Diagnostic Intraocular Fine-Needle Aspiration Biopsy?An Experience in Three Cases of Retinoblastoma

Sen, Seema; Singha, Ujwala; Kumar, Harsh; Ghose, Supriyo; Sarkar, T. K.; Bajaj, Mandeep S

doi:10.1002/(sici)1097-0339(199911)21:5<331::aid-dc7>3.0.co;2-k

Cited by 12 publications

(5 citation statements)

References 9 publications

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“…Intra ocular fine needle aspiration (FNAB) cytology under general anesthesia can be a viable option in making a diagnosis of retinoblastoma in selected cases. [35] Ratios of aqueous to plasma lactate dehydrogenase enzyme is high in eyes with retinoblastoma. [2] The technique is minimally invasive.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological pattern and management of retinoblastoma in Kano, Nigeria

Abdu

Malami

2011

Ann Afr Med

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Background:The aim of the study is to evaluate the pattern of presentation and the mode of management of retinoblastoma seen in Aminu Kano Teaching Hospital, Kano from 2001 to 2005. Materials and Methods: The clinic register was used to obtain the case folders of all children treated for retinoblastoma and this was used to obtain information on patient's age, sex, and clinical sign(s) at presentation such as orbital mass, leucocoria, proptosis, hyphaema without history of trauma, unexplained hypopyon, or uveitis. Also documented were X ray/B mode ultrasound scan fi ndings, type of surgery performed, histological diagnosis, and adjuvant chemotherapy where applicable. Results: Forty-two patients were reviewed, 15 males and 27 females (M: F = 1.0: 1.8). The age ranged between 2 and 6 years and the peak age of presentation was 3 years in 22 patients (52%). The tumor was unilateral in 40 patients (95%) and bilateral in 2 patients (5%). Most of the patients (46%) presented late with fungating orbital mass. Other signs include leucocoria 22%, proptosis 19%, hyphema 7%, Hypopyon 2%, squint 2%, and buphthalmos 2%. Thirty-one patients (74%) had exenteration and enucleation was performed in 11 patients (26%). The tumor was histologically confi rmed in 41 patients (98%) and was poorly differentiated in 23 patients (55%), 1 patient (2%) had toxocara granuloma. Thirty-nine patients required adjuvant chemotherapy and only 2 received 6 (full) courses. Conclusion: Retinoblastoma, a treatable tumor is characterized by late presentation as illustrated in our study. There is need to create public awareness and educate mothers on this tumor so that there is early diagnosis, appropriate referral, and prompt treatment. The goal is to increase number of children successfully cured of this disease in our environment.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological pattern and management of retinoblastoma in Kano, Nigeria

Abdu

Malami

2011

Ann Afr Med

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“…Tight cohesion and nuclear molding among the tumor cells are distinct cytologic features. There are limited studies on FNAC of retinoblastoma. Sen et al described FNAC of three cases of retinoblastoma.…”

Section: Malignant Neoplasm Of Eyelidmentioning

confidence: 99%

“…There are limited studies on FNAC of retinoblastoma. Sen et al described FNAC of three cases of retinoblastoma. FNAC diagnosis of retinoblastoma was made on the basis of both clinical and cytomorphological features.…”

Section: Malignant Neoplasm Of Eyelidmentioning

confidence: 99%

Fine‐needle aspiration cytology of orbital and eyelid lesions

Agrawal

Dey

Lal

2013

Diagnostic Cytopathology

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Fine-needle aspiration cytology (FNAC) of orbital lesions is now increasingly popular. Because of its unique location and the occurrence of varieties of lesions, diagnosis of orbital lesion is a challenge to the cytopathologists. FNAC of orbital and eyelid tumors is a suitable diagnostic technique that necessitates close co-operation between the ophthalmologist and pathologist. No radical procedure should be planned on the basis of FNAC, but it allows the diagnosis of a new primary lesion or the recurrence or metastasis of a tumor and can be done to identify lesions that require either specific medical therapy, as in nonresectable, inflammatory, and lymphoid tumors, or limited surgery for benign resectable neoplasms. With the help of various ancillary techniques a definitive diagnosis is possible on orbital and adnexal lesions. It is essential to have a detailed knowledge on the FNAC of these lesions and their potential pitfalls. In this present review, we have discussed various orbital lesions, their clinical presentations, cytomorphology, and ancillary techniques to confirm the diagnosis.

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“…If a Rb is suspected FNAB and vitrectomy are contraindicated. Nevertheles for some authors FNAB is considered a viable diagnostic choice in selected cases of leukocoria when conventional investigative modalities are inconclusive or when the patient of suspected Rb refuses enucleation [15]. If a case of Rb is punctured and confirmed by pathology, enucleation must be performed immediatly.…”

Section: Discussionmentioning

confidence: 99%