C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Ohno, Koichi; Yokoyama, Yasushi; Nakashima, Ko; Setoguchi, Asuka; Fujino, Yasuhito; Tsujimoto, Hajime

doi:10.1292/jvms.68.1275

Cited by 58 publications

(69 citation statements)

References 18 publications

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“…Recent investigations into canine CRP levels have reported elevated levels in a number of disease states including irritable bowel syndrome (IBD) (Jergens et al 2003) and autoimmune haemolytic anaemia (AIHA) (Tecles et al 2005). A marked increase in CRP levels was noted in all of the canine immunemediated arthritis cases analysed in a recent study (Ohno et al 2006). A high level was also observed in this study with an average of 6.9 ± 6.7%.…”

Section: Discussionsupporting

confidence: 62%

Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs

Tamura¹,

Nagashima²,

Oda³

et al. 2012

Vet. Med. - Czech

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ABSTRACT:The levels of rheumatoid factor (RF), antinuclear antibody (ANA), and composition of peripheral lymphocyte subsets in 515 dogs were examined. Of these sample cases, 33 cases were diagnosed as immune-mediated fever that presented with high C-reactive protein (CRP), 31 cases were diagnosed with Hansen's Type 1 disc herniation and the remaining 415 cases were clinically healthy dogs, and served as controls. In the cases diagnosed with immune-mediated fever, 84% of the dogs tested positive to either RF or ANA (RF positive 60.6%; ANA positive 24.2%). By contrast, 16.2% of the healthy dogs were positive for either RF or ANA (RF positive 14.9%; ANA 1.3%). The CD4/CD8 ratio for peripheral lymphocyte was high for all analysed cases diagnosed with immune-mediated fever, and was significantly higher than those of healthy controls. These results indicate that the abnormal levels of lymphocytes may be an effective indicator for immune-mediated disease coupled to immune-mediated fever.

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Section: Discussionsupporting

confidence: 62%

Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs

Tamura¹,

Nagashima²,

Oda³

et al. 2012

Vet. Med. - Czech

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“…In human medicine, CRP has been reported to indicate the severity and prognosis of various diseases [9,10,16,17]. In veterinary medicine, it has been reported to indicate the response to treatment and prognosis in idiopathic polyarthritis [14]. Further studies are needed to examine the variation in the CRP concentration during clinical courses and to evaluate its relationship with disease severity in order to determine its potential as a prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

“…In Japan, a laser nephelometric immunoassay (LNIA), for canine CRP, was developed in 1998 [13,14] and is now commercially available. In this assay, CRP and anti-canine CRP antiserum are mixed in a specific buffer, exposed to a laser beam, and the scattered light is then measured.…”

mentioning

confidence: 99%

C-Reactive Protein Concentration in Dogs with Various Diseases

Nakamura

Takahashi

Ohno

et al. 2008

The Journal of Veterinary Medical Science

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149

186

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ABSTRACT. To investigate the clinical utility of C-reactive protein (CRP) determination in dogs, its plasma concentration was measured by a laser nephelometric method in 928 dogs with various diseases, and was compared with other inflammatory parameters. CRP concentration was elevated in various inflammatory diseases, this was most frequently observed in cases with neoplastic and immune-mediated diseases. All cases of pyometra, panniculitis, acute pancreatitis, polyarthritis, and hemangiosarcoma showed significantly elevated CRP concentrations. On the other hand, the CRP concentration was elevated only in few cases of neurological diseases such as epilepsy, meningoencephalitis, and hydrocephalus and endocrine diseases such as hypothyroidism, hyperadrenocorticism, and diabetes mellitus. Only a weak correlation was observed between the CRP concentration and white blood cell (WBC) counts (r=0.44) but no correlation with band neutrophil counts. There was no correlation between the CRP and albumin concentrations, but a weak negative correlation (r=-0.40) when excluding chronic intestinal diseases and nephrotic syndrome, which can cause protein loss. Thus, CRP can be useful to detect inflammations that cannot be detected by WBC and, or band neutrophil counts, suggesting that the examination of CRP concentration is essential as routine diagnostic test. KEY WORDS: albumin, C-reactive protein (CRP), canine, neutrophil, WBC.

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“…In the current study, although serum CRP concentration was elevated on presentation in 21 out of 32 dogs, a single CRP determination did not facilitate prediction of outcome, a finding that has been previously reported in dogs with various inflammatory conditions. 3,7,8,12,13,21 Only 3 out of the 28 dogs that had serial CRP concentrations died. Figure 1 suggests that average initial CRP concentrations are predicative of survival.…”

Section: Discussionmentioning

confidence: 99%

“…Although CRP response can vary dramatically in different individuals with the same disease process at presentation, evaluating sequential measurements and degree of decrease in serum CRP concentrations may provide more useful information than a single CRP value. Generally, serum CRP concentrations in dogs with inflammatory bowel disease, 10 immune-mediated polyarthritis, 11,21 and immune-mediated hemolytic anemia 7,16 decrease as clinical signs and leukocytosis resolve in response to therapy. Excluding dogs that were euthanized or died soon after initial CRP analysis in the current study, 88% of dogs with elevated CRP values at presentation had decreases in CRP concentrations by 48-72 hr.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein as a Prognostic Indicator in Dogs with Acute Abdomen Syndrome

et al. 2010

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Abstract. The objective of the present study was to measure serum C-reactive protein (CRP) concentrations in 32 dogs with acute abdomen syndrome at presentation and after 48-72 hr. Data were evaluated to determine if there was an association between CRP concentration and outcome, and if CRP concentration correlated with the white blood cell (WBC) count at both time points. An immunoturbidimetric assay for human CRP, previously validated for use in dogs, was used for serum CRP analysis. Increased serum CRP concentrations were found in 21 dogs at presentation. Fifteen of these dogs had declining serum CRP concentrations by 48-72 hr, but 3 of the 15 dogs were later euthanized. Serum CRP concentrations increased by 48-72 hr in 4 dogs. Of the 32 dogs, 4 were dead or were euthanized prior to the 48-72 hr time point. No significant difference between initial CRP concentration and outcome was found (P 5 0.054). Initial and 48-72 hr CRP values taken together were significantly different between outcome groups (P , 0.001). Serum CRP concentrations that were elevated at both time points were associated with a poor prognosis. No correlation was found between CRP concentrations and WBC counts at presentation (P 5 0.83); however, a significant correlation was noted at 48-72 hr (P 5 0.03). Evaluation of sequential CRP concentrations in dogs with acute abdomen syndrome may be helpful in assessing clinical response to treatment and predicting outcome. Also, serum CRP may be better in detecting tissue injury and/or inflammation at presentation than WBC counts in select cases.

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C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Cited by 58 publications

References 18 publications

Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs

Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs

C-Reactive Protein Concentration in Dogs with Various Diseases

C-Reactive Protein as a Prognostic Indicator in Dogs with Acute Abdomen Syndrome

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