Diagnostic Features of Atopic Dermatitis

Hanifin, Jon M.; Rajka, G

doi:10.2340/00015555924447

Cited by 3,910 publications

(267 citation statements)

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“…Even though some controversies still remain over the plausible mechanisms and epidemiology of comorbid atopic disease in AD, 10 the presence of comorbidities like asthma, hay fever and food allergy are part of the diagnosis criteria for AD. 11 , 12 In a previous small Argentinean study with severe AD, prevalence of rhinitis and asthma were reported as higher; 13 however, our study included a larger sample with pediatric and adult patients, probably representing closely the real-world along the whole severity spectrum of AD patients population in the country.…”

Section: Discussionmentioning

confidence: 84%

Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Echeverría¹,

Angles

Larralde

et al. 2022

Rev Fac Cien Med Univ Nac Cordoba

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Background: Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin condition that is associated with detrimental effects on the lives of patients and their families, including an impact on quality of life (QOL). Studies about QOL on Latin American AD patients are scarce and have generally included few patients. Objective: describing AD impact on the QOL in a large cohort in Argentina. Methods: a structured web-based survey including 1,650 AD pediatric and adult patients was performed. Results: according to retrieved data, AD symptoms onset started during childhood in most patients, but 20 % of participants reported that manifestations of AD were initially perceived during late adolescence and adulthood. Important differences were observed among country regions, with a shorter time-to-diagnosis in most populated and richer districts. Main affected domains included frustration, anger, mood alterations, stress, sleep alterations, routine alterations, pain and economic impact of AD. Limitations: biases inherent to survey design. Conclusions: we consider that our study contributes to a better understanding of AD in Argentina, as well as its physical, social and financial impact on affected patients.

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Section: Discussionmentioning

confidence: 84%

Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Echeverría¹,

Angles

Larralde

et al. 2022

Rev Fac Cien Med Univ Nac Cordoba

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“…Additionally, 11 healthy individuals with negative patch test results were assigned to the control group (Table 1; non‐ACD group; n = 11; 3 males, 8 females; mean age = 41.18 ± 10.28 years old, range = 24–53 years old). No ACD or control group subject had a history of previous atopic dermatitis, according to the diagnostic criteria of Hanifin and Rajka 12 . Four cryopreserved skin samples, obtained from patients with severe atopic dermatitis (AD group; mean age = 28.5 ± 3.11; age range = 25–32 years old; mean EASI = 48.88 ± 8,82, EASI range = 38–57), were also selected as a control group with dermatitis.…”

Section: Methodsmentioning

confidence: 99%

Perivascular clusters of Th2 cells and M2 macrophages in allergic contact dermatitis to methylchloroisothiazolinone and methylisothiazolinone

Virgens

Goes

Carvalho

et al. 2021

Experimental Dermatology

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Background: Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) are among the most common skin sensitizers, yet the immunological events that occur during MCI/MI allergic contact dermatitis (ACD) are still poorly understood. Objectives: To analyse dendrocytes, macrophage subtypes and T cells in skin during the elicitation phase of MCI/MI ACD. Methods: Thirteen patients with positive patch test reactions to MCI/MI (ACD group) and 11 individuals with negative patch test results were selected. Skin biopsies were only performed at 48 hours of patch testing. Immunohistochemistry was conducted to assess T cells, dendrocytes (Factor XIIIa), M1 (p-Stat1, CD68) and M2 (c-Maf, CD163) macrophages. Transcriptional analyses were performed for cytokines and related factors, and further compared to atopic dermatitis samples (n=4). Immunofluorescence assays addressed T cells location, along with IL-4 or IL-13, within the skin. Results: MCI/MI elicited dermal dendrocytes and macrophages, pronouncedly the M2 subtype. T cells, majorly CD4+ T cells, accumulated in the perivascular areas. Similarly, abundant IL-4 protein was detected in these areas. There was an upregulation of IL-4 and IL-13 mRNA expression, a mild increase in IFNG mRNA levels and a down-regulation of RORC in the ACD group. Immunofluorescence revealed dermal clusters of T cells co-localized with IL-4. Conclusions: M2 macrophages and Th2 cells participate in the immunopathogenesis of MCI/MI ACD. Dermal dendrocytes and M2 macrophages may assist the formation of CD4+ T cells perivascular clusters. These findings render a mechanistic insight into the MCI/MI reaction. Further analysis at different timepoints of patch testing is required to fully comprehend this ACD kinetics.

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“…Seventy patients with AD were enrolled in the study. The diagnosis of AD was made according to the HanifinRajka criteria [8]. The age, gender, and history of personal or family history of allergic rhinitis or asthma were taken from the patients or their caregivers.…”

Section: Methodsmentioning

confidence: 99%

“…There are major and minor criteria for the diagnosis of AD that are established by Hanifin and Rajka [8]. The major criteria (must have 3 or more) include pruritus, typical mor-phology and distribution (flexural lichenification in adults, and facial and extensor involvement in infancy), Dermatitis (chronically or chronically relapsing), and Personal or family history of atopy-asthma, allergic rhinitis, and AD.…”

Section: Introductionmentioning

confidence: 99%

The Significance of Blood Eosinophilia in Atopic Dermatitis

.¹,

.²

2021

amj

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Background: Atopic dermatitis (AD) is chronic relapsing, pruritic, inflammatory skin disease. It usually accompanies other atopic problems like asthma and allergic rhinitis. Eosinophil plays a role in patients with AD. Objectives: To assess blood eosinophils in patients with AD and to evaluate the factors that are affecting the blood eosinophilia. Materials and methods: This prospective study was conducted at Hit General Hospital in the period from October 2018-October 2019. The age, gender, and personal or family history of asthma or allergic rhinitis of the patients with AD were recorded. The severity of the disease was assessed by the SCORAD score. The total number of eosinophil was measured for each subject. The data were analyzed using SPSS version 22. Results: Out of 70 patients with AD, 38 (54.3%) were females, and 32 (45.7%) males. The age of the patients ranged from 8 months to 30 years (mean 7.59±7.40). The highest age group affected was 2-12 years 40 (57.1%). The SCORAD score ranged from 6-80 (mean 24.19±17.59). The majority of our patients with mild course 50 (71.1%). The majority of the cases were without a history of asthma (n=53,75.7%), and around 50% without allergic rhinitis. The range of eosinophil count was 42-3360 (mean 636.44±491.37). The majority of the subjects (n=53,75.7%) with mild eosinophilia (500-1500/ mm 3 ). The age, gender, and patients with a history of allergic rhinitis or asthma had no significant effect on the number of eosinophils (P-Value >0.05). While, there was a high statistically significant difference between the eosinophils count, and the severity of AD (P-Value=0.000). Conclusion: From these findings we concluded that blood eosinophilia is a relatively common laboratory finding of AD. Blood eosinophilia was influenced by the severity of AD.

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Diagnostic Features of Atopic Dermatitis

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Cited by 3,910 publications

References 0 publications

Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Impact of atopic dermatitis on quality of life: a large web-based survey from Argentina

Perivascular clusters of Th2 cells and M2 macrophages in allergic contact dermatitis to methylchloroisothiazolinone and methylisothiazolinone

The Significance of Blood Eosinophilia in Atopic Dermatitis

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