Diagnostic investigations in 101 dogs with pyrexia of unknown origin

Dunn, Katie; Dunn, J. K.

doi:10.1111/j.1748-5827.1998.tb03711.x

Cited by 38 publications

(75 citation statements)

References 7 publications

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“…IPA is diagnosed when radiographic abnormalities are absent and the synovial fluid examination is indicative of inflammation, and after the exclusion of other types of inflammatory joint diseases. Due to the lack of specific laboratory tests and its vague symptoms, IPA is sometimes difficult to diagnose and is known to be the most common cause of fever of undetermined origin [8].…”

mentioning

confidence: 99%

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Ohno

Yokoyama

Nakashima

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. To investigate the clinical utility of C-reactive protein (CRP) in idiopathic polyarthritis (IPA), its concentration was measured in dogs with IPA. The CRP concentration was markedly increased in all the IPA dogs at the time of diagnosis and decreased significantly in response to the initial corticosteroid treatment; this indicated that CRP can be used as an index for therapeutic response in IPA cases. Furthermore, at 6 months after the diagnosis, a significant association was observed between the CRP concentration at follow-up (6-13 days after the treatment was started) and the frequency of medication ("no or seldom-medicated (NSM)" groups or "continuing medication (CM)" groups). These results suggest that the initial response of CRP to corticosteroid treatment may be a prognostic factor of canine IPA. KEY WORDS: canine, C-reactive protein, idiopathic polyarthritis.

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confidence: 99%

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Ohno

Yokoyama

Nakashima

et al. 2006

The Journal of Veterinary Medical Science

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“…Pyrexia of unknown origin in dogs has been defined as a disease that, in addition to the definitions for human disease, features body temperatures of over 40 °C (Dunn and Dunn 1998). In the current study, immune-mediated disease was defined as cases that displayed high levels of CRP in accordance with the specifications of Bohnhorst et al (2002).…”

Section: Discussionmentioning

confidence: 99%

“…Dunn and Dunn (1998) examined 101 dogs presenting with pyrexia of unknown origin, and reported the causes to fall into six different groups, infection (16%), tumours (9.5%), immune system (22%), other diseases (11.5%), primary marrow disease (22%) and unknown (19%). However, large-scale investigations into the levels of RF and ANA in dogs have not yet been conducted.…”

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confidence: 99%

Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs

Tamura¹,

Nagashima²,

Oda³

et al. 2012

Vet. Med. - Czech

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ABSTRACT:The levels of rheumatoid factor (RF), antinuclear antibody (ANA), and composition of peripheral lymphocyte subsets in 515 dogs were examined. Of these sample cases, 33 cases were diagnosed as immune-mediated fever that presented with high C-reactive protein (CRP), 31 cases were diagnosed with Hansen's Type 1 disc herniation and the remaining 415 cases were clinically healthy dogs, and served as controls. In the cases diagnosed with immune-mediated fever, 84% of the dogs tested positive to either RF or ANA (RF positive 60.6%; ANA positive 24.2%). By contrast, 16.2% of the healthy dogs were positive for either RF or ANA (RF positive 14.9%; ANA 1.3%). The CD4/CD8 ratio for peripheral lymphocyte was high for all analysed cases diagnosed with immune-mediated fever, and was significantly higher than those of healthy controls. These results indicate that the abnormal levels of lymphocytes may be an effective indicator for immune-mediated disease coupled to immune-mediated fever.

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“…Η ευρεία διακύμανση της συχνότητας συμμετοχής τους στην αιτιολογία του ΠΑΠ στις διάφορες μελέτες εξαρτάται από το διαφορετικό προσανατολισμό εξειδίκευσης της αντίστοιχης ερευ νητικής ομάδας (Limn 2001, Miller 2005) και από την ενδημικότητά τους στην περιοχή διεξαγωγής της έ ρευνας. Πάντως, είναι κοινά αποδεκτό πως οι λοιμώ δεις παράγοντες ευθύνονται συχνότερα (16%-47%) για την πρόκληση του ΠΑΠ στο σκΰλο (Bennett 1995, Dunn andDunn 1998) και επιβάλλεται να προτάσσεται η διαγνωστική τους διερεύνηση (Couto 2003).…”

Section: αιτιολογίαunclassified

“…Τα νοσήματα ανοσολογικής αιτιολογίας έπονται των λοιμωδών με μικρή μόνο διαφορά στη συχνότητα εμφάνισης τους (22%-40%) (Bennett 1995, Dunn andDunn 1998) (Πίνακας 1) (Couto 2003). Για τον πυρε τό, που είναι ιδιαίτερα υψηλός στα νοσήματα αυτά, ευθύνονται τα ανοσοσΰμπλοκα (Miller 2005).…”

Section: αιτιολογίαunclassified

Fever of unknown origin in the dog

Pardali

Adαmama-Moraitou

Rallis

2017

J Hellenic Vet Med Soc

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Fever of unknown origin (FUO) refers to a febrile syndrome that does not resolve spontaneously in an adequate period of time for the remission of self-limited infections and definitive diagnosis cannot be established despite considerable diagnostic effort. This definition is an extrapolation from human medicine, since FUO has not been still defined accurately in animals. The spectrum of diseases involved in FUO includes infectious, neoplastic, immune-mediated, miscellaneous and not defined diseases. Clients and clinicians must be aware that FUO may be a diagnostic challenge. The diagnostic plan should always begin with costless and simple tests followed by more invasive and expensive procedures. The initial diagnostic approach of FUO includes a detailed history, a thorough physical examination, a routine laboratory evaluation and radiographical examination of the thorax and abdomen. If diagnosis cannot be achieved, specific non-invasive tests should then be applied. No therapeutic trial should be initiated during evaluation, since it may alleviate clinical symptoms and alter the laboratory results potentially misleading the diagnostic approach. Nevertheless, fever is rarely harmful. In body temperature above 41,0 °C, diagnostic evaluation is postponed and the initiation of an emergency therapy is strongly recommended. If definitive diagnosis is confirmed, the dog is treated accordingly. Therapeutic trial is indicated, if despite the thorough evaluation no diagnosis is established or the owners are unwilling to support the cost of the diagnostic work-up of their dog. Therapy is focused on the administration of antibiotics followed by steroids and finally non-steroid anti-inflammatory drugs.

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Diagnostic investigations in 101 dogs with pyrexia of unknown origin

Cited by 38 publications

References 7 publications

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs

Fever of unknown origin in the dog

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