Diagnostic performance of a novel dedicated breast PET scanner with C-shaped ring detectors

Nakamoto, Ryusuke; Nakamoto, Yuji; Ishimori, Takayoshi; Nishimatsu, Kayo; Miyake, Kanae; Kanao, Shotaro; Iima, Mami; Toi, Masakazu; Togashi, Kaori

doi:10.1097/mnm.0000000000000661

Cited by 16 publications

(12 citation statements)

References 23 publications

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“…The PUV lacks attenuation and scatter correction and thereby differs from the standardized uptake value (SUV) used in whole-body PET or PET/CT, although maximum PUV and maximum SUV were highly correlated (r= 0.79) in a study by Wang et al 22 . For dedicated breast PET detectors, the maximum uptake value for lesions on dbPET was found to be higher than WBPET SUV for corresponding lesions 23,24 . Narayanan et al 17 showed that both LTB and PUV max were significantly greater (p<0.001) across all malignant lesions compared to all benign lesions.…”

Section: Imaging Techniques and Interpretationmentioning

confidence: 87%

Dedicated Breast Gamma Camera Imaging and Breast PET

Narayanan

Berg

2018

PET Clinics

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Recent advances in nuclear medicine instrumentation have led to the emergence of improved molecular imaging techniques to image breast cancer: dedicated gamma cameras using γ-emitting Tc-sestamibi and breast-specific PET cameras usingF-fluorodeoxyglucose. This article focuses on the current role of such approaches in the clinical setting including diagnosis, assessing local extent of disease, monitoring response to therapy, and, for gamma camera imaging, possible supplemental screening in women with dense breasts. Barriers to clinical adoption and technologies and radiotracers under development are also discussed.

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Section: Imaging Techniques and Interpretationmentioning

confidence: 87%

Dedicated Breast Gamma Camera Imaging and Breast PET

Narayanan

Berg

2018

PET Clinics

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“…This device known as C-scanner, consists of 24 detector blocks arranged in two contiguous rings. Its evaluation in 159 women showed a lesion-based sensitivity of 81.1% increasing to 93% when lesions outside the FOV of the system were excluded (35).…”

Section: A B C Dmentioning

confidence: 99%

Novel frontiers of dedicated molecular imaging in breast cancer diagnosis

Collarino¹,

Fuoco²,

Arias-Bouda³

et al. 2018

Transl. Cancer Res

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Breast cancer (BC) is the most common cancer in women worldwide. In the last years, the contribution of nuclear medicine has grown based on the use of dedicated molecular breast devices for diagnosis and biopsy. Recent technical improvements have been achieved in order to increase the detection of smaller breast lesions using lower doses of radiotracers as well as to facilitate accurate biopsy sampling. Furthermore, new prototypes have been developed combining anatomic and functional imaging. Although the gamma-emitting 99m Tc-sestamibi ( 99m Tc-MIBI) and the positron-emitting 18 F-fluorodeoxyglucose ( 18 F-FDG) are the most widely used radiotracers, several new tracers have been investigated to target more specific biologic features of BC like proliferation, angiogenesis and tumour receptor status. Dedicated molecular breast devices have been introduced as an adjunct imaging tool to mammography (MG) and ultrasound (US) in the clinical work-up for BC. Additionally, due to the increased interest in molecular tumour subtype analysis and ribonucleic acid (RNA)-based gene expression profiling tests in the routine clinical practice, a possible new clinical application of dedicated breast imaging concerns locally advanced BC, principally in order to visualise intra-tumour metabolic heterogeneity enabling selection of areas with highest tracer uptake (vital tissue) for core needle biopsy. Hence, it will be possible to more adequately tailor the individual treatment, also enabling therapy response monitoring. This review evaluates the current and future perspectives as well as the shortcomings of breast imaging using dedicated nuclear medicine devices.

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“…positron emission mammography (PEM) and a tomographic technique using a ring-shaped scanner (ring-shaped dbPET) [7]. PEM systems depict breast tissue via soft compression of the breast with two opposing plate-like detectors and have higher sensitivity than whole-body PET/CT [8][9][10] while ring-shaped dbPET scanners can visualise breast cancer more clearly than whole-body PET/CT [11,12]. These high-resolution breast PET systems have greater photon sensitivity and can improve spatial resolution by setting the detector close to the breast, reducing respiratory movement, and using smaller detection units with reconstruction methods that are different to those used for whole-body PET/CT.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of image quality at the detector’s edge of dedicated breast positron emission tomography: Can small breast cancer near the chest wall be detected ?

Satoh¹,

Imai²,

Omiya³

et al. 2020

Preprint

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Purpose : We assessed image quality of dedicated breast positron emission tomography (dbPET) at the detector's edge by phantom and clinical studies.Methods: A breast phantom with four spheres (16, 10, 7.5, and 5 mm in diameter) was filled with 18 F-fluorodeoxyglucose solution of sphere-to-background ratio was 8:1. It was positioned such that the spheres were five different positions from the top edge to the centre of the detector and scanned for 5 min in each position. Reconstructed images were visually evaluated, and % background variability ( %N 5mm ), % contrast ( %Q H ,5mm ), contrast-to-noise ratio ( Q H ,5mm / N 5mm ), and coefficient of variation of the background ( CV background ) were calculated. Next, tumour-to-background ratios (TBRs) between breast cancer near the chest wall (close to the detector’s edge; peripheral group) and at other locations (non-peripheral group) were compared. The TBR of each lesion was also compared between dbPET and PET/computed tomography (CT).Results: As closer to the detector’s edge, the %N 5mm and CV background increased and %Q H ,5mm and Q H ,5mm / N 5mm decreased in the phantom study. The disadvantages of this placement were visually confirmed. With regard to clinical images, TBR of dbPET was significantly higher than that of PET/CT in both the peripheral (12.1±6.2 vs. 6.5±3.4, p =0.0001) and non-peripheral (13.1±7.1 vs. 7.7±7.4, p =0.0004) groups. There was no significant difference in TBR of dbPET between the peripheral and non-peripheral groups (12.1±6.2 vs. 13.1±7.1, p= 0.6367).Conclusion : In the phantom study, the image quality decreased closer to the detector’s edge than at a depth of 1/8. In clinical studies, however, the lesion detectability of dbPET was the same even if the lesion was close to the detector’s edge or not, and it was higher than that in PET/CT. dbPET has a great potential for detecting breast lesions near the chest wall even in young women with small breasts.

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Diagnostic performance of a novel dedicated breast PET scanner with C-shaped ring detectors

Abstract: There was no significant difference in breast cancer detectability in this population. The C scanner demonstrated ∼1.6-fold larger maximum SUV than WB PET/CT.

Cited by 16 publications

References 23 publications

Dedicated Breast Gamma Camera Imaging and Breast PET

Dedicated Breast Gamma Camera Imaging and Breast PET

Novel frontiers of dedicated molecular imaging in breast cancer diagnosis

Evaluation of image quality at the detector’s edge of dedicated breast positron emission tomography: Can small breast cancer near the chest wall be detected ?

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