Observations on Abnormal Cells in the Peripheral Blood and Spleen in Hodgkin's Disease

Halie, M. R.; Eibergen, R; Nieweg, H. O.

doi:10.1136/bmj.2.5814.609

Cited by 26 publications

(8 citation statements)

References 8 publications

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“…Pathologic examination revealed the nodular sclerosis type of Hodgkin's disease. He was staged CSIAPSIs-h-n-m- [1], Examination of peripheral blood leukocyte concentrates and spleen histology led to the assignment into the localized form [3]. Head and neck, mediastinal and axillary glands were irradiated in a single so-called mantle field (Cobald, 4,000 rad in 38 days).…”

Section: Case Reportmentioning

confidence: 99%

Infectious Mononucleosis in a Patient with Hodgkin’s Disease

Langenhuysen¹

1976

Acta Haematol

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Section: Case Reportmentioning

confidence: 99%

Infectious Mononucleosis in a Patient with Hodgkin’s Disease

Langenhuysen¹

1976

Acta Haematol

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“…T h e 16% incidence found by us with counterelectrophoresis paralleled the 10y0 and 21% Australia antibody positive sera in healthy adults and volunteer blood donors, detected by the highly sensitive radioimmunoassay and reported by others. 6 Elevation of antibody to both CMV and EBV cast some doubt on a specific role of EBV in Hodgkin's disease. T h e possibility cannot be excluded, however, that a virus could trigger the disease process in an individual case.…”

mentioning

confidence: 99%

Antibodies to epstein-barr virus, cytomegalovirus, and australia antigen in hodgkin's disease

Langenhuysen

Cazemier

Houwen

et al. 1974

Cancer

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Antibodies to Epstein‐Barr virus and cytomegalovirus, determined by an indirect immunofluorescence technique, were found to be significantly elevated in sera of untreated patients with Hodgkin's disease, as opposed to sera of age‐ and sex‐matched healthy controls. Significantly higher titers were also found in subgroups with clinically advanced disease. This pattern did not hold for histologic subclasses, as significant antibody elevations occurred only in the prognostically favorable types. Australia antibody was demonstrated by counter‐electrophoresis in four patients but in none of the controls. The prevalence of the various antibodies might be explained by a humoral hyper‐reactivity secondary to a cellular immunologic deficiency. The results presented cast some doubt on a specific role of Epstein‐Barr virus in Hodgkin's disease.

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“…The presence of pruritus alone is no longer thought to justify sub-classification B . Halie, Eibergen and Nieweg (1972a) found in a study of peripheral blood leucocyte com;entrates that patients with disease in the spleen have a high incidence of abnormal large blast-like cells in the peripheral blood. This was interpreted as supporting haematogenolls spread or multicentric origin.…”

Section: Slagingmentioning

confidence: 99%