Diagnostic performance of computed tomographic coronary angiography in patients with end-stage renal disease

Jug, Borut; Papazian, Jenny; Gupta, Mohit; Bhatia, Harpreet; Derakhshani, Arya; Koplik, Sheri; Karlsberg, Ronald P.; Budoff, Matthew J.

doi:10.1097/mca.0b013e32835be39a

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…Three studies [13, 20, 21] contained enough information to populate the requisite contingency table to assess diagnostic performance at the patient level. Two studies [19, 20] contained enough information to complete the contingency table at the vessel level.…”

Section: Resultsmentioning

confidence: 99%

“…Such a study design will naturally overestimate the sensitivity of CCTA. In Jug et al [21], a part of the cohort came from the prospective ACCURACY trial and the rest came from a retrospective cohort, but details of the retrospective cohort and indications for the CCTA and invasive coronary angiograms were unclear. Given the high probability that only patients with positive CCTA results underwent invasive coronary angiography, the design again will overestimate the sensitivity of CCTA.…”

Section: Resultsmentioning

confidence: 99%

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Coronary Computed Tomography Angiography in Diagnosing Obstructive Coronary Artery Disease in Patients with Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis

et al. 2020

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Introduction: Coronary computed tomography angiography (CCTA) is emerging as an important noninvasive testing modality for coronary angiography. The performance characteristic of CCTA in patients with advanced kidney disease is unknown. Methods: We performed a systematic review and meta-analysis of studies specifically investigating the sensitivity and specificity of CCTA compared to coronary angiogram as a reference standard in patients with advanced kidney disease, defined as dialysis dependence or nearing kidney transplantation. Two independent investigators assessed studies for inclusion/exclusion, quality, and characteristics, while a third investigator adjudicated. Results: We identified 4 studies including a total of 217 patients, of whom 159 were dialysis dependent. Three of the 4 studies had a high risk of bias in patient selection and study flow, while 1 study rated low in all areas of bias. The studies were heterogeneous in their patient selection and CCTA protocol but consistent in their definition of obstructive coronary artery disease. The pooled sensitivity and specificity for CCTA were 0.96 (0.87–0.99) and 0.66 (0.57–0.74), respectively. When we restricted the analysis to dialysis-dependent patients, the pooled sensitivity and specificity for CCTA were 0.99 (0.74–1.00) and 0.67 (0.49–0.82), respectively. Conclusions: Based on limited data, CCTA appears to have comparable sensitivity but lower specificity relative to the non-kidney disease population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Coronary Computed Tomography Angiography in Diagnosing Obstructive Coronary Artery Disease in Patients with Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis

et al. 2020

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“…If subjects had β-blocker contraindications or unsatisfactory HR reduction after medication (higher than 70 bpm), the examination was not continued. The main CT parameters were previously described ( 8 , 9 ). The reconstruction of original images was based on the scanning data to obtain the corresponding R-R interval.…”

Section: Methodsmentioning

confidence: 99%

Computed tomography imaging of early coronary artery lesions in stable individuals with multiple cardiovascular risk factors

Yang¹,

Huang²,

Liu³

et al. 2015

Clinics

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OBJECTIVES:To investigate the prevalence, extent, severity, and features of coronary artery lesions in stable patients with multiple cardiovascular risk factors.METHODS:Seventy-seven patients with more than 3 cardiovascular risk factors were suspected of having coronary artery disease. Patients with high-risk factors and 39 controls with no risk factors were enrolled in the study. The related risk factors included hypertension, impaired glucose tolerance, dyslipidemia, smoking history, and overweight. The characteristics of coronary lesions were identified and evaluated by 64-slice coronary computed tomography angiography.RESULTS:The incidence of coronary atherosclerosis was higher in the high-risk group than in the no-risk group. The involved branches of the coronary artery, the diffusivity of the lesion, the degree of stenosis, and the nature of the plaques were significantly more severe in the high-risk group compared with the no-risk group (all p < 0.05).CONCLUSION:Among stable individuals with high-risk factors, early coronary artery lesions are common and severe. Computed tomography has promising value for the early screening of coronary lesions.

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“…The average duration of dialysis relative to when the CCTA was acquired was 52.3 (40.7) months, comparable to prior studies. 12 History of previous cardiovascular events included prior MI (37.5%), stroke (19.6%), and current chest pain (24.7%).…”

Section: Study Populationmentioning

confidence: 99%

“…11 Despite the expected high prevalence of calcified plaque, Jug et al showed high per-patient diagnostic performance for detecting significant stenosis using CCTA in ESRD patients compared to conventional coronary angiography. 12 Recent developments have allowed for a more accurate quantitative assessment of both the type and volume of coronary atherosclerosis. Recent single and multicenter studies have shown that quantitative evaluation of coronary artery plaque on CCTA can identify patients at risk of subsequent cardiac events and culprit lesions in patients who subsequently experience a myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Quantitative plaque analysis with A.I.-augmented CCTA in end-stage renal disease and complex CAD

Cho¹,

Ghanem²,

Quesada

et al. 2022

Clinical Imaging

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Diagnostic performance of computed tomographic coronary angiography in patients with end-stage renal disease

Cited by 6 publications

References 31 publications

Coronary Computed Tomography Angiography in Diagnosing Obstructive Coronary Artery Disease in Patients with Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Coronary Computed Tomography Angiography in Diagnosing Obstructive Coronary Artery Disease in Patients with Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Computed tomography imaging of early coronary artery lesions in stable individuals with multiple cardiovascular risk factors

Quantitative plaque analysis with A.I.-augmented CCTA in end-stage renal disease and complex CAD

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