Prediction of Axillary Lymph Node Involvement in Breast Cancer Patients

Cited by 4 publications

References 29 publications

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

A case of grade1 follicular lymphoma diagnosed by laparoscopic lymph node resection: differentiating from late lymph node recurrence of endometrial cancer

Reliability of predicting low-burden (≤ 2) positive axillary lymph nodes indicating sentinel lymph node biopsy in primary operable breast cancer — a retrospective comparative study with PET/CT and breast MRI

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