Abstract:This clinical study was conducted to evaluate the diagnostic value of C‐reactive protein (CRP), interlekin‐6 (IL‐6) and immunoglobulin M (IgM) in the early diagnosis of neonatal sepsis. The diagnostic values of each marker separately or in combinations were evaluated. The optimal cut‐off values of each marker in the diagnosis of neonatal sepsis were defined. Between December 2004 and March 2005, a total of 78 neonates at different ages with different diagnoses in a neonatal intensive care unit in North Jordan … Show more
“…In sepsis proven cases, 28(73.7%) were males. Similar findings as elicited in our study were cited by Mohammad f. Ibraheem [16] ,M Khassawne et al [17] stating male infants are more likely to develop sepsis than females. Gestational age: In present study, 92.1 % of the cases of sepsis proven and 82.3% of sepsis probable cases had full term as gestational age.…”
“…In sepsis proven cases, 28(73.7%) were males. Similar findings as elicited in our study were cited by Mohammad f. Ibraheem [16] ,M Khassawne et al [17] stating male infants are more likely to develop sepsis than females. Gestational age: In present study, 92.1 % of the cases of sepsis proven and 82.3% of sepsis probable cases had full term as gestational age.…”
“…Khassawneh M et al [20] reported that a CRP level >4 mg/L gave the best derived cutoff value with 95.7% sensitivity, 88.9% specificity, 78.6% PPV, and 98% NPV.…”
Section: Late-onset Neonatal Sepsis (Los) Is a Life-threatening Condimentioning
Background:-Sepsis is a common cause of morbidity and mortality among neonates, and current biomarkers for diagnosis are not adequate. The objective of the study was to assess the diagnostic and prognostic value of presepsin.Methods:-One hundred and twenty neonates were enrolled in the study; 80 cases and 40 controls. Presepsin and CRP levels were measured during 1st, 2nd& 6th days of admission for cases while were measured once for each control.Results:-Initial presepsin levels were significantly higher in group produced neonatal sepsis than in the non-septic group. At a cut off value ≥ 0.722 µg/L, Presepsin sensitivity for prediction of neonatal sepsis was 100 %, specificity 97.5%, positive predictive value (PPV) 98.7%, negative predictive value (NPV) 100%, area under curve (AUC) 0.99 with high sensitive positive correlation with sepsis (P value < 0.001). At a cut off value < 2.3 µg/L, Its prognostic sensitivity was 75.9%, specificity 72.5%, PPV 61.1, NPV 84.1 and AUC 0.76. Conclusion:-Presepsin sensitivity for early diagnosis of neonatal sepsis was 100 % with specificity 97.5%. Presepsin is an accurate biomarker for early diagnosis of neonatal sepsis. It also provides a useful tool for prediction of improving.Copy Right, IJAR, 2016,. All rights reserved.
“…Several acute-phase reactants such as C-reactive protein (CRP) and interleukin-6 (IL-6) have proven helpful in the diagnosis of an ongoing infection. However, the rate at which each marker begins to show elevations and the time to normalization differs with each marker (3)(4)(5)(6)(7).…”
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