Diagnostic Laparotomy and Splenectomy for Staging Hodgkin's Disease

Lowenbraun, Stanley; Ramsey, Harold E.; Sutherland, John M.; Serpick, Arthur A.

doi:10.7326/0003-4819-72-5-655

Cited by 58 publications

(5 citation statements)

References 5 publications

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“…Splenectomy-therupuetic: In addition to removing a possible focus of disease, splenectomy helps patients tolerate subsequent radiotherapy and chemotherapy much better. We have seen this in our group of patients, as has been noted by others (Glatstein et al, 1969;Lowenbraun et al, 1970;Nies and Creger, 1967).…”

Section: Discussionsupporting

confidence: 89%

“…The usefulness of laparotomy and splenectomy in the staging of Hodgkin's Disease has been emphasized by others (Glatstein et al, 1969;Lowenbraun et al, 1970;Rosenberg and Kaplan, 1970) and is borne out in our series of a primarily unselected group, although a mixed population of treated and "virgin" cases.…”

Section: Discussionmentioning

confidence: 65%

“…Primary splenic involvement with Hodgkin's Disease is extremely rare; however, secondarily it is involved in 30% of the cases initially and about 80% in the late stages of the disease (Craver, 1964;Healy et al, 1955;Jackson and Parker, 1947). Once the spleen is involved, this becomes a Stage 111 (or IV if the liver is also involved) and as observed by us and by others (Glatstein et al, 1969;Lowenbraun et al, 1970) the only way to find out if the spleen is involved is with a meticulous histologic examination of the spleen. Thus splenectomy helps in the diagnosis to see if there is splenic involvement and therefore for staging of the disease.…”

Section: Discussionmentioning

confidence: 77%

“…In order to achieve this goal, various investigative procedures are used to outline the extent of involvement so that every focus of involvement can be eradicated. Because of the limitations of lymphangiography and the clinical evaluation of the liver and spleen, diagnostic laparotomy and splenectomy has been undertaken at several centers-Stanford (Glatstein et al, 1969;Kadin et al, 1971;Kaplan, 1968;Rosenberg and Kaplan, 1970) and others (Lowenbraun et al, 1970). Our experience with these procedures at the Rhode Island Hospital is presented.…”

Section: Introductionmentioning

confidence: 99%

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Laparotomy and splenectomy in Hodgkin's disease—diagnostic, preventive and therapeutic

Rege

Soderberg

Resnevic

et al. 1972

Journal of Surgical Oncology

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Thirty primarily unselected but a mixed population of ‘virgin’ and treated patients with a diagnosis of Hodgkin's Disease were subjected to diagnostic laparotomy, splenectomy, liver biopsy, and para‐aortic lymph node biopsy as part of their evaluation for the purpose of staging the disease. The post‐operative pathologic findings were correlated with the preoperative clinical evaluation. Preoperative evaluation of abdominal lymph nodes, spleen, and liver was inaccurate in 3/25 (12%), 9/30 (30%), and 5/30 (17%) patients, respectively, with the result that there was a change in the post‐operative staging in eleven (37%) patients. No instance of liver involvement by Hodgkin's Disease was noted without concomitant splenic involvement. Also, there was no instance of splenic involvement without a concomitant para‐aortic lymph node involvement. These findings suggest a possible spread of the disease to the spleen via the abdominal lymph nodes and to the liver via the spleen. It is concluded that laparotomy with splenectomy is a valuable procedure for diagnostic delineation of intra‐abdominal disease but in addition has therapeutic and preventive implications.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Laparotomy and splenectomy in Hodgkin's disease—diagnostic, preventive and therapeutic

Rege

Soderberg

Resnevic

et al. 1972

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…In the past two years laparotomy and splenectomy have been widely accepted as helpful tools. In the literature and in our experience the results of microscopical examination of the spleen have not always been what were expected preoperatively (Glatstein et al, 1969;Lowenbraun et al, 1970). Furthermore, in some of these cases the abnormal histological appearances of the spleen could hardly be explained on the basis of lymphatic spread from a unicentric focus (Rosenberg, 1966;Rosenberg and Kaplan, 1966).…”

mentioning

confidence: 78%