Diagnostic performance and clinical application of preoperative COVID-19 bedside testing with ID NOW™

Diagnostic accuracy of the Abbott ID NOW SARS-CoV-2 rapid test for the triage of acute medical admissions

“…Tu et al evaluated 974 patients in an outpatient clinic setting and found a prevalence of 2.4%, positive percentage agreement (PPA) 91.3% and negative percentage agreement (NPA) 100%, with only two false negatives, with Ct values of 36.5 and 38.1 [ 17 ]. Another large cohort taken from asymptomatic pre-operative outpatient screening found four cases in 1100 screened (prevalence 0.36%) with an excellent NPA of 99.7% [ 30 ].…”

Update of European Society of Clinical Microbiology and Infectious Diseases coronavirus disease 2019 guidelines: diagnostic testing for severe acute respiratory syndrome coronavirus 2

“… In asymptomatic people, we suggest the use of laboratory-based NAAT in nasopharyngeal samples versus rapid antigen testing in nasopharyngeal samples for the diagnosis of COVID-19. Weak against Low [ 11 , 18 , 38 , 43 , 44 , 46 , 47 , 49 , 50 , [54] , [55] , [56] , 20 , 57 , 65 , 67 , 68 , 70 , 71 , 77 , 81 , 83 , 86 , 22 , 87 , 90 , 92 , 94 , 99 , 102 , 113 , 155 , 158 , 160 , 24 , [161] , [162] , [163] , 165 , 168 , 170 , [172] , [173] , [174] , [175] , 28 , [176] , [177] , [178] , [179] , [180] , [181] , [182] , [183] , [29] , [30] ...…”

Cas12a-assisted RTF-EXPAR for accurate, rapid and simple detection of SARS-CoV-2 RNA

“…They have been established for SARS-CoV-2 diagnosis outside of complex laboratories and can produce rapid results (<1 h) ( Dao Thi et al, 2020 ; Feng et al, 2021 ; Pang et al, 2020 ; Xia and Chen, 2020 ). Another typical test in this category is Abbott's ID NOW COVID-19 which can obtain positive results within 5 min and negative results in 13 min based on a nicking endonuclease isothermal amplification reaction (NEAR) ( Tauh et al, 2021 ; Tu et al, 2021 ). Notably, Carter et al recently described a new isothermal method (called RTF-EXPAR) by combining exponential amplification reaction (EXPAR) with reverse transcription-free (RTF) step to convert RNA to DNA to achieve indirectly detection of the Orf1ab gene, allowing complete test within 10 min ( Carter et al, 2021 ).…”