Proadrenomedullin as a prognostic marker in neonatal sepsis

Öncel, Mehmet Yekta; Dilmen, Uğur; Erdeve, Ömer; Оздемир, Рамазан; Çalışıcı, Erhan; Yurttutan, Sadık; Canpolat, Fuat Emre; Oğuz, Şerife Suna; Uraş, Nurdan

doi:10.1038/pr.2012.106

Cited by 39 publications

(39 citation statements)

References 25 publications

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“…In this letter, the authors consider that the lack of usefulness of pro-adrenomedullin as diagnostic tool for detecting severe bacterial infection in febrile infants found in our study [1] may be mainly due to the time profile of this biomarker. In contrast to our results, they found proadrenomedullin very useful in the early detection of neonatal sepsis [2] and so they suggest that this biomarker could be only useful in the close follow-up of hospitalized patients.…”

contrasting

confidence: 99%

Reply to correspondence letter: Is pro-adrenomedullin more useful marker in hospitalized infants with sepsis?

Benito

2013

Eur J Pediatr

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contrasting

confidence: 99%

Reply to correspondence letter: Is pro-adrenomedullin more useful marker in hospitalized infants with sepsis?

Benito

2013

Eur J Pediatr

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“…Equine sepsis increases observed in septic patients (Ueda et al 1999;Gibbons et al 2007;Oncel et al 2012). Although AM has not been evaluated in adult horses, a recent study investigated plasma AM concentration in 3 groups of neonatal foals: septic, sick nonseptic and healthy controls (Toth et al 2014).…”

mentioning

confidence: 99%

A review of equine sepsis

Taylor

2015

Equine Veterinary Education

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Summary Sepsis is defined as an exaggerated, systemic inflammatory response to infection and is a common condition in horses. Systemic inflammatory response syndrome (SIRS) associated with bacterial infection is a hallmark of sepsis. Sepsis in neonatal foals is a common sequela of failure of passive transfer and, in addition to development of SIRS, may be characterised by bacteraemia, pneumonia, enterocolitis, omphalophlebitis, meningoencephalitis or arthritis. Sepsis in mature horses is most commonly observed secondary to gastrointestinal lesions that result in disrupted mucosa and bacterial translocation into circulation (endotoxaemia). Pleuropneumonia and metritis may also cause sepsis in mature horses. Diagnosis of sepsis is based on SIRS criteria as well as suspected or confirmed infection. Due to the relatively low sensitivity of microbial culture and the subjectivity of sepsis scoring, many sepsis biomarkers are being studied for their usefulness in diagnosis and prognostication of sepsis in horses. Treatment of sepsis requires an intensive care approach that includes antimicrobial drug administration, fluid resuscitation and pressure support, and treatment for inflammation, endotoxaemia and coagulopathy. Early recognition of sepsis and prompt antimicrobial drug treatment are critical for a successful outcome. Multiple organ dysfunction syndrome may occur in severe cases of sepsis, with common manifestations including laminitis and coagulopathies. Although prognosis for septic mature horses depends highly on the primary disease process, the overall survival rate in septic neonatal foals ranges from 26 to 86%, with most studies indicating a survival rate of 45–60%.

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“…There exists a substantial observational literature regarding ProADM use as an all-cause mortality predictor in patients with sepsis [11][12][13][14][15][16][17][18][19], in patients with a variety of underlying diseases presenting to the emergency department (ED) with acute dyspnea [20][21][22][23][24][25][26], and especially in patients with community-acquired pneumonia (CAP) [13,[27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

The prognostic blood biomarker proadrenomedullin for outcome prediction in patients with chronic obstructive pulmonary disease (COPD): a qualitative clinical review

Schuetz¹,

Marlowe²,

Müeller

2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Plasma proadrenomedullin (ProADM) is a blood biomarker that may aid in multidimensional risk assessment of patients with chronic obstructive pulmonary disease (COPD). Co-secreted 1:1 with adrenomedullin (ADM), ProADM is a less biologically active, more chemically stable surrogate for this pluripotent regulatory peptide, which due to biological and ex vivo physical characteristics is difficult to reliably directly quantify. Upregulated by hypoxia, inflammatory cytokines, bacterial products, and shear stress and expressed widely in pulmonary cells and ubiquitously throughout the body, ADM exerts or mediates vasodilatory, natriuretic, diuretic, antioxidative, anti-inflammatory, antimicrobial, and metabolic effects. Observational data from four separate studies totaling 1366 patients suggest that as a single factor, ProADM is a significant independent, and accurate, long-term allcause mortality predictor in COPD. This body of work also suggests that combined with different groups of demographic/clinical variables, ProADM provides significant incremental long-term mortality prediction power relative to the groups of variables alone. Additionally, the literature contains indications that ProADM may be a global cardiopulmonary stress marker, potentially supplying prognostic information when cardiopulmonary exercise testing results such as 6-min walk distance are unavailable due to time or other resource constraints or to a patient's advanced disease. Prospective, randomized, controlled interventional studies are needed to demonstrate whether ProADM use in risk-based guidance of site-of-care, monitoring, and treatment decisions improves clinical, qualityof-life, or pharmacoeconomic outcomes in patients with COPD.

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Proadrenomedullin as a prognostic marker in neonatal sepsis

Cited by 39 publications

References 25 publications

Reply to correspondence letter: Is pro-adrenomedullin more useful marker in hospitalized infants with sepsis?

Reply to correspondence letter: Is pro-adrenomedullin more useful marker in hospitalized infants with sepsis?

A review of equine sepsis

The prognostic blood biomarker proadrenomedullin for outcome prediction in patients with chronic obstructive pulmonary disease (COPD): a qualitative clinical review

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