Diagnostic performance of 18F-FDG PET-CT for large vessel involvement assessment in patients with suspected giant cell arteritis and negative temporal artery biopsy

Hay, Boramy; Mariano‐Goulart, Denis; Bourdon, A.; Benkiran, Meriem; Vauchot, Fabien; Verbizier, Delphine de; Bouallègue, Fayçal Ben

doi:10.1007/s12149-019-01358-5

Cited by 33 publications

(36 citation statements)

References 30 publications

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“…Indeed, 18 F-FDG uptake by large vessels yielded a sensitivity of 61 per cent, a specificity of 80 per cent, and a diagnostic accuracy of 73 per cent. 116 This reinforces that the diagnosis of TA measured by PET-CT does not preclude the necessity of TA biopsy. In addition, it is recognised by nuclear medicine units in Sydney, Australia, that the inflammation in affected arteries may resolve within three days of commencing corticosteroid therapy.…”

Section: Surgical Biopsy and Histopathology Of The Temporal Arterysupporting

confidence: 59%

The diagnosis and management of temporal arteritis

Ling

Yosar

Lee

et al. 2020

Clinical and Experimental Optometry

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Temporal arteritis (TA), or giant cell arteritis, is a systemic autoimmune vasculitis affecting patients over 50 years of age. It can cause rapid, irreversible bilateral vision loss in older adults and is therefore considered an ophthalmological emergency. Many of the symptoms and signs of TA can be vague, non‐specific and gradual in onset, often leading to a delayed or inaccurate diagnosis. As such, it is important for a wide variety of primary optometrists and health practitioners to maintain a robust understanding of the clinical presentation, key investigations and time‐sensitive management of this disease, as early initiation of treatment for TA can be vision‐ and life‐saving.

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Section: Surgical Biopsy and Histopathology Of The Temporal Arterysupporting

confidence: 59%

The diagnosis and management of temporal arteritis

Ling

Yosar

Lee

et al. 2020

Clinical and Experimental Optometry

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“…In a recent study of 64 newly suspected GCA patients, the sensitivity and specificity of PET/CT were 92% and 85%, respectively, compared with TAB, with a high negative predictive value [26,46]. A recent retrospective study evaluated the diagnostic performance of 18-FDG PET-CT for large vessel involvement in patients with suspected GCA and negative TAB [47]. In these 63 patients, 18F-FDG PET-CT showed large vessel involvement in 22 patients, 14 of whom were finally diagnosed with GCA and 41 patients were 18F-FDG PET-CT negative and nine were diagnosed with GCA.…”

Section: -Fdg Positron Emission Tomography In Giant Cell Arteritismentioning

confidence: 99%

Imaging for Diagnosis, Monitoring, and Outcome Prediction of Large Vessel Vasculitides

2020

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Purpose of Review To discuss and summarize the latest evidence on imaging techniques in giant cell arteritis (GCA) and Takayasu arteritis (TAK). This is a report on the performance of ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT), 18F-fluorodeoxyglucose positron emission tomography (18-FDG-PET), and other emerging imaging techniques in diagnosis, outcome prediction, and monitoring of disease activity. Recent Findings Imaging techniques have gained an important role for diagnosis of large vessel vasculitides (LVV). As signs of vasculitis, US, MRI, and CT show a homogeneous arterial wall thickening, which is mostly concentric. PET displays increased FDG uptake in inflamed artery walls. US is recommended as the initial imaging modality in GCA. MRI and PET/CT may also detect vasculitis of temporal arteries. For TAK, MRI is recommended as the first imaging modality as it provides a good overview without radiation. Extracranial LVV can be confirmed by all four modalities. In addition, MRI and PET/CT provide consistent examination of the aorta and its branches. New techniques such as contrast-enhanced ultrasound, PET/MRI, and auxiliary methods such as “computer-assisted quantitative analysis” have emerged and need to be further validated. Summary Imaging has partly replaced histology for confirming LVV. Provided experience and adequate training, US, MRI, CT, or PET provide excellent diagnostic accuracy. Imaging results need to complement history and clinical examination. Ongoing studies are evaluating the role of imaging for monitoring and outcome measurement.

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“…CT or magnetic resonance angiography is useful in delineating the vascular wall abnormalities, but they do not indicate disease activity, as does FDG-PET/CT 3. The latter is also useful in multiterritorial or occult disease 4. In a recent meta-analysis, hypoechoic halo on TA ultrasound is shown to have better sensitivity than biopsy,5 and when used concomitantly, it can add significantly to the diagnostic yield 6.…”

Section: Descriptionmentioning

confidence: 99%