Dedicated Breast Gamma Camera Imaging and Breast PET

Narayanan, Deepa; Berg, Wendie A.

doi:10.1016/j.cpet.2018.02.008

Cited by 36 publications

(13 citation statements)

References 91 publications

(103 reference statements)

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“…Molecular imaging of the breast has a long research history, including whole-body PET and PET/CT scanning and dedicated breast SPECT and PET scanning (3). Considering the clinical role of MRI and the difficult co-registration of the highly plastic organ, breast PET/MRI is a particular promising modality that overlays accurate morphologic and functional imaging with molecular markers.…”

mentioning

confidence: 99%

Simultaneous FAPI PET/MRI Targeting the Fibroblast-Activation Protein for Breast Cancer

Backhaus¹,

Burg²,

Roll³

et al. 2022

Radiology

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Integrated PET/MRI is a promising modality for breast assessment. The most frequently used tracer, fluorine 18 ( 18 F) fluorodeoxyglucose (FDG), is applied for whole-body staging in advanced breast cancer but has limited accuracy in evaluating primary breast lesions. The fibroblast-activation protein (FAP) is abundantly expressed in invasive breast cancer. FAP-directed PET tracers have recently become available, but results in primary breast tumors remain lacking.Purpose: To evaluate the use of FAP inhibitor (FAPI) breast PET/MRI in assessing breast lesions and of FAPI whole-body scanning for lymph node (LN) and distant staging using the ligand gallium 68 ( 68 Ga)-FAPI-46. Materials and Methods:In women with histologically confirmed invasive breast cancer, all primary 68 Ga-FAPI-46 breast and wholebody PET/MRI and PET/CT examinations conducted at the authors' center between October 2019 and December 2020 were retrospectively analyzed. MRI lesion characteristics and standardized uptake values (SUVs) were quantified with dedicated software. Mann-Whitney U tests were used to compare tumor SUVs across different tumor types. The Pearson correlation coefficient was calculated between SUV and measures of MRI morphologic characteristics.Results: Nineteen women (mean age, 49 years 6 9 [standard deviation]) were evaluated-18 to complement initial staging and one for restaging after therapy for distant metastases. Strong tracer accumulation was observed in all 18 untreated primary breast malignancies (mean maximum SUV [SUV max ] = 13.9 [range, 7.9-29.9]; median lesion diameter = 26 mm [range, 9-155 mm]), resulting in clear tumor delineation across different gradings, receptors, and histologic types. All preoperatively verified LN metastases in 13 women showed strong tracer accumulation (mean SUV max = 12.2 [range, 3.3-22.4]; mean diameter = 21 mm [range, 14-35 mm]).Tracer uptake established or supported extra-axillary LN involvement in seven women and affected therapy decisions in three women. Conclusion:This retrospective analysis indicates use of 68 Ga fibroblast-activation protein inhibitor tracers for breast cancer diagnosis and staging.

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mentioning

confidence: 99%

Simultaneous FAPI PET/MRI Targeting the Fibroblast-Activation Protein for Breast Cancer

Backhaus¹,

Burg²,

Roll³

et al. 2022

Radiology

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“…It also helps in the assessment of the stage of cancer and improvement in therapy responses. Methods using these techniques include positron emission tomography (PET), scintimammography, positron emission mammography (PEM), and breast specific gamma imaging (BSGI) [38]. Scintimammography was used earlier using MIBI radiopharmaceutical agents which is cationic in nature, along with gamma cameras [39].…”

Section: Radionuclide Methodsmentioning

confidence: 99%

Advanced and futuristic approaches for breast cancer diagnosis

et al. 2020

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Background Breast cancer is the most frequent cancer and one of the most common causes of death in women, impacting almost 2 million women each year. Tenacity or perseverance of breast cancer in women is very high these days with an extensive increasing rate of 3 to 5% every year. Along with hurdles faced during treatment of breast tumor, one of the crucial causes of delay in treatment is invasive and poor diagnostic techniques for breast cancer hence the early diagnosis of breast tumors will help us to improve its management and treatment in the initial stage. Main body Present review aims to explore diagnostic techniques for breast cancer that are currently being used, recent advancements that aids in prior detection and evaluation and are extensively focused on techniques that are going to be future of breast cancer detection with better efficiency and lesser pain to patients so that it helps to a physician to prevent delay in treatment of cancer. Here, we have discussed mammography and its advanced forms that are the need of current era, techniques involving radiation such as radionuclide methods, the potential of nanotechnology by using nanoparticle in breast cancer, and how the new inventions such as breath biopsy, and X-ray diffraction of hair can simply use as a prominent method in breast cancer early and easy detection tool. Conclusion It is observed significantly that advancement in detection techniques is helping in early diagnosis of breast cancer; however, we have to also focus on techniques that will improve the future of cancer diagnosis in like optical imaging and HER2 testing.

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“…In addition, there are currently a large number of ongoing hardware developments driven by the limitations of traditional Whole Body PET (WB-PET) scanners. Examples include high coverage total body PET systems [6] as well as organ specific scanners such as brain dedicated PET [7] and breast dedicated PET [8,9]. Brain dedicated scanners are motivated by the fact that the resolution and sensitivity of conventional WB-PET is not high enough to accurately image small brain structures [7].…”

Section: Introductionmentioning

confidence: 99%

A layered single-side readout depth of interaction time-of-flight-PET detector

et al. 2021

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We are exploring a scintillator-based PET detector with potential of high sensitivity, depth of interaction (DOI) capability, and timing resolution, with single-side readout. Our design combines two previous concepts: (1) multiple scintillator arrays stacked with relative offset, yielding inherent DOI information, but good timing performance has not been demonstrated with conventional light sharing readout. (2) Single crystal array with one-to-one coupling to the photodetector, showing superior timing performance compared to its light sharing counterparts, but lacks DOI. The combination, where the first layer of a staggered design is coupled one-to-one to a photodetector array, may provide both DOI and timing resolution and this concept is here evaluated through light transport simulations. Results show that: (1) unpolished crystal pixels in the staggered configuration yield better performance across all metrics compared to polished pixels, regardless of readout scheme. (2) One-to-one readout of the first layer allows for accurate DOI extraction using a single threshold. The number of multi pixel photon counter (MPPC) pixels with signal amplitudes exceeding the threshold corresponds to the interaction layer. This approach was not possible with conventional light sharing readout. (3) With a threshold of 2 optical photons, the layered approach with one-to-one coupled first layer improves timing close to the MPPC compared to the conventional one-to-one coupling non-DOI detector, due to effectively reduced crystal thickness. Single detector timing resolution values of 91, 127, 151 and 164 ps were observed per layer in the 4-layer design, to be compared to 148 ps for the single array with one-to-one coupling. (4) For the layered design with light sharing readout, timing improves with increased MPPC pixel size due to higher signal per channel. In conclusion, the combination of straightforward DOI determination, good timing performance, and relatively simple design makes the proposed concept promising for DOI-Time-of-Flight PET detectors.

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Dedicated Breast Gamma Camera Imaging and Breast PET

Cited by 36 publications

References 91 publications

Simultaneous FAPI PET/MRI Targeting the Fibroblast-Activation Protein for Breast Cancer

Simultaneous FAPI PET/MRI Targeting the Fibroblast-Activation Protein for Breast Cancer

Advanced and futuristic approaches for breast cancer diagnosis

A layered single-side readout depth of interaction time-of-flight-PET detector

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