Diagnostic Imaging of Thoracic Aortic Atherosclerosis

Tunick, Paul A.; Krinsky, Glenn A.; Lee, Vivian S.; Kronzon, Itzhak

doi:10.2214/ajr.174.4.1741119

Cited by 34 publications

(15 citation statements)

References 57 publications

(56 reference statements)

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“…10 Imaging of the Aorta Transesophageal echocardiography (TEE), computed tomography (CT), and magnetic resonance imaging (MRI) are standard clinical imaging techniques for the visualization, characterization, and quantification of atherosclerotic plaque in the aorta. 11 At present, TEE is the most commonly used imaging technique for the detection and measurement of the aortic atherosclerotic plaque. 12,13 A correlation between in vivo findings of advance atherosclerotic plaque on TEE and embolization phenomena was first reported in 1990 by Tunick and Kronzon in 2 patients with neurological events and in 1 patient with both a stroke and an embolism to a toe.…”

Section: Atheromatous Plaque In a Proximal Arterymentioning

confidence: 99%

Cholesterol Embolization Syndrome

2010

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Section: Atheromatous Plaque In a Proximal Arterymentioning

confidence: 99%

Cholesterol Embolization Syndrome

2010

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“…46,47 Studies also have shown an association between aortic plaque seen on chest x-ray and the subsequent development of clinical CAD. 48 Examinations of the aorta by B-mode US 49 and TEE 50 have been used as predictors of CAD and cardiovascular risk. 14 Using TEE, the French Aortic Plaque in Stroke group 14,15 found a significantly increased risk of all vascular events for patients who had noncalcified aortic plaques Ͼ4 mm in thickness.…”

Section: Noninvasive Imagingmentioning

confidence: 99%

Clinical Imaging of the High-Risk or Vulnerable Atherosclerotic Plaque

Fayad

Fuster

2001

Circulation Research

455

293

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Abstract-The study of atherosclerotic disease during its natural history and after therapeutic intervention will enhance our understanding of disease progression and regression and aid in selecting appropriate treatments. Several invasive and noninvasive imaging techniques are available to assess atherosclerotic vessels. Most of the standard techniques identify luminal diameter, stenosis, wall thickness, and plaque volume; however, none can characterize plaque composition and therefore identify the high-risk plaques. We will present the different imaging modalities that have been used for the direct assessment of the carotid, aortic, and coronary atherosclerotic plaques. We will review in detail the use of high-resolution, multicontrast magnetic resonance for the noninvasive imaging of vulnerable plaques and the characterization of plaques in terms of their various components (ie, lipid, fibrous, calcium, or thrombus

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“…10 Similarly, aortic atheroma is associated with cerebrovascular events and peripheral vascular disease. [12][13][14][15][16][17] Aortic atherosclerosis may also produce localised complications from either thrombo-embolism or the development of adverse positive remodelling with aneurysm formation. been used to determine the presence of plaques within the aorta.…”

Section: Atheroma and Cardiovascular Diseasementioning

confidence: 99%

“…been used to determine the presence of plaques within the aorta. 2,12 Detailed ultrasound examination of the abdominal aorta can be performed in young adults and it is possible to measure the ratio of intimal to media thickness (IMT). [18][19][20] Aortic IMT increases with age at a greater rate that carotid IMT.…”

Section: Atheroma and Cardiovascular Diseasementioning

confidence: 99%

PET imaging of aortic atherosclerosis: Is combined imaging of plaque anatomy and function an amaranthine quest or conceivable reality?

Small

Ruddy

2011

Journal of Nuclear Cardiology

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Traditionally, blood vessels have been studied using contrast luminography to determine the site, extent and severity of luminal compromise by atherosclerotic deposits. Similar anatomical data can now be acquired non-invasively using ultrasound, computed tomography or magnetic resonance imaging. Plaque stability is an important determinant of subsequent vascular events and currently functional data on the stability of plaque is less well provided by these methods. The search for non-invasive techniques to image combined plaque anatomy and function has been pursued with visionary anticipation. This expectation may soon be realised as imaging with radionuclide-labelled atheroma-targeted contrast agents has demonstrated that plaque functional characteristics can now be shown. Increasingly positron emission tomography/computed tomography (PET/CT) imaging with (18)F fluorodexoyglucose (FDG) and other radionuclides is being used to determine culprit plaques in complex clinically scenarios. Clinically, this information may prove extremely valuable in the assessment of stable and unstable patients and its use in prime time medical practice is eagerly awaited. We will discuss the current clinical applications of functional atheroma imaging in the aorta and highlight the promising preclinical data on novel image biomarkers of plaque instability. If clinical science is able to successfully translate these advances in vascular imaging from the bench to the bedside, a new paradigm will be achieved in cardiovascular diagnostics.

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Diagnostic Imaging of Thoracic Aortic Atherosclerosis

Cited by 34 publications

References 57 publications

Cholesterol Embolization Syndrome

Cholesterol Embolization Syndrome

Clinical Imaging of the High-Risk or Vulnerable Atherosclerotic Plaque

PET imaging of aortic atherosclerosis: Is combined imaging of plaque anatomy and function an amaranthine quest or conceivable reality?

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